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| 1 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 2 | Expression of glycodelin in human breast cancer:immunohistochemical analysis in mammary carcinoma in situ,invasive carcinomas and their lymph node metastases显示文摘 | Mylonas I Kunert-Keil C | 2005 | Anticancer Res2005，25，3： | 1 |
| 3 | Endocrine manipulation of spawning in cultured fish:from hormones to genes显示文摘 | Yonathan Zohr Constantions C Mylonas | 2001 | Aquaculture2001，197，： | 1 |
| 4 | Femoral and lower costosternal junctions′osteitis in an adult with SAPHO syndrome:an unusual presentation显示文摘 | Mylona E Golfinopoulou S Peppas C | 2008 | Joint Bone Spine2008，75，3： | 1 |
| 5 | Bombesin and neurotensin reduce endotoxemia intestinal oxidative stress and apoptosis in experimental obstructive jaundice显示文摘 | Assimakopoulos S F Scopa C D Zervoudakis G Mylonas P G Georgiou C Nikolopoulou V | 2005 | Ann Surg2005，241，： | 1 |
| 6 | Preparation and Evaluation of Polyanhydride Microspheres Containing Gonadotropin-Releasing Hermone(GnRH), for Inducing Ovulation and Spermiation in Fish显示文摘 | Mylonas C C Tabata Y Langer R | 1995 | J Control Release1995，35，： | 1 |
| 7 | Femoral and lower costostemal junctions osteitis in an adult with SAPHO syndrome: an unusual presentation 显示文摘 | Mylona E Golfinopoulou S Peppas C | 2008 | Joint Bone Spine2008，75，： | 1 |
| 8 | Species specificity in the magnitude and duration of the acute stress response in Mediterranean marine fish in culture显示文摘 | Fanouraki E Mylonas C C Papandroulakis N | 2011 | General and Comparative Endocrinology2011，173，2： | 1 |
| 9 | The clinicopathologicaland prognostic significance of membrane type-1 matrix metallopro-teinase(MT1-MMP)and MMP-9 according to their localization ininvasive breast carcinoma显示文摘 | Mylona E Nomikos A Magkou C | 2007 | Histopathology2007，50，3： | 1 |
| 10 | Analysis of the Sox gene family in the European sea bass(Dicentrarchus labrax)显示文摘 | Galay-Burgos M Llewellyn L Mylonas C C | | 0，，： | 1 |
| 11 | Analysis of the Sox gene family in the European sea bass(Dicentrarchus labrax)显示文摘 | Galay-Burgos M Llewellyn L Mylonas C C | 2004 | Comp Biochem Physiol B Biochem Mol Biol2004，137，2： | 1 |
| 12 | Com- parative efficacy of clove oil and 2 - phenoxyethanol as anesthet- ics in the aquaculture of European sea bass (Dicentrarchus la- brax) and gilthead sea bream( Sparus aurata)at different temper- atures 显示文摘 | MYLONAS C C CARDINALETYI G SIGELAKI l | 2005 | Aquaculture2005，246，14： | 1 |
| 13 | Hydrogen-bonding interaction of an alternating maleic acid-vinyl acetate eopolymer with po显示文摘 | Vasile C Bumbu G G Mylonas Y | 2003 | Polym Int2003，52，12： | 1 |
| 14 | Effects of humic acids and fulvic acids on growth of tobacco显示文摘 | Mylonas V A Mccants C B | 1980 | Plant and soil1980，，54： | 1 |
| 15 | Lipid peroxidation and tissure damage显示文摘 | Mylonas C Kouretas D | 1999 | In Vivo1999，13，： | 1 |
| 16 | Analysis of the Sox gene family in the European sea bass(Dicentrarchus labrax) 显示文摘 | Galay-Burgos M Llewellyn L Mylonas C C | 2004 | Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology2004，137，2： | 1 |
| 17 | Ktherosclerosis an inflammatory disease显示文摘 | Mylonas C | 1999 | N Engl J Med1999，340，2： | 1 |
| 18 | Expression of glycodelin A in decidual tissue of preeclamptic,HELLP and intrauterine growth-restricted pregnancies显示文摘 | Kunert-Keil C Mylonas I | 2005 | Virchows Arch2005，446，4： | 1 |
| 19 | Broodstock management and hormonal manipulations offish reproduction显示文摘 | Mylonas C Fostier A Zanuy S | 2010 | Gen Comp En- docrinol2010，165，： | 1 |
| 20 | Lipid peroxidation and tissue damage显示文摘 | Mylonas C Kouretas D | 1999 | In Vivo1999，13，3： | 1 |
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