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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies显示文摘Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death.Hepatocellular carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic steatohepatitis.Especially cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved outcome.We here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for surveillance.Ultrasound andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and controversial.Various other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance imaging-scan.Although early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their cost-effectiveness.For the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories. | Suzanne van Meer Robert A de Man Peter D Siersema Karel J van Erpecum | 2013 | World Journal of Gastroenterology2013，19，40： | 10 |
| 3 | The petrogenetic and metallogenetic significance of topaz granite from the SW England orefield 显示文摘 | Manning D A C Hill P I | 1990 | Geol Soc Am Spec Pap1990，246，： | 1 |
| 4 | Urinary leukotriene F4 levels during early and late asthmatic responses 显示文摘 | Manning PJ Rokach J Malo JL Ethier D Cartier A Girard Y Charleson S O'Byrne PM | 1990 | J Allergy Clin Immunol1990，86，2： | 1 |
| 5 | Comparison of geochemical indices used for the interpretation of palaeoredox conditions in ancient mudstones 显示文摘 | Jones B Manning D A C | 1994 | Chemical Geology1994，111，： | 1 |
| 6 | AP-I and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis 显示文摘 | Han Z Boyle D L Manning A M | 1998 | Autoimmunity1998，28，4： | 1 |
| 7 | Use of an extended Kalman filter as a robust tyre force estimator 显示文摘 | WILKIN M A MANNING W J CROLLA D C | 2006 | Vehicle System Dynamics Supplement2006，44，1： | 1 |
| 8 | High performance liquid chromatographic determinations of se- lected gas phase carbonyls in tobacco smoke 显示文摘 | MANNING D L ASKERINEC M P JENKINS R A | 1983 | Journal of Association of Analytical Chemistry1983，66，1： | 1 |
| 9 | Continuous observations of carbon dioxide at Mace Head, Ireland from 1995 to 1999 and its net European ecosystem exchange 显示文摘 | Derwent R Ryall D Manning A | 2002 | Atmospheric Environment2002，36，17： | 1 |
| 10 | Estimating source regions of European emissions of trace gases from observations at Mace Head 显示文摘 | Ryall D B Derwent R G Manning A J | 2001 | Atmospheric Environment2001，35，14： | 1 |
| 11 | Comparison of geochemical indices used for the interpretation of palaeoredox conditions in ancient mud- stones显示文摘 | Jones B Manning D A | 1994 | Chemical Geology1994，111，1： | 1 |
| 12 | Thermochemical sulphate reduction (TSR):Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs显示文摘 | MANNING D A C BOTTRELL S H WORDEN R H | 2004 | Org Geochem2004，35，4： | 1 |
| 13 | Thermochemical sulphate reduction (TSR) :Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reser- voirs 显示文摘 | Cross M M Manning D A C Bottrell S H | 2004 | Organic Geochemistry2004，35，4： | 1 |
| 14 | Speciation of arsenic(III)and arsenic(Y)in sediment extracts by high-performanceliquid chromatography--hydride generation atomicabsorption spectrophotometry显示文摘 | Manning B A Martens D A | 1997 | Environmental Science &Technology1997，31，1： | 1 |
| 15 | Tuberous sclerosis complex-1and-2gene products function together to inhibit mammalian target of rapamycin(mtor)-mediated downstream signaling显示文摘 | Tee A R Fingar D C Manning B D | 2002 | Proc Natl Acad Sci U S A2002，99，13： | 1 |
| 16 | Rapid growth of hydrofluorocarbon 134a and hydrochlorofluorocarbons 141b, 142b, and 22 from advanced global atmospheric gases experiment (AGAGE) observations at Cape Grim, Tasmania, and Mace Head, Ireland 显示文摘 | O'Doherty S Cunnold D M Manning A | | Journal of Geophysical Research0，，： | 1 |
| 17 | 80 Gbit/s all optical regenerative wavelength conversion using semiconductor optical amplifier based interferometer 显示文摘 | Kelly A E Phillips I D Manning R J | 1999 | Electronics Letters1999，35，17： | 1 |
| 18 | Thermochemical sulphate reduction (TSR):Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs 显示文摘 | CROSS M M MANNING D A C BOTTRELL S H WORDEN R H | 2004 | Org Geochem2004，35，4： | 1 |
| 19 | Speciation of arsenic(Ⅲ) and arsenic(Ⅴ) in sediment extracts by high-performance liquid chroma- tography-hydride generation atomic absorption spectrophotometry显示文摘 | MANNING B A MARTENS D A | 1997 | Environment Science Technology1997，31，： | 1 |
| 20 | Assessment of the ecological potential of mine-water treatment wetlands using a baseline survey of macroinvertebrate communities显示文摘 | Batty L C Atkin L Manning D A | 2005 | Environmental Pollution2005，138，： | 1 |
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