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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Advanced oxidation processes for organic contaminant destruction based on the Fenton reaction and related chemistry 显示文摘 | PIGNATELLO J J OLIVEROS E MACKAY A | 2006 | Crit Rev Environ Sci Technol2006，36，1： | 1 |
| 3 | Environmentally responsive pep- tides as anticancer drug carriers显示文摘 | Aluri S Janib S M Mackay J A | 2009 | Adv Drug Deliv Rev2009，61，11： | 1 |
| 4 | Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant non-structural proteins in ELISA显示文摘 | Mackay D K J Forsyth M A Davies P R | 1997 | Vaccine1997，16，5： | 1 |
| 5 | An imprinted locus associated with transient neonatal diabetes mellitus 显示文摘 | Gardner RJ Mackay DJ Mungall A J | 2000 | Hum Mol Genet2000，9，4： | 1 |
| 6 | Women and tobacco显示文摘 | Mackay J Amos A | | 0，，02： | 1 |
| 7 | Acute COPD exacerba tions显示文摘 | Wedzicha J A Singh R Mackay A J | 2014 | Clin Chest Med2014，35，1： | 1 |
| 8 | Stability of discrete breathers显示文摘 | MACKAY R S SEPULCHRE J A | 1998 | Phys D1998，119，： | 1 |
| 9 | Segregating random amplified polymorphic DNAs(RAPDs)in Betula alleghaniensis 显示文摘 | Roy A Frascaria N Mackay J | 1992 | Theor Appl Genet1992，85，： | 1 |
| 10 | Sorption of ciprofloxacin and oxytetracycline zwitterions to soils and soil minerals: influence of compound structure 显示文摘 | Carrasquillo A J Bruland G L MacKay A A | 2008 | Environmental Science and Technology2008，42，20： | 1 |
| 11 | Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer:a systematic review and practice guideline显示文摘 | Noble J Ellis P M Mackay J A Evans W K | 2006 | J Thorac Oncol2006，1，： | 1 |
| 12 | Isolation of pleuropneumonia-like organisms (Genus Mycoplasma) from cases of sheep pulmonary adenomatosis 显示文摘 | Mackay J M K Nisber D I Foggie A | 1963 | Vet Rec1963，75，21： | 1 |
| 13 | An imprinted locus associated with transient neonatal diabetes mellitus 显示文摘 | Gardner RJ Mackay DJ Mungall A J | 2000 | Hum Mol Genet2000，9，4： | 1 |
| 14 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 15 | Olfactory ensheathing ceils promote locomotor recovery after delayed transplantation into transected spinal cord 显示文摘 | Lu J Feron F Mackay Sim A | 2002 | Brain2002，125，1： | 1 |
| 16 | Localized oscillations in eonsevative or dissipative networks of weakly coupled autonomous oscillators显示文摘 | SEPULCHRE J A MACKAY R S | 1997 | Nonlinearity1997，10，： | 1 |
| 17 | COPD exacerbations:causes,prevention,and treatment显示文摘 | Mackay A Hurst J | 2012 | The Medical Clinics Of North America2012，96，4： | 1 |
| 18 | Complete amino acid sequence of five dimeric and four monomeric forms of metallothionein from the edible mussel Mytilus edulis显示文摘 | Mackay E A Overnell J L Dunbar B | 1993 | European Journal of Biochemistry1993，218，： | 1 |
| 19 | Closure phase in highresolution optical imaging 显示文摘 | J E Baldwin C A Haniff C D Mackay | 1986 | Nature1986，320，： | 1 |
| 20 | Real-time PCR in virology显示文摘 | MACKAY I M ARDEN K J NITSCHE A | 2002 | Nucleic Acids Research2002，30，6： | 1 |
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