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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Adsorption and dissolution behavior of human plasmafibronectinon thermallyand chemicallymodified titaniumdioxide particles显示文摘 | Mac DONALD D E DEO N MARKOVIC B | 2002 | Biomaterials2002，23，4： | 1 |
| 3 | Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury显示文摘 | Brody D L Mac Donald C Kessens C C | 2007 | Journal of neurotrauma2007，24，4： | 1 |
| 4 | The crystal chemistry of manganese-bearing elbaite显示文摘 | Burns P C Mac Donald D J Hawthorne F C | 1994 | Can Mineral1994，32，： | 1 |
| 5 | Development and evaluation of consensus-based sediment quality guidelines for freshwater ecosystems显示文摘 | Mac Donald D D Ingersoll C G Berger T A | 2000 | Archives of\sEnvironmental Contamination and Toxicology2000，39，1： | 1 |
| 6 | Spirituality and boredom proneness显示文摘 | Mac Donald D A Holland D | 2002 | Personality and Individual Differences2002，32，： | 1 |
| 7 | A preliminary evaluation of sediment quality assessment values for freshwater ecosystems显示文摘 | Smith S L Mac Donald D D Keenleyside K A | 1996 | J Great Lakes Res1996，22，3： | 1 |
| 8 | Development and evaluation of consensus-based sediment quality guidelines for freshwater ecosystems显示文摘 | Mac Donald D D Ingersoll C Berger T | 2000 | Arch Environ Contam Toxicol2000，39，1： | 1 |
| 9 | Adolescent risk behavior and the influence of parents and education显示文摘 | Nelson B V Patience T H Mac Donald D O | 1999 | Journal of the American Board of Family Medicine1999，12，： | 1 |
| 10 | Finite element simulation of stent and balloon interaction显示文摘 | Chua S N D Mac Donald B J Hashmi M S J | 2003 | J Mater Process Technol2003，，143144： | 1 |
| 11 | Effects of varying slotted tube (stent)geometry on its expansion behavior using finite element method 显示文摘 | Chua S N D Mac Donald B J Hashmi M S J | 2004 | J Mater Process Technol2004，，155156： | 1 |
| 12 | Finite element simulation of slotted tube (stent)with the presence of plaque and artery by balloon expansion显示文摘 | Chua S N D Mac Donald B J I-Iashmi M S J | 2004 | J Mater Process Technol2004，，155156： | 1 |
| 13 | Finite-element simulation of stent expansion显示文摘 | Chua S N D Mac Donald B J Hashmi M S J | 2002 | J Mater Process Technol2002，120，： | 1 |
| 14 | Evaluation of the psychometric properties of the phlebitis and infiltration scales for the assessment of complications of peripheral vascular access devices显示文摘 | Groll D Davies B Mac Donald J | 2010 | J IMus Nuts2010，33，6： | 1 |
| 15 | Incidence of adverse biological effects within ranges of chemical content ration sinmarine and estuarine sediments 显示文摘 | Long E R Mac Donald D D Smith S L | 1995 | Environ Manag1995，19，1： | 1 |
| 16 | Proprioception in anterior cruciate ligament-deficient and reconstructed knees显示文摘 | Mac Donald PB Hedden D Pacin O | 1996 | Am J Sports Med1996，24，6： | 1 |
| 17 | Simultaneous determination of aflatoxins and ochratoxin A in food using a fully automated immunoaffinity column clean-up and liquid chromatography-fluorescence detection显示文摘 | Chan D Mac Donald S J Boughtflower V | 2004 | Journal of Chromatography A2004，1059，： | 1 |
| 18 | Predicting toxicity in marine sediments with numerical sediment quality guidelines 显示文摘 | Long E R Field L J Mac Donald D D | 1998 | Environmental Toxicology and Chemistry1998，17，4： | 1 |
| 19 | Evaluation of the psychometric properties of the phlebitis and infiltration scales for the assessment of complications of peripheral vascular access devices显示文摘 | Groll D Davies B Mac Donald J | 2010 | J Infus Nuts2010，33，6： | 1 |
| 20 | Simultaneou determination of aflatoxins and ochratoxin A in food using a fully automated immunoaffinity column clean-up and liquid chromatography-fluorescence detection显示文摘 | Chan D Mac Donald S J Boughtflower V | 2004 | J Chromatogr A2004，1059，12： | 1 |
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