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| 1 | 台式液相色谱静电场轨道阱质谱联用系统显示文摘本文概述了基于具有卓越性能的Thermo Scientific Orbitrap静电场轨道阱质谱仪的新型Exactive台式质谱仪,对其主要的特性包括仪器设计、分析参数及应用进行了介绍。 | Andreas Wieghaus Alexander Makarov Ulf Froehlich Markus Kellmann Eduard Denisov Oliver Lange | 2011 | 分析测试学报2011，30，5： | 3 |
| 2 | Effect of fluence and ambient environment on the surface and structural modification of femtosecond laser irradiated Ti显示文摘Under certain conditions, ultrafast pulsed laser interaction with matter leads to the formation of self-organized conical as well as periodic surface structures(commonly reffered to as, laser induced periodic surface structures, LIPSS). The purpose of the present investigations is to explore the effect of fsec laser fluence and ambient environments(Vacuum &O_2) on the formation of LIPSS and conical structures on the Ti surface. The surface morphology was investigated by scanning electron microscope(SEM). The ablation threshold with single and multiple(N = 100) shots and the existence of an incubation effect was demonstrated by SEM investigations for both the vacuum and the O_2 environment. The phase analysis and chemical composition of the exposed targets were performed by x-ray diffraction(XRD) and energy dispersive x-ray spectroscopy(EDS), respectively. SEM investigations reveal the formation of LIPSS(nano & micro). FFT d-spacing calculations illustrate the dependence of periodicity on the fluence and ambient environment. The periodicity of nano-scale LIPSS is higher in the case of irradiation under vacuum conditions as compared to O_2. Furthermore, the O2 environment reduces the ablation threshold. XRD data reveal that for the O_2 environment, new phases(oxides of Ti) are formed. EDS analysis exhibits that after irradiation under vacuum conditions, the percentage of impurity element(Al) is reduced. The irradiation in the O_2 environment results in 15% atomic diffusion of oxygen. | Umm-i-Kalsoom Shazia Bashir Nisar Ali M Shahid Rafique Wolfgang Husinsky Chandra S R Nathala Sergey V Makarov Narjis Begum | 2016 | Chinese Physics B2016，25，1： | 2 |
| 3 | Multipotent stromal cells stimulate liver regeneration by influencing the macrophage polarization in rat显示文摘AIM To investigate the influence of the umbilical cordderived multipotent stromal cells(MSCs) on recovery of the liver after the subtotal resection, that is, removal of 80% of the organ mass, a renowned model of the small-for-size liver remnant syndrome. METHODS The MSCs were obtained from the intervascular tissue of umbilical cords, dissected from rat fetuses, by the explant culture technique. The vital labeling of MSCs with РКН26 was carried out on the 3 rd passage. The subtotal resection was performed on male Sprague-Dawley rats. The experimental group animals received a transplant 106 MSCs infused into the spleen. Hepatocyte proliferation was assessed by counting of either mitotic figures or Ki67-positive cells in microscopic images. MSC differentiation was assessed with antibodies to hepatocyte-specific marker cytokeratin 18(CK18), cholangiocyte-specific protein CK19, smooth muscle cell-specific protein α-SMA, the endothelial cell marker CD31, or the active fibroblast marker FAPα. Total macrophages of the liver were selectively stained in cryosections incubated with antiCD68 antibodies(1:100, Abcam), while the M2 a and M2 c macrophage populations were selectively stained with anti-CD206 antibodies. Expression of interleukin and growth factor genes was evaluated with PCR-RT.RESULTS Intrasplenic allogeneic transplantation of the umbilical cord-derived multipotent stromal cells stimulates reparative processes within the residual liver tissue after subtotal resection(removal of 80% of the organ mass), as indicated by increased rates of hepatocyte proliferation and accelerated organ mass recovery. These effects may result from paracrine influence of the transplanted cells on the resident macrophage population of the liver. The transplantation favors polarization of macrophages to M2 phenotype(the M2-polarized macrophages specifically express CD206; they are known to suppress inflammation and support tissue repair). No differentiation of the transplanted cells into any of the liver cell types have been observed in the study.CONCLUSION We found no direct evidence for the paracrine effect of MSCs on liver regeneration after the subtotal liver resection in rats. However, the paracrine mechanism of the therapeutic activity of transplanted MSC is indirectly indicated by a decrease in the total number of CD68 + macrophages and an increase in the proportion of M2 pro-repair macrophages in the regenerating liver as compared to animals in which the transplantation was only mimicked. | Andrey Elchaninov Timur Fatkhudinov Natalia Usman Irina Arutyunyan Andrey Makarov Anastasia Lokhonina Irina Eremina Viktor Surovtsev Dmitry Goldshtein Galina Bolshakova Valeria Glinkina Gennady Sukhikh | 2018 | World Journal of Hepatology2018，10，2： | 2 |
