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| 1 | Effect of a bacterial inoculum and additive on dry matter in situ degradability of sugarcane silage显示文摘The objective of this study was to evaluate the effect of adding a bacterial inoculum and a handmade additive to sugarcane silage(SCS) on the in situ digestibility of dry matter(DM). The treatments were: T1) sugarcane silage(SCS) and T2) sugarcane silage with 1% inoculum and 1% additive(SCS+). The bacterial inoculum consisted of 10.0% molasses, 1.0% yogurt, 5.0% chicken manure, 0.5% urea, and 83.0% water, and the additive was formulated with 1.0% urea, 0.1% ammonium sulfate, and 0.25% phosphorus. In situ dry matter digestibility(DMD) was determined using the nylon bag technique with four cows equipped with ruminal fistulas. Cows were fed with ensiled sugarcane supplemented with 1 kg of commercial concentrate. 5 g of ground sample for each sugarcane treatment were weighted in nylon bags and incubated for 4, 8, 12, 24, 48, and 72 h in a completely randomized design with six replicates. The DMD(%) was higher(P<0.05) for SCS+ for all incubation times when compared with SCS. There were no differences in ruminal p H between the treatments for all the incubation times. The data suggested that the sugarcane silage with bacterial inoculum and additive could be an alternative for providing forage for ruminants during the season of low growth and quality grass. | José A Reyes-Gutiérrez Oziel D Montaez-Valdez Ramón Rodríguez-Macias Mario Ruíz-López Eduardo Salcedo-Pérez Cándido E Guerra-Medina | 2015 | Journal of Integrative Agriculture2015，14，3： | 3 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 4 | A method for calibration and validation subset partitioning显示文摘 | ROBERTO K H G MARIO C U A GLEDSON E J | 2005 | Talanta2005，67，4： | 1 |
| 5 | Drug safety evaluation of olanzapine/fluoxetine combination显示文摘 | Mario A Cristancho Michael E Thase | 2014 | Expert Opinion on Drug Safety2014，，8： | 1 |
| 6 | Endometrial dating and determination of the window of implantation in healthy fertile women显示文摘 | Anibal A Laura E Mario B | 2000 | Fertil Steril2000，73，4： | 1 |
| 7 | Blood pressure and body water distribution in chronic renal failure patients显示文摘 | Maria A Alejandro M Mario E | 2001 | Nephrol Dial Transplant2001，16，1： | 1 |
| 8 | Processing of cassava roots to remove cyanogens显示文摘 | Paula C A Estevao M Mario E | | 0，，05： | 1 |
| 9 | Defect - determined regeneration options for treating periodontal intrabony defects in baboons 显示文摘 | BLUMENTHAL NEIL M ALVES MARIO E A F AL- HUVAIS SALAH | 2003 | J Periodontol2003，74，1： | 1 |
| 10 | Endometrial dating and determination of the window of implantation in healthy fertile women显示文摘 | Anibal A Laura E Mario B | 2000 | Fertil Steril2000，73，4： | 1 |
| 11 | Endometrial dating and determination of the window of implantation in healthy fertile women显示文摘 | Anibal A Laura E Mario B | | 0，，04： | 1 |
| 12 | A fuzzy approach on image complexity measure 显示文摘 | Mario I C M Luis E A D Abdi D S | 2007 | Computaci6n y Sistemas2007，10，3： | 1 |
| 13 | Epigallocate- chin-3-gallate(EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation显示文摘 | Albrecht D S Clubbs E A Mario F | 2008 | ChemicoBiological Interactions2008，171，1： | 1 |
| 14 | Does Firm Size Affect Self?selction and Learning-by-exporting?显示文摘 | JUAN A MARIo E MoNEZ-CASTILLEJO ROCHINA-BARRACHINA JUAN A SANCHIS-LLOPIS | 2010 | The World Economy2010，33，3： | 1 |
| 15 | Endometrial dating and determination of the window of implantation in healthy fertile women显示文摘 | Anibal A Laura E Mario B | 2000 | Fertil Steril2000，73，4： | 1 |
| 16 | Effect of temperature on oxygen consumption and ammonia excretion in the Calafia mother-of-pearl oyster,Pinctada mazatlanica(Hardey,1856)显示文摘 | Saucedo E Lucl'a Ocampo Mario Monteforte | 2004 | Aquaculture2004，229，： | 1 |
| 17 | A variable elimination method to improve the parsimony of MLR models using the successive projections algorithm显示文摘 | Roberto K H G Mario C U A Wallace D F Edvan C S Gledson E J Sofacles F C S Henrique M P | 2008 | Chemometrics and Intelligent Laboratory Systems2008，92，： | 1 |
| 18 | Signal space diversity augmented space time block coded communication system显示文摘 | Mario E Magan A Pichalinee Kanivichaporn | 2006 | Wireless Personal Communications2006，39，： | 1 |
| 19 | Effect of temperature on oxygen consumption and ammonia excretion in the Calafia mother-of-pearl oyster,Pinctada mazatlanica(Hanley,1856)显示文摘 | Saucedo E Lucl'a Ocampo Mario Monteforte | 2004 | Aquaculture2004，229，： | 1 |
| 20 | Monolithic reactors for environmental applications: a review on preparation technologies 显示文摘 | Pedro A Mario M Eduardo E M | 2005 | Chemical Engineering Journal2005，109，： | 1 |
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