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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | identification of the 72- kDa(MMP - 2)and 92 - kDa(MMP - 9)gelatinase type iv collar - genase in preparations of laminin and Matrigel 显示文摘 | Mackay A R Gomez D E Cottam D W | 1993 | Biotech - niques1993，15，： | 1 |
| 3 | Impacts of input parameter spa-tial aggregation on an agricultural nonpoint source pollutionmodel显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of Hydrology2000，236，： | 1 |
| 4 | Impacts of input parameter spatial aggregation on agricultural non-point source pollution model显示文摘 | FITZHUGH T W MACKAY D S | 2000 | Journal of Hydrology2000，236，： | 1 |
| 5 | Impacts of input parameter spatial aggregation on an agricultural non-point source pollution model显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of Hydrology2000，236，12： | 1 |
| 6 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 7 | Uptake of organic chemicals by plants:A review of processes,correlations and models显示文摘 | Paterson S Mackay D Tam D Shiu W Y | 1990 | Chemosphere1990，21，3： | 1 |
| 8 | A critical review of aqueous solubilities, vapor pressures, Henry's Law constants and octano-water partition coefficients of the polychlorinated biphenyls 显示文摘 | Shiu W Y Mackay D 1986 | 1986 | Journal of Physics and Chemistry Reference Data1986，15，： | 1 |
| 9 | Rate of Evaporation of Low - Solubility Contami- nants from Water Bodis to Atmosphere 显示文摘 | Mackay D Wolkoff A W | 1973 | Environment Science and Technol- ogy1973，，： | 1 |
| 10 | Detection of human respiratory syncytial virus in respiratory samples by LightCycler reverse transcriptase PCR显示文摘 | Whiley D M Syrmis M W Mackay I M | 2002 | J Clin Microbiol2002，40，12： | 1 |
| 11 | Evaporation rate of spills of hydrocarbons and petroleum mixtures显示文摘 | Mackay D | 1984 | Environment science and technology1984，18，： | 1 |
| 12 | Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7显示文摘 | PE Hesterberg D Winsor-Hines MJ Briskin D Soler-Ferran C Merrill CR Mackay W Newman DJ Ringler | 1996 | Gastroenterology1996，，： | 1 |
| 13 | Impact of marine fish farming on water quality and bottom sediment:a case study of the sub-tropical environment显示文摘 | WU R S LAM K S MACKAY D W et a1 | 1994 | Marine Environmental Research1994，38，2： | 1 |
| 14 | Generic models for evaluating the regional fate of chemical显示文摘 | Mackay D Paterson S Shiu W Y | 1992 | Chemosphere1992，24，6： | 1 |
| 15 | Evaporation Rate of Spills of Hydrocarbons and Petroleum Mextures 显示文摘 | Stiver W Mackay D | 1984 | Environ Sci Teeh1984，18，11： | 1 |
| 16 | Impacts of input parameter spatial aggregation on agricultural non-point source pollution model 显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of hydrology2000，，236： | 1 |
| 17 | Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides 显示文摘 | BULTE J W KRAITCHMAN D L MACKAY A M | 2004 | Blood2004，104，10： | 1 |
| 18 | Evaporation rate of spills of hydrocarbons and petroleum mixtures显示文摘 | Stiver W Mackay D | 1984 | Environmental Science & Technology1984，18，11： | 1 |
| 19 | Critical review of Henry's Law constants for pesticides 显示文摘 | Suntio L R Shiu W Y Mackay D | 1988 | Reviews of Environmental Contamination and Toxicology1988，103，： | 1 |
| 20 | Biologically mediated transport of contaminants to aquatic systems显示文摘 | BLAIS J M MACDONALD R W MACKAY D | 2007 | Environmental Science & Technology2007，41，4： | 1 |
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