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| 1 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 2 | leaves grown at sub-optimal temperature显示文摘 | Haldimann P Fracheboud Y Stamp E Photosynthetic performance and resistance to photoinhibition of Zea mays L | 1996 | Plant Cell Envrionment1996，19，： | 1 |
| 3 | Structural stability of infinite-layer CaCuO_2 under high pressure显示文摘In situ high-pressure energy dispersive X-ray diffraction measurements on polycrystalline powder Ca-CuO2 with an infinite layer structure (IL CaCuO2) have been performed by using diamond anvil cell (DAC) instrument with synchrotron radiation. The results suggest that the crystal structure of IL CaCuO2 is stable under pressure up to 30 GPa at room temperature. According to Birch-Murn- aghan equation of state, assuming pressure derivative 4,=0Bthe bulk modulus B0=181 ?9 GPa is obtained. | QIN Xiaomei1,2, HONG Ming1,2, ZHANG Gongmu1,2, MAI Wenjie1,2, LI Fengying1,2, YU Richeng1,2, LIU Jing2,3 & JIN Changqing1,2 1. Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China 2. Beijing High Pressure Research Center, Beijing 100080, China 3. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China Correspondence should be addressed to Jin Changqing (e-mail: cqjin@ aphy.iphy.ac.cn) | 2003 | Chinese Science Bulletin2003，48，12： | 1 |
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