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64篇 您的检索式：作者名="Mcelduff A"

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	题名	作者	年代	出处	被引量
1	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
2	A method for meta-analysis of molecular association studies显示文摘	Thakkinstian A McElduff P D~Este C	2005	Stat Med2005，24，：	1
3	Current smoking and the risk of non-fatal myocardial infarction in the WHO MONICA Project populations显示文摘	Mahonen M S McElduff P J Dobson A	2004	Tob Control2004，13，：	1
4	Vitamin D and pregnancy:An old problem revisited显示文摘	Barrett H McElduff A	2010	Best Pract Res Clin Endocrinol Metab2010，24，：	1
5	Pulmonary insulin administration using the AERx system: physiological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects 显示文摘	Farr SJ Mcelduff A MatherLE	2000	Diabetes Technol Ther2000，2，2：	1
6	Maternal vitamin D deficiency, ethnicity and gestational diabetes显示文摘	Clifton-Bligh R J McElduff P McElduff A	2008	Diabet Med2008，25，6：	1
7	A method for meta analysis of molecular association studies 显示文摘	Thakkinstian A McElduff P D'Este C	2005	Star Med2005，24，：	1
8	Defining the extent of irreversible brain ischemia using perfusion computed tomography显示文摘	Bivard A McElduff P Spratt N		0，，03：	1
9	The relationship among homocysteine,creatinine clearance,and albuminuria in patients with type 2 diabetes显示文摘	Davies L Wilmshurst EG McElduff A	2001	Diabetes Care2001，24，：	1
10	Pregestational diabetes in pregnancy : an Australian experience 显示文摘	McElduff A Ross GP Lagstrom J	2005	Diabetes Care2005，28，5：	1
11	Defining the extent of irreversible brain ischemia using perfusion computed tomography显示文摘	BIVARD A MCELDUFF P SPRATT N	2011	Cerebrovasc Dis2011，31，3：	1
12	Does Graves disease or thyrotoxicosis affect the prognosis of thyroid cancer显示文摘	Hales I B McElduff A Crummer P		0，，03：	1
13	Vitamin D and pregnancy: an old problem revisited显示文摘	BARRETT H MCELDUFF A	2010	Best Practice & Research Clinical Endocrinology Metabolism2010，24，4：	1
14	Maternal vitamin D deficiency, ethnieity and gestati0na\| diabetes 显示文摘	Clifton-Bligh R J McE\|duff P McElduff A	2008	Diabe! Med2008，25，：	1
15	Insulin levels in insu-lin resistance:Phantom of the metabolic opera显示文摘	Samaras K McElduff A Twigg SM	2006	Med J Aust2006，185，3：	1
16	Medical disorder of adults with mental retardation:a population study显示文摘	Beange H McElduff A Baker W	1995	American Jour nal on Mental Retardation1995，99，：	1
17	A method for meta- a- nalysis of molecular association studies 显示文摘	Thakkinstian A McElduff P D'Este C	2005	Statistics in Medicine2005，24，9：	1
18	Current smoking and the risk of non-fatal myocardial infarction in the WHO MONICA Project populations显示文摘	Mahonen MS Mcelduff P Dobson A J	2004	Tob Control2004，13，3：	1
19	A method for me-ta-analysis of molecular association studies显示文摘	Thakkinstian A McElduff P D’Este C	2005	Statistics in Medi-cine2005，24，9：	1
20	Medical disorders of adults with mental retardation:a population study显示文摘	BEANGE H MCELDUFF A BAKER W	1995	Am J Ment Retard1995，99，：	1

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