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| 1 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 2 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 3 | Accelerated degradation tests:Modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu C J | 1998 | Technometrics1998，40，： | 1 |
| 4 | Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus显示文摘 | Barrat F J Meeker T Gregorio J | 2005 | J Exp Med2005，202，8： | 1 |
| 5 | Experimental atherosclerosis and high protein diets显示文摘 | Meeker D R Kesten H D | 1940 | Proceedings of the Society for Experimental Biology and Medicine1940，45，： | 1 |
| 6 | Accelerated degradation tests:modeling and analysis显示文摘 | Meeker W Q Escobar L A Lu J C | 1998 | Technometrics1998，40，2： | 1 |
| 7 | Major features and forcing of high-resolution Northern Hemisphere chemical series 显示文摘 | Mayewiski P A Meeker L D Twickler M S | 1997 | Journal of Geophysical Researcher1997，102，26： | 1 |
| 8 | Pennyroyal toxicity:measurement of toxic metabolite levels in two cases and review of the literature显示文摘 | Anderson I B Mullen W H Meeker J E | 1996 | Ann Intern Med1996，124，8： | 1 |
| 9 | Statistical tools for the rapid development & evaluation of high-reliability products 显示文摘 | MEEKER W Q HAMADA M | 1995 | IEEE Trans on Reliability1995，44，2： | 1 |
| 10 | Phthalates and otherad- ditives in plastics: human exposure and associated health outcomes 显示文摘 | Meeker JD Sathyanarayana S Swan SH | 2009 | Philos Trans R Soc Lond B Biol Sci2009，364，： | 1 |
| 11 | Presentation and management of bronchogenic cysts in the adult 显示文摘 | Patel SR Meeker DP Biscotti CV | 1994 | Chest1994，106，1： | 1 |
| 12 | Statistical tools for the rapid develop- ment & evaluation of high - reliability products 显示文摘 | Meeker W Q Hamada M | 1995 | IEEE Transactions on Reliability1995，44，2： | 1 |
| 13 | Detecting crack s in aircraf t engine fan blades using vibrothermography nondestructive evaluation显示文摘 | GAO C W MEEKER W Q Mayton D | 2014 | Reliability Engineering and System Safety2014，，131： | 1 |
| 14 | Shortened telomeres in serous tubal intraepithelial carcinoma:an early event in ovarian high-grade serous carcinogenesis显示文摘 | Kuhn E Meeker A Wang TL | 2010 | Am J Surg Pathol2010，34，6： | 1 |
| 15 | Increased dietary vitaminD suppresses MAPK signaling, colitis, and colon cancer 显示文摘 | Meeker S Seamons A Paik J | 2014 | Cancer Res2014，74，16： | 1 |
| 16 | Using degradation measures to estimate a time-to-failure distribution显示文摘 | Meeker W Q | 1993 | Technometrics1993，35，2： | 1 |
| 17 | Complexity of Holocene Climate as Reconstructed from a Greenland ice Core显示文摘 | O'Brien S R Mayevoski P A Meeker L D | 1995 | Science1995，270，： | 1 |
| 18 | Telomerase as drug and drug target for the treatment of thyroid cancer 显示文摘 | Zeique MA Meeker AK | 2004 | Curr Drug Targets Immune Endocr Metabol Disord2004，4，3： | 1 |
| 19 | Mast cell-cholinergic nerve interaction in mouse airways 显示文摘 | Weigand L A Myers A C Meeker S | 2009 | J Physiol2009，587，13： | 1 |
| 20 | Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites显示文摘 | HAUSER R MEEKER J D DUTY S | 2006 | Epidemiology2006，17，： | 1 |
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