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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Alpha-actinin-4 is required for normal podocyte adhesion显示文摘 | DANDAPANI S V SUGIMOTO H MATTHEWS B D | 2007 | J Biol Chem2007，282，1： | 1 |
| 5 | Data mining for simple sequence repeats in expressed sequence tags from barley,maize,rice,sorghum and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，： | 1 |
| 6 | Data mining for simple sequence repeats in expressed sequence tags from barley显示文摘 | Kantety R V La Rota M Matthews D E | 2002 | Plant Mol Biol2002，48，56： | 1 |
| 7 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat 显示文摘 | KANTETY R V LA ROTA M MATTHEWS D E | 2002 | Plant Molecular Biology2002，48，5： | 1 |
| 8 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0，，： | 1 |
| 9 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，： | 1 |
| 10 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | Kantety R V La Rota M Matthews D E Sorrells M E | 2002 | Plant Mol Biol2002，48，： | 1 |
| 11 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat 显示文摘 | KANTETY R V LA ROTA M MATTHEWS D E | 2002 | Plant Molecular Bi- ology2002，48，： | 1 |
| 12 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, riee, sorghum and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Molecular Biology2002，48，： | 1 |
| 13 | Data mining of simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | KANTETY R V LA ROTA M MATTHEWS D E SORRELLS M E | 2002 | Plant Molecular Biology2002，148，56： | 1 |
| 14 | Alpha?actinin-4 is required for normal podocyte adhesion显示文摘 | Dandapani S V Sugimoto H Matthews B D | 2007 | J Bioi Chern2007，282，1： | 1 |
| 15 | High throughput electrochemi- cal observation of structural phase changes in LiFe1-x MnxPO4 during charge and discharge 显示文摘 | Matthew R R Girts V Guy D | 2010 | J Electrochem Soc2010，157，4： | 1 |
| 16 | Risk factors affecting operating approach,conversion,and morbidity for adrenalectomy:a single institusion series of 402patients显示文摘 | Bittner J G 4th Gershuni V M Matthews B D | 2013 | Surg Endosc2013，7，27： | 1 |
| 17 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum, and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，4： | 1 |
| 18 | Data mining for simple sequence repeats in expressed sequence tags from barley,maize,rice,sorghum and wheat显示文摘 | Kantety R V La R M Matthews D E | 2002 | Plant Molecular Biology2002，48，： | 1 |
| 19 | Laparo- scopic radical nephrectomy 显示文摘 | MATTHEW D D ELSPETH M M FRCSC V C | 2000 | J Endourology2000，14，10： | 1 |
| 20 | Data mining forsimple sequence repeats in expressed sequence tags from barley,maize, rice, sorghum and wheat 显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，50： | 1 |
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