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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 3 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 4 | The effect of allochthonous salt on the petroleum systems of northern Green Canyon and Ewing Bank (offshore Louisiana),northern Gulf of Mexico显示文摘 | Paul W Mark G R | 1998 | AAPG Bulletin1998，82，5： | 1 |
| 5 | Creating safer workplaces: assessing the determinants and role of safety climate 显示文摘 | DAVID M D BRYAN S S MARK G W | 2004 | Journal of Safety Research2004，35，1： | 1 |
| 6 | Near infrared spectroscopy in patient with sever brain injury and elevated ICP:a pilot study显示文摘 | Melville S Mark G | 1997 | Acta Neurochir Suppl(wien)1997，70，1： | 1 |
| 7 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 8 | KRAS mutations in non-small cell lung cancer 显示文摘 | Riely G J Marks J Pao W | 2009 | Proc Am Thorac Soc2009，6，2： | 1 |
| 9 | Data Storage and Extraction in Engineering Software Using XML显示文摘 | Mark E W Consolazio G R Hoit M I | 2003 | Advances in Engineering Software2003，36，1112： | 1 |
| 10 | Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and he- modynmaics 显示文摘 | MeCormiek P W Melville S Mark G G | 1991 | Critical Care Medicine1991，19，1： | 1 |
| 11 | Studies of degradation enhancement of polystyrene by flame retardant addi- tives 显示文摘 | Mark W Beach Nelson G Rondan Robert D Froese | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 12 | Synthesis and characterization of fillers of controlled structure based on polyhedral oligomeric silsesquioxane cages and their use in reinforcing siloxane elastomers显示文摘 | Pan G R Mark J E Schaefer D W | 2003 | J Polym Sci2003，41，： | 1 |
| 13 | The role of three dimensional functional lung in radiation treatment planning:the functional dose-volume histogram显示文摘 | Marks L B Spencer D P Sherouse G W | 1995 | Int J Radiat Onco Biol Phys1995，33，： | 1 |
| 14 | Evaluation of a commercially available radioimmunoassay kit for measurement of doxorubicin in plasma 显示文摘 | Piall E Aherne G W Marks V | 1982 | Clin Chem1982，28，1： | 1 |
| 15 | Gene expression polymor- phisms and ESTs associated with gravitropic response of subterranean branch meristems and growth habit in Leymus wildryes]显示文摘 | Parminder K Ivan W M Steven R L Bushman B S Alvaro G H Kim W R Liu L Mark A M | 2008 | Plant Science2008，175，3： | 1 |
| 16 | Evaluation of a commercial available radioimmunoassay kit for measurement of doxorubicin in plasma显示文摘 | PIALL E AHERNE G W MARKES V | 1982 | Clin Chem1982，28，1： | 1 |
| 17 | A neutralizing epitope of human papillomavirus type 11 is prineipally described by a continuous set of residues which overlap a distinct linear, surface-exposed epitope显示文摘 | Ludmerer S W Benineasa D Mark G E | 1997 | J Virol1997，71，5： | 1 |
| 18 | Preparation and characterization of some unusually transparent poly (dimethylsiloxane) nanocomposites 显示文摘 | Rajan G S Sur G S Mark J E Schaefer D W Beaucage O | 2003 | Journal of Polymer Science Part B: Polymer Physics2003，41，16： | 1 |
| 19 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 20 | Numerical investigation of a developmental pneumatically fed impact pulveriser显示文摘 | Ioannis G Chatzilamprou Michael J Tierney Mark W Youds | 2006 | Applied Mathematical Modelling2006，，30： | 1 |
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