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| 1 | Genes and type 2 diabetes mellitus显示文摘 | María T T L | 2005 | Archives of Medical Research2005，36，3： | 1 |
| 2 | Biología de Oxalis latifolia:revisión acerca de su origen,ciclo anual,características biológicas más notables y formas taxonómicas显示文摘 | Aritz R E María L L | 2008 | Agronomía Mesoamericana2008，，02： | 1 |
| 3 | Experimental Evidence in Favor of an Initial One-Electron-Transfer Process in the HeterogeneousPhotocatalytic Reduction of Chromium(Ⅵ) over TiO2显示文摘 | Juan T María A Marta L | 2001 | Langmuir2001，17，12： | 1 |
| 4 | Central venous catheter-related infection in a prospective and observational study of 2,595 catheters显示文摘 | Leonardo L Henry C María MM | | 0，，06： | 1 |
| 5 | A Novel Surgicalapproach to slow-transit constipation:report of two cases显示文摘 | George P Francisca L María EM | | 0，，01： | 1 |
| 6 | Watts theorems for associative rings显示文摘 | García J L Marín L | 2001 | Communications in Algebra2001，29，12： | 1 |
| 7 | Traceability markers to the botanical origin in olive oils显示文摘 | Cristina M María L M A Carmen G R | | 0，，： | 1 |
| 8 | Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression显示文摘Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies. | maría l bacigalupo pablo carabias maría f troncoso | 2017 | World Journal of Gastroenterology2017，23，29： | 11 |
| 9 | Cellular automata model for traffic flow with safe driving conditions显示文摘In this paper, a recently introduced cellular automata(CA) model is used for a statistical analysis of the inner microscopic structure of synchronized traffic flow. The analysis focuses on the formation and dissolution of clusters or platoons of vehicles, as the mechanism that causes the presence of this synchronized traffic state with a high flow. This platoon formation is one of the most interesting phenomena observed in traffic flows and plays an important role both in manual and automated highway systems(AHS). Simulation results, obtained from a single-lane system under periodic boundary conditions indicate that in the density region where the synchronized state is observed, most vehicles travel together in platoons with approximately the same speed and small spatial distances. The examination of velocity variations and individual vehicle gaps shows that the flow corresponding to the synchronized state is stable, safe and highly correlated. Moreover,results indicate that the observed platoon formation in real traffic is reproduced in simulations by the relation between vehicle headway and velocity that is embedded in the dynamics definition of the CA model. | María Elena Lárraga Luis Alvarez-Icaza | 2014 | Chinese Physics B2014，23，5： | 4 |
| 10 | MicroRNAs contribute to ATP-binding cassette transporter-and autophagy-mediated chemoresistance in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) has an elevated mortality rate, largely because of high recurrence and metastasis. Additionally, the main obstacle during treatment of HCC is that patients usually develop resistance to chemotherapy.Cancer drug resistance involves many different mechanisms, including alterations in drug metabolism and processing, impairment of the apoptotic machine, activation of cell survival signaling, decreased drug sensitivity and autophagy, among others. Nowadays, miRNAs are emerging as master regulators of normal physiology-and tumor-related gene expression. In HCC,aberrant expression of many miRNAs leads to chemoresistance. Herein, we particularly analyzed miRNA impact on HCC resistance to drug therapy. Certain miRNAs target ABC(ATP-binding cassette) transporter genes. As most of these miRNAs are downregulated in HCC, transporter levels increase and intracellular drug accumulation decrease, turning cells less sensitive to death. Others miRNAs target autophagy-related gene expression, inhibiting autophagy and acting as tumor suppressors. Nevertheless, due to its downregulation in HCC, these miRNAs do not inhibit autophagy or tumor growth and, resistance is favored.Concluding, modulation of ABC transporter and/or autophagy-related gene expression or function by miRNAs could be determinant for HCC cell survival under chemotherapeutic drug treatment. Undoubtedly, more insights on the biological processes, signaling pathways and/or molecular mechanisms regulated by miRNAs are needed. Anyway, miRNA-based therapy together with conventional chemotherapeutic drugs has a great future in cancer therapy. | María V Espelt María L Bacigalupo Pablo Carabias María F Troncoso | 2019 | World Journal of Hepatology2019，11，4： | 3 |
| 11 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 12 | Abordaje integral d e un caso complejo de diabetes mellitus en domicilio entre la gestora de casos y la enfermera comunitaria显示文摘 | Marta Prats Guardiola Rosa María López Pisa | 2010 | Enfermería Clínica2010，20，2： | 1 |
| 13 | The effect of doping(Mn,B)3O4 materials as protective layers in different metallic interconnects for solid oxide fuel cells显示文摘 | Miguel-Pérez V Martínez-Amesti A María L N | | 0，，： | 1 |
| 14 | Comparative effects of captopril and L-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats显示文摘 | MIGUEL-CARRASCO J L MARíA T Monserrat A M | 2010 | European Journal of Pharmacology2010，632，： | 1 |
| 15 | Genetic polymorphisms and atrial fibrillation:insights into the prothrombotic state and thromboembolic risk显示文摘 | López-Cuenca A Marín F Roldán V | | 0，，08： | 1 |
| 16 | Programmed cell death in seeds of angiosperms显示文摘During the diversi fication of angiosperms, seeds have evolved structural, chemical, molecular and physiologically developing changes that specially affect the nucellus and endosperm. All through seed evolution, programmed cell death(PCD) has played a fundamental role. However,examples of PCD during seed development are limited. The present review examines PCD in integuments, nucellus,suspensor and endosperm in those representative examples of seeds studied to date. | María Paula López-Fernández Sara Maldonado | 2015 | Journal of Integrative Plant Biology2015，57，12： | 1 |
| 17 | Phylogenetic and functional analysis of Arabidopsis RCI2 genes显示文摘 | Joaquín M María L Julio S | 2007 | Journal of Experimental Botany2007，58，： | 1 |
| 18 | Early detection of graft incompatibility in apricot (Prunus armeniaca) using in vitro techniques显示文摘 | Errea P Garay L Marín J A | | 0，，： | 1 |
| 19 | Robust output-feedback model predictive control for systems with unstructured uncertainty显示文摘 | Christian L?vaas María M. Seron Graham C. Goodwin | 2008 | Automatica2008，，8： | 1 |
| 20 | The reduction of dietarysucrose improves dyslipidemia, adiposity and insulin secretion in aninsulin resistant rat model显示文摘 | MARíA A F YOLANDA B L ADRIANA C | 2007 | Nutrition2007，23，6： | 1 |
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