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| 1 | Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease显示文摘The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease(NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically-oriented therapies(e.g., antioxidants, oral hypoglycemic agents, and lipid-lowering agents) often fail due to poor compliance and/or lack of efficacy, novel approaches directed toward other pathomechanisms are needed. Here we present several lines of evidence indicating that, by increasing energy extraction in some dysbiosis conditions or small intestinal bacterial overgrowth,specific gut microbiota and/or a'low bacterial richness'may play a role in obesity,metabolic syndrome,and fatty liver.Under conditions involving a damaged intestinal barrier('leaky gut'),the gut-liver axis may enhance the natural interactions between intestinal bacteria/bacterial products and hepatic receptors(e.g.,toll-like receptors),thus promoting the following cascade of events:oxidative stress,insulinresistance,hepatic inflammation,and fibrosis.We also discuss the possible modulation of gut microbiota by probiotics,as attempted in NAFLD animal model studies and in several pilot pediatric and adult human studies.Globally,this approach appears to be a promising and innovative add-on therapeutic tool for NAFLD in the context of multi-target therapy. | Giulia Paolella Claudia Mandato Luca Pierri Marco Poeta Martina Di Stasi Pietro Vajro | 2014 | World Journal of Gastroenterology2014，20，42： | 55 |
| 2 | Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions显示文摘Non-alcoholic fatty liver disease(NAFLD) in children is becoming a major health concern. A 'multiple-hit' pathogenetic model has been suggested to explain the progressive liver damage that occurs among children with NAFLD. In addition to the accumulation of fat in the liver, insulin resistance(IR) and oxidative stress due to genetic/epigenetic background, unfavorable lifestyles, gut microbiota and gut-liver axis dysfunction, and perturbations of trace element homeostasis have been shown to be critical for disease progression and the development of more severe inflammatory and fibrotic stages [non-alcoholic steatohepatitis(NASH)]. Simple clinical and laboratory parameters, such as age, history, anthropometrical data(BMI and waist circumference percentiles), blood pressure, surrogate clinical markers of IR(acanthosis nigricans), abdominal ultrasounds, and serum transaminases, lipids and glucose/insulin profiles, allow a clinician to identify children with obesity and obesity-related conditions, including NAFLD and cardiovascular and metabolic risks. A liver biopsy(the 'imperfect' gold standard) is required for a definitive NAFLD/NASH diagnosis, particularly to exclude other treatable conditions or when advanced liver disease is expected on clinical and laboratory grounds and preferably prior to any controlled trial of pharmacological/surgical treatments. However, a biopsy clearly cannot represent a screening procedure. Advancements in diagnostic serum and imaging tools, especially for the non-invasive differentiation between NAFLD and NASH, have shown promising results, e.g., magnetic resonance elastography. Weight loss and physical activity should be the first option of intervention.Effective pharmacological treatments are still under development; however, drugs targeting IR, oxidative stress, proinflammatory pathways, dyslipidemia, gut microbiota and gut liver axis dysfunction are an option for patients who are unable to comply with the recommended lifestyle changes. When morbid obesity prevails, bariatric surgery should be considered. | Maria Grazia Clemente Claudia Mandato Marco Poeta Pietro Vajro | 2016 | World Journal of Gastroenterology2016，22，36： | 32 |
| 3 | Vitamin E Treatment in Pediatric Obesity-Related Liver Disease: A Randomized Study显示文摘 | Pietro Vajro Claudia Mandato Adriana Franzese Edmondo Ciccimarra Stefania Lucariello Marcella Savoia Grazia Capuano Fiorella Migliaro | 2004 | Journal of Pediatric Gastroenterology and Nutrition2004，，1： | 2 |