| 4 | Regenerative medicine of pancreatic islets显示文摘The pancreas became one of the first objects of regenerative medicine,since other possibilities of dealing with the pancreatic endocrine insufficiency were clearly exhausted.The number of people living with diabetes mellitus is currently approaching half a billion,hence the crucial relevance of new methods to stimulate regeneration of the insulin-secretingβ-cells of the islets of Langerhans.Natural restrictions on the islet regeneration are very tight;nevertheless,the islets are capable of physiological regeneration viaβ-cell self-replication,direct differentiation of multipotent progenitor cells and spontaneousα-toβ-orδ-toβ-cell conversion(trans-differentiation).The existing preclinical models ofβ-cell dysfunction or ablation(induced surgically,chemically or genetically)have significantly expanded our understanding of reparative regeneration of the islets and possible ways of its stimulation.The ultimate goal,sufficient level of functional activity ofβ-cells or their substitutes can be achieved by two prospective broad strategies:β-cell replacement andβ-cell regeneration.The“regeneration”strategy aims to maintain a preserved population ofβ-cells through in situ exposure to biologically active substances that improveβ-cell survival,replication and insulin secretion,or to evoke the intrinsic adaptive mechanisms triggering the spontaneous non-β-toβ-cell conversion.The“replacement”strategy implies transplantation ofβ-cells(as non-disintegrated pancreatic material or isolated donor islets)orβ-like cells obtained ex vivo from progenitors or mature somatic cells(for example,hepatocytes orα-cells)under the action of small-molecule inducers or by genetic modification.We believe that the huge volume of experimental and clinical studies will finally allow a safe and effective solution to a seemingly simple goal-restoration of the functionally activeβ-cells,the innermost hope of millions of people globally. | Irina V Arutyunyan Timur Kh Fatkhudinov Andrey V Makarov Andrey V Elchaninov Gennady T Sukhikh | 2020 | World Journal of Gastroenterology2020，26，22： | 2 |
| 5 | NF-κB in rheumatoid arthritis:a pivotal regulator of inflammation,hyperplasia,and tissue destruction显示文摘 | Sergei S Makarov SS | 2001 | Arthritis Res2001，3，： | 1 |
| 6 | Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005显示文摘 | Makarov DV Trock BJ Humphreys-EB | 2007 | Urology2007，69，6： | 1 |
| 7 | The ACMSDgene, involved in tryptophan metabolism, is mutated in a familywith cortical myoclonus, epilepsy,and parkinsonism显示文摘 | Martl-Mass6 JF Bergareche A Makarov V | 2013 | J MolMed (Beri)2013，91，12： | 1 |
| 8 | Effect of cavitation melt treatment on the structure refinement and property improvement in cast and deformed hypereutectic A1-Si alloys显示文摘 | ESKIN G I MAKAROV G S | 1997 | Materials Science Forum1997，242，： | 1 |
| 9 | JAm Chem Soc 显示文摘 | Hanan Sertchoom Hila Elimelech Carina Makarov | 2007 | 129(1): 98-1082007，129，1： | 1 |
| 10 | Effect of ultrasonic processing of molten metal on structure formation and im- provement of properities of high-strength A1-Zn-Mg-Cu-Zr alloys 显示文摘 | ESKIN G I MAKAROV G S PIMENOV Y U P | 1995 | Advanced Performance Materials1995，，2： | 1 |
| 11 | ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells显示文摘 | Smirnova E Goldberg E B Makarovs K S | 2006 | EMBO Rep2006，7，1： | 1 |
| 12 | NF - KappaB in rheumatoid arthritis a pivotal regulator of inflammation, hyperplasia, and tissue destruction 显示文摘 | Makarov SS | 2001 | Arthritis Res2001，3，4： | 1 |
| 13 | Cobalt behavior during natural and technogenic oxidative leaching of Co-containing pyrites ( Letnee chalcopyrite deposit, Southern Urals ) 显示文摘 | Gaskova 0 L Belogub E V Makarov D V | 2010 | Russian Geolo- gy and Geophysics2010，51，2： | 1 |
| 14 | The area centra|is o{ the mammalian retina: morphology and histogenesis 显示文摘 | Panikian K K Makarov F N Chumasov E I | 2008 | Morfologiia2008，134，6： | 1 |
| 15 | Blackout prevention in the United States,Europe,and Russia显示文摘 | MAKAROV Y V RESHETOV V I STROEV A | 2005 | Proceedings of the IEEE2005，93，11： | 1 |
| 16 | Updated nomogram to predict pathologic stage of prostate cancer given PSA, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000-2005显示文摘 | MAKAROV DV TROCK BJ HUMPHREYS EB | 2007 | Urology2007，69，6： | 1 |
| 17 | Simulation of heat transfer and melt flow in Czochralski growth of SiGe crystals显示文摘 | SMIRNOVA O V KALAEV V V MAKAROV Y N | 2004 | J Crystal Growth2004，，266： | 1 |
| 18 | Effects of external fixation and limb lengthening on peripheral nerve function显示文摘 | Makarov MR Birch JG Delgado MR | 1996 | Clin Orthop1996，329，4： | 1 |
| 19 | NF-KappaB is a Target of AKT in Anti-Apoptotic PDGF Signalling显示文摘 | ROMASHKOVA J A MAKAROV S S | 1999 | Nature1999，401，6748： | 1 |
| 20 | Numerical investigation of crucible rotation effect on crystallization rate behavior during Czochralski growth of SiGe crystals显示文摘 | SMIRNOVA O V KALAEV V V MAKAROV Y N | 2006 | J Crystal Growth2006，，287： | 1 |
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