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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 3 | Design, implementation and simulation analysis of a single-wellchemical tracer test to measure the residual oil saturation tohydroearbonmiscible gas atprudhoe bay 显示文摘 | Cockin A P Malcolm L T McGuire P L | 1998 | SPE 489511998，，： | 1 |
| 4 | Chlorination of humicmaterials: byproduct formation and chemical interpretations 显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science and Technology1990，24，： | 1 |
| 5 | Chlorination of humic materials: Byproduct formation and chemical interpretations显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science & Technology1990，24，11： | 1 |
| 6 | Chlorination of Humic Materials:Byproduct Formation and Chemical Interpretations显示文摘 | RECKHOW D A SINGER P C MALCOLM R L | 1990 | Environ Sci Technol1990，24，： | 1 |
| 7 | Risk factors for stress fractures in female tracd-and-field athletes: a retrospective analysis显示文摘 | BENNELL K L MALCOLM S A THOMAS S A | 1991 | Clin J Sport Med1991，5，： | 1 |
| 8 | Nursing Specialization in New South Wales,Australia显示文摘 | Appel A L Malcolm P A | 1996 | Clinical Nurse Specialist1996，10，2： | 1 |
| 9 | Ablation of tissue vol-umes using high intensity focused ultrasounc显示文摘 | MALCOLM A L TER HAAR G R | 1996 | UltrasoundMed Biol1996，22，5： | 1 |
| 10 | Fluoronated ethers显示文摘 | Albert L Henne Malcolm A Smook | 1950 | J Chem Soc1950，72，： | 1 |
| 11 | Electronic and redox properties of stacked-ring silicon phthalocyanines from molecular orbital theory显示文摘 | Alfred B A Terese L G Malcolm E K | 1985 | J Am Chem Soc1985，107，： | 1 |
| 12 | The structure of the exocellular polysaccharide produced by rhodococcus sp 显示文摘 | Malcolm B Perry Leann L MacLean a Marianna A Patrauchanb | 2007 | Carbohydrate Research2007，342，： | 1 |
| 13 | Genetic differen- tiation between and within strains of the saw - toothed grain beetle, Oryzaephilus surinamensisat RAPD loci显示文摘 | Brown R J Malcolm C A Mason P L | 1997 | Insect Bi- ology1997，6，3： | 1 |
| 14 | Chlorination of humic materials-byproduct formation and chemical interpretations 显示文摘 | RECKHOW D A SINGER P C MALCOLM R L | 1997 | Environ Sci Technol1997，24，7： | 1 |
| 15 | Pectins : structure, biosynthesis, and ligogalacturonide-related signaling 显示文摘 | Brent L Ridley Malcolm A O' Neill Debra Mohnen | 2001 | Phytochemistry2001，57，： | 1 |
| 16 | Chlorination of humic materials:byproduct formation and chemical inter- pretations 显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environ Sci Technol1990，24，1： | 1 |
| 17 | Analysis of a single-well chemical tracer test to measure the residual oil saturation to a hydrocarbon miscible gasflood at Prudhoe Bay 显示文摘 | Ccockin A P Malcolm L T McGuire P L | 2000 | SPE Reservoir Evaluation g Engineering2000，3，6： | 1 |
| 18 | Chlorination of humic materials: by products formation and chemical interpretations显示文摘 | David A Reckhow PhiliP C Singer Ronald L Malcolm | 1990 | Environmental Science and Technology1990，24，11： | 1 |
| 19 | Chlorination of humic materials:byproduct formation and chemical interpretations显示文摘 | Singer P C Malcolm R L | 1990 | Environ Sci Technol1990，24，11： | 1 |
| 20 | Scotopicelectroretinogram in term infants bom of mothers supplemented withdocosahexaenoic acid during pregnancy 显示文摘 | Malcolm C A Hamilton R Mcculloch D L | 2003 | Invest Ophthalmol VisSci2003，44，： | 1 |
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