| 4 | The gut-liver axis as a target of liver disease management显示文摘The interplay between the gut and liver,the so called“gut-liver axis”(GLA),plays a significant role in health and disease.As shown in Figure 1,the GLA is regulated by a number of equally relevant interacting factors including gut microbiota,integrity and function of the intestinal wall,antigen trafficking,mucosal innate immune response,and oxidative stress(1,2).In addition to undigested or unabsorbed food and microorganisms,the gut lumen contains also their fermentation/metabolic products,bile,mucus,and epithelial cells spontaneously exfoliated from the gastrointestinal mucosa.The latter is composed of various cell types counting immune cells,goblet cells,and enterocytes strongly connected by tight junctions and covered with a mucus layer that acts as a dynamic barrier.Recent elucidation of a gut-vascular barrier(GVB)has revealed this structure to intervene to control gut bacteria and antigen translocation from the gut into the blood stream(3).Interestingly,diseases that are characterized or aggravated by impairment of the barrier function(so-called“leaky gut”)and/or particular patterns of the microbiome(e.g.,a lack of balance between Bacteroides and Firmicutes)are not restricted to the intestinal tract and liver.Some relevant examples are represented by diabetes type 1,familial Mediterranean fever,obesity,cardiovascular disease,decreased bone-mass density,autism,dysregulation of immune response and systemic allergic diseases(1). | Claudia Mandato Anna Pia Delli Bovi Pietro Vajro | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 5 | Intestinal occlusion caused by malignant neoplasia of the colon: surgical strategy显示文摘 | Corsale I Foglia E Mandato M | 2003 | G Chir2003，24，3： | 1 |
| 6 | Small cell neuro - endocrinecervical carcinoma with I - year follow - up : case report and review显示文摘 | BIFULCO G MANDATO V D GIAMPAOLINO P | 2009 | Anticancer Research2009，29，2： | 1 |
| 7 | A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up 显示文摘 | Bifulco G Mandato V D Mignogna C | 2007 | Int J Gynecol Cancer2007，，： | 1 |
| 8 | Intestinal occlusion caused by malignant neoplasia of the colon-surgical strategy显示文摘 | Corsale I Foglia E Mandato M | 2003 | G Chir2003，24，3： | 1 |
| 9 | Conserved microtubμLe-actin interactions in cell movement and morphogenesis 显示文摘 | Rodriguez OC Schaefer AW Mandato C A | 2003 | Nature cell biology2003，5，7： | 1 |
| 10 | Conserved microtubule – actin interactions in cell movement andmorphogenesis 显示文摘 | RODRIGUEZ O C SCHAEFER A W MANDATO C A | 2003 | Nat Cell Biol2003，5，7： | 1 |
| 11 | Conserved microtubule-actin interactions in cell movement and morphogenesis 显示文摘 | RODRIGUEZ O C SCHAEFER A W MANDATO C A | 2003 | Nature cell biology2003，5，： | 1 |
| 12 | Multiple bowel stenosis and perforation as long-term complications of chemoradiotherapy for advanced cervical cancer in a young woman: case report显示文摘 | Bifulco G Mandato V D Piccoli R | 2008 | Tumori2008，94，4： | 1 |
| 13 | Small cell neuroendo-crine cervical carcinoma with 1-year follow-up:case report and review显示文摘 | Bifulco G Mandato VD Giampaolino P | 2009 | Anticancer Res2009，29，2： | 1 |
| 14 | Effects of lac- tobacillus rhamnosus strain GG in pediatric obobesity- related liver disease显示文摘 | Vajro P Mandato C Licenziati MR | 2011 | J Pediatr Gastroentero| Nutr2011，52，6： | 1 |
| 15 | Intestinal occlusion caused by malignant neoplasia of the colonsurgical strategy显示文摘 | Corsale I Foglia E Mandato M | 2009 | G Chit2009，24，3： | 1 |
| 16 | Huge primary retroperitoneal mucinous cystade- noma of borderline malignancy mimicking an ovarian mass:case report and review 显示文摘 | BIFULCO G MANDATO V D GIAM_ PAOLINO P | 2008 | Anticancer Res2008，28，4： | 1 |
| 17 | Conservedmicrotubule - actin interactions in cell movement and mor-phogenesis 显示文摘 | Rodriguez OC Schaefer AW Mandato CA | 2003 | Nat Cell Biol2003，5，7： | 1 |
| 18 | Huge primary retroperitoneal mucinous cyst adenoma of borderline malignancy mimicking an ovarian mass: case report and review 显示文摘 | Bifulco G Mandato V D Giampaolino P | 2008 | Anticancer Res2008，28，4： | 1 |
| 19 | Osteoporosis and cardiovascular disease:benefit-risk of hormone replacement therapy显示文摘 | Sammartino A Cirillo D Mandato V D | 2005 | J Endocrinol Invest2005，28，10： | 1 |
| 20 | Conserved micro-tubule-actin interactions in cell movement and morphogenesis 显示文摘 | Rodriguez OC Schaefer AW Mandato CA | 2003 | Nat Cell Biol2003，5，7： | 1 |
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