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| 1 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 2 | Physiological Effect of Kinetin on the Photosynthetic Apparatus and Antioxidant Enzymes Activities During Production of Anthurium显示文摘The results observed in the literature raise the hypothesis according to which cytokinin plays important roles in photosynthetic metabolisms and antioxidant enzymes. Thus, the study aimed to evaluate the effect of foliar application of the isolated cytokinin kinetin at the production cycle, seeking to analyze its effects on enzyme activity and photosynthetic parameters. The plants treated with CK presented reduction of leaf CO_2 assimilation rate(Pn) and stomatal conductance(Gs), while that transpiration rate(Tr) was unaffected. The internal CO_2 concentrations decreased with the increase in cytokinin levels, but were maintained under CK 50 mg·L^(-1). The plants treated with CK 75 mg·L^(-1) was verified higher carboxylation efficiency(Pn/Ci), which was associated to values of CO_2 assimilation and transpiration unaltered. Apparent electron transport rate showed variations in the concentration of 25 mg·L^(-1). Considering the study of enzyme activity, on the other hand, it cannot be stated that kinetin has an effective action in delaying oxidative damage. It presents mixed results, since an efficiency in the application of cytokinin was not observed, presenting induction levels of ascorbate peroxidase activity. Thus, further research is needed to determine more precisely the effects of kinetin on gas exchange and antioxidant enzymes in anthurium plants. | de MOURA Fabiana B. VIEIRA Marcos R. da S. SIMOES Adriano do N. FERREIRA-SILVA Sérgio L. de SOUZA Carlos A.V. de SOUZA Eduardo S. da ROCHA Alexandre T. da SILVA Luzia F. JUNIOR Miguel A. | 2018 | Horticultural Plant Journal2018，4，5： | 3 |
| 3 | Thrombosis in ST-elevation myocardial infarction:Insights from thrombi retrieved by aspiration thrombectomy显示文摘In patients with ST-elevation myocardial infarction, recurrent cardiovascular events still remain the main cause of morbidity and mortality, despite significant improvements in antithrombotic therapy. We sought to review data regarding coronary thrombus analysis provided by studies using manual aspiration thrombectomy(AT), andto discuss how insights from this line of investigation could further improve management of acute coronary disease. Several studies investigated the fresh specimens retrieved by AT using techniques such as traditional morphological evaluation, optical microscopy, scanning electron microscopy, magnetic resonance imaging, and immunohistochemistry. These approaches have provided a better understanding of the composition and dynamics of the human coronary thrombosis process, as well as its relationship with some clinical outcomes. Recent data signaling to new antithrombotic therapeutic targets are still emerging. | Daniel Rios P Ribeiro Eduardo Cambruzzi Marcia Moura Schmidt Alexandre S Quadros | 2016 | World Journal of Cardiology2016，8，6： | 2 |
| 4 | Excentral cleavage of beta- carotene in vivo in a healthy man显示文摘 | HO C C de MOURA F F KIM S H | 2007 | Clin Nutr2007，85，3： | 1 |
| 5 | Discovering search engine related query using association rules显示文摘 | Fonseca B M Golgher P B Moura E S | | 0，，04： | 1 |
| 6 | Isolation of Nosema algerae from cornea of an immunnocompetent patient显示文摘 | Visvesvara G S Belloso M Moura H | 1999 | J Eukaryot Microbiol1999，46，5： | 1 |
| 7 | Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis显示文摘 | Moura LM Faria S Brito M | 2012 | Am J Cardiovasc Dis2012，2，： | 1 |
| 8 | Age- related changes in muscle fiber type frequencies and cross-sectional areas in straightbred and crossbred rabbits显示文摘 | BIANOSPINO E MOURA A S A M T WECHSLER F S | 2008 | Animal2008，2，11： | 1 |
| 9 | Energy metabolism in human pluripotent stem cells and their differentiated counterparts显示文摘 | Varum S Rodrigues AS Moura MB | | 0，，： | 1 |
| 10 | Influence of enamelsandblasting prior to etching on shear bond strength ofindirectly bonded lingual appliances 显示文摘 | Cal-NetoJP Castro S Moura PM | 2011 | Angle Orthod2011，81，1： | 1 |
| 11 | Kalman filtering with intermittent observations: weak convergence to a stationary distribution显示文摘 | Kar S Sinopoli B Moura J M F | 2012 | IEEE Transactions on Automatic Control2012，57，2： | 1 |
| 12 | Production of multiple plant hormones from a single poly protein precursor显示文摘 | Pearce G Moura D S Stratmann J | 2001 | Nature2001，411，6839： | 1 |
| 13 | QD-Leaming:a collaborative distributed strategy for multi-agent reinforcement learning through consensus plus innovations显示文摘 | KAR S MOURA J M F POOR H V | 2013 | IEEE Transactions on Signal Processing2013，61，7： | 1 |
| 14 | Supercritical fluid extraction from rosemary (Rosmarinus oficinalis):Kinetic data,extract s global yield,composition,and antioxidant activity显示文摘 | Carvalho R N Jr Moura L S Paulo T V Rosa | | 0，，： | 1 |
| 15 | Mitochon- drial dysfunction in neurodegenerative diseases and canc- er 显示文摘 | de Moura M B dos Santos L S Van Houten B | 2010 | Environ Mol Mutagen2010，51，5： | 1 |
| 16 | DILAND: An algorithm for distributed sensor localization with noisy distance measurements 显示文摘 | Khan UA Kar S Moura JMF | 2010 | IEEE Transactions on Signal Processing2010，58，3： | 1 |
| 17 | Prediction of low velocity impact damage in carbon-epoxy laminates显示文摘 | de Moura M F S F Marques A T | 2002 | Composites: Part A2002，331，： | 1 |
| 18 | Energy and water balance measurements for water productivity analysis in irrigated mango trees, Northeast Brazil显示文摘 | Teixeira A H C Bastiaanssen W G M Moura M S B | 2008 | Agricultural and Forest Meteorology2008，，148： | 1 |
| 19 | Tensile behaviour of three-dimensional carbon-ep- oxy adhesively-bonded single and double-strap repairs 显示文摘 | CAMPILHO R D S G MOURA D E M F S F RAMANTANI D A | 2009 | International Journal of Adhesion and Adhesives2009，29，6： | 1 |
| 20 | Nitrate and nitrite utilization in sulfate-reducing bacteria 显示文摘 | Moura I Bursakov S Costa C | 1997 | Anaerobe1997，3，5： | 1 |
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