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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 3 | Identification of a Spindlin homolog in gibel carp(Carassius auratus gibelio)显示文摘 | Wang X L Sun M Mei J | 2005 | Comp Biochem Physiol2005，141，： | 1 |
| 4 | LED-induced fluor escence system for tea classification and quality assessment 显示文摘 | DONG YJ LIU X MEI L | 2014 | J Food Eng2014，137，： | 1 |
| 5 | Enhanced paclitaxel production induced by the combination of elicitors in cell suspension cultures of Taxus chinensis 显示文摘 | Zhang C H Mei X G Yu L J | 2000 | Biotechnol Lett2000，22，19： | 1 |
| 6 | A fractional gradient representation of the Poincar~ equations 显示文摘 | CHEN X W ZHAO G L MEI F X | 2013 | Nonlinear Dynamics2013，73，： | 1 |
| 7 | Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio,activation of caspase-3/8/9,and downregulation of the Akt显示文摘 | Du L Mei H F Yin X | 2014 | Tumor Biol2014，35，3： | 1 |
| 8 | Environmental performance testing system for thermostructure materials applied in aeroengines显示文摘 | Zhang L T Cheng L F Luan X G Mei H Xu Y D | 2006 | Key Eng Mat2006，313，： | 1 |
| 9 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | ENKE L YAN C R MEI X R | 2010 | Geoderma2010，158，34： | 1 |
| 10 | Statistical tests for spatial nonstationarity based on the geographically weighted regression model显示文摘 | Leung Y Mei C L Zhang W X | 2000 | Environment and Planning A2000，32，1： | 1 |
| 11 | Strong blue emission from anodic alumina membranes with ordered nanopore array显示文摘 | Huang G S Wu X L Mei Y F | 2003 | Journal of Applied Physics2003，93，： | 1 |
| 12 | From Si nanotubes tonanowires:synthesis,characterization,and self-assembly显示文摘 | QIU T WU X L MEI Y F | 2005 | Journal of Crystal Growth2005，277，1234： | 1 |
| 13 | Expression of oxidored nitro domain- containing protein 1 ( NOR1 ) impairs nasopharyngeal carcinoma cells adaptation to hypoxia and inhibits PDK1 expression 显示文摘 | Bo X Mei Y Wen J L | 2014 | Mol Cell Biochem2014，393，2： | 1 |
| 14 | Statistical tests for spatial nonstationarity based on the geographically weighted regression model 显示文摘 | Leung Y Mei C L and Zhang W X | 2000 | Environment and Planning A2000，32，： | