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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | APEX feedlot water quality simulation显示文摘 | Williams J R Harman W L Magre M | 2006 | Transactions of the ASABE2006，49，1： | 1 |
| 3 | Experimental study of a methane diffusion flame under dielectric barrier discharge assistance 显示文摘 | Randonnier A V Larigaldie S Magre P | 2007 | IEEE Trans on Plasmas Science2007，35，2： | 1 |
| 4 | Sex-specific expression of SOX9during gonadogenesis in the am-phibian Xenopus tropicalis显示文摘 | EI Jamil A Kanhoush R Magre S | 2008 | Dev Dyn2008，237，10： | 1 |
| 5 | Host range and interference studies of three classes of pig endogenous retrovirus 显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，： | 1 |
| 6 | The crystal structure of poly-p-phenylene sulfide 显示文摘 | Tabor B J Magre E P Boon J | 1968 | European Polymer Journal1968，，7： | 1 |
| 7 | Purified bovine AMH induces a characteristic freemartin effect in fetal rat prospective ovaries exposed to it in vitro显示文摘 | Vigier B Watrin F Magre S | 1987 | Development1987，100，： | 1 |
| 8 | Expression of AMH,SF1,and SOX9 in gonads of genetic female chickens during sex reversal induced by an aromatase inhibitor显示文摘 | Vaillant S V Magre S Dorizzi M | 2001 | Development Dynamics2001，222，： | 1 |
| 9 | Primary lipodystrophies 显示文摘 | Capeau J Magre J Lascols O | 2007 | Ann Endocrinol(Paris)2007，68，1： | 1 |
| 10 | Host range and interference studies of three classes of pig endogenous retrovirus显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，99： | 1 |
| 11 | Maternal and foetal corticosterone levels during late pregnancy in rat显示文摘 | Dupouy J P Coffingy H Magre S | 1975 | Endocrinology1975，65，： | 1 |
| 12 | Host range end interference studies of three classes of pig endogenous retrovius显示文摘 | Takeuchi Y Patience C Magre S | 1998 | Virol1998，72，12： | 1 |
| 13 | Host range and inter?ference studies of three classes of pig endogenous retrovirus显示文摘 | Takeuchi Y Patience C Magre S | 1998 | J Virol1998，72，12： | 1 |
| 14 | The crystal structure of poly-p-phenylene sulphide 显示文摘 | Tabor BJ Magre EP Boon J | 1971 | European Polymer Journal1971，7，8： | 1 |
| 15 | Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13显示文摘 | Magre J Delepine M Khallouf E | 2001 | Nat Genet2001，28，4： | 1 |
| 16 | Human lipodystrophies: genetic and acquired diseases of adipose tissue 显示文摘 | Capeau J Magre J Caron-Debarle M | 2010 | Endocr Dev2010，19，： | 1 |
| 17 | Use of different artificial neural networks to resolve binary blends of monocultivar Italian olive oils显示文摘 | Federico Marini Antonio L. Magrì Remo Bucci Andrea D. Magrì | 2007 | Analytica Chimica Acta2007，，2： | 1 |
| 18 | Human hormone-sensitive lipase genetic mapping,identification of a new dinucleotide repeat,and association with obesity and NIDDM显示文摘 | Magre J Laurell H Fizames C | 1998 | Diabetes1998，47，2： | 1 |
| 19 | Modelling and Analysis of Fraction Brownian Motions显示文摘 | O Magre M Guglielmi | 1997 | Choas Solitons & Fractals1997，8，3： | 1 |
| 20 | Early sta ges of testicular differentiation in the rat显示文摘 | JOST A MAGRE S AGELOPOULOU R | 1981 | Hum Genet1981，58，1： | 1 |
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