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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Intracellular Pool of Vascular Endothelial Growth Factor in Human Neutrophils显示文摘 | Murielle G Olivier B Valérie A | 1997 | Blood1997，90，10： | 1 |
| 3 | Meta-DiSc: a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 4 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 5 | Meta-DiSc : a software for Meta- analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 6 | Meta-DiSc:a softwarefor meta-analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med ResMethodol2006，6，： | 1 |
| 7 | Real-time Fou- rier transformer based on fiber grating 显示文摘 | Muriel M A Azana J Carballar A | 1999 | Opt Lett1999，24，1： | 1 |
| 8 | Meta-Disc:a software for meta-analysis of test accuracy data 显示文摘 | Zarnora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，1： | 1 |
| 9 | Meta-DiSc: asoftware for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 10 | Meta-DiSc : a software for me- ta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 11 | Optimal ordering policies with convertible lead times 显示文摘 | Gallego G Jin Y Muriel A | 2007 | European Journal of Operational Research2007，176，2： | 1 |
| 12 | Security Issues in All-optical networks显示文摘 | DOUGLAS M RICHARD A | 1997 | IEEE Network Maga-zine1997，56，： | 1 |
| 13 | Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis显示文摘 | Namekawa M Muriel MP Janer A | 2007 | Mol Cell Neurosci2007，35，1： | 1 |
| 14 | Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis 显示文摘 | Wilhmina EM Muriel PC Grooteman A J | 2000 | Nephrol Dinal Transplant2000，15，3： | 1 |
| 15 | Meta-DiSc:a software formeta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 16 | Modelling the factors that influence fish guilds composition using a back-propagation network: Assessment of metrics for indices of biotic integrity 显示文摘 | Alonso A I Muriel G | 2003 | Ecological Modelling2003，160，： | 1 |
| 17 | An efficient inverse scattering algorithm for the design of nonuniform fiber Bragg gratings显示文摘 | Feced R Zervas M N Muriel M A | 1999 | IEEE J Quantum Electron1999，35，8： | 1 |
| 18 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，，6： | 1 |
| 19 | Meta-DiSc:a software for metaanalysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 20 | An efficient inverse scattering algorithm for the design of nonuniform fiber Bragg gratings显示文摘 | Feced R Zervas M N Muriel M A | 1999 | IEEE J Quantum Electron1999，35，8： | 1 |
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