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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022,7,2: | 7 |
| 2 | Proteins complexed to the P1 adhesinofMycoplasmapneumoniae显示文摘 | Gerlinde LS Alexandre P Matthias M | 2000 | Microbiology2000,146,: | 1 |
| 3 | An attempt to close the daytime surface energy 显示文摘 | Matthias M Raymond L D Elizabeth P | 2010 | Boundary-Layer Meteorology2010,136,2: | 1 |
| 4 | Rapid detection of octamer binding proteins with 'mini-extracts',prepared from a small number of cells显示文摘 | Matthias P Müller MM | 1989 | Nucleic Acids Res1989,17,: | 1 |
| 5 | Rapid detection of octamer binding proteins with mini-extracts prepared from a small number of cells显示文摘 | Schreiber E Matthias P Mithaeel M | 1989 | Nucl Acid Res1989,17,: | 1 |
| 6 | Rapid detection of octamer binding proteins with mini-extracts prepared from a small number of cells 显示文摘 | Schreiber E Matthias P Mithaeel M | 1989 | Nucl Acid Res1989,17,15: | 1 |
| 7 | High accuracy spline interpolation for 5-axis machining显示文摘 | Matthias Müller Gábor Erds Xirouchakis P | 2004 | Computer-Aided Design2004,36,13: | 1 |
| 8 | HDAC6 a new cellular stress surveillance factor显示文摘 | Matthias P Youshida M Khochbin S | 2008 | Cell Cycle2008,7,1: | 1 |
| 9 | Rapid detection of actamer binding proteins with mini-extracts,prepared from a small number of cells显示文摘 | Schreiber E Matthias P Michael M | 1989 | Nucleic Acids Research1989,17,15: | 1 |
| 10 | Rapid detection of octamer binding proteins with' mini-extracts' ,prepared from a small number of cells 显示文摘 | Schreiber E Matthias P Mailer M M | 1989 | Nucleic Acids Res1989,17,15: | 1 |
| 11 | Rapid detection of octamer binding proteins with 'mini-extracts' ,prepared from a small number of cells 显示文摘 | Schreiber E Matthias P Maller M M | 1989 | Nucleic Acids Res1989,17,15: | 1 |
| 12 | Protein complexed to the P1 adhesin of Mycoplasma pneumoniae显示文摘 | Gerlinde LS Alexande P Matthias M | 2000 | Microbiology2000,146,: | 1 |
| 13 | HDAC6 a new cellular stress surveillance factor 显示文摘 | Matthias P Yoshida M Khochbin S | 2008 | Cell Cycle2008,7,1: | 1 |
| 14 | Rapid detection of octamer binding protein with ' mini-extracts', prepared from a small number of cells显示文摘 | Schreiber F Matthias P Müller MM | 1989 | Nucleic Acids Reseach1989,17,15: | 1 |
| 15 | Glycerol: A Promising and Abundant Carbon Source for Industrial Microbiology显示文摘 | Gervasio D S P Matthias M Contiero J | 2009 | Biotechnology Advances2009,27,1: | 1 |
| 16 | Study ofdynamic multi-dimensional temperature and concentration distributionin liquid-sprayed fluidized beds 显示文摘 | Stefan H Jan B Markus H Matthias I Mirko P Lothar M | 2003 | Chemical Engineering Science2003,23,58: | 1 |
| 17 | The telomerase-associated protein P43 is involved in anchoring telomerase in the nucleus显示文摘 | Matthias M Jan P Katrin P | 2003 | J Cell Sci2003,116,9: | 1 |
| 18 | Austenite Formation in Plain Low - Carbon Steels 显示文摘 | Hamid A A Matthias M Warren J P | 2011 | Metallurgical and Materials Transactions A2011,42,6: | 1 |
| 19 | Value and limitations of immunohistochemistry and gene sequencing for detection of the IDH1-R132H mutation in diffuse glioma biopsy specimens显示文摘 | Matthias P M Adelheid W | | 0,,: | 1 |
| 20 | HDAC6 a new cellular stress surveillance factor显示文摘 | Matthias P Youshida M Khochbin S | 2008 | Cell Cycle2008,7,1: | 1 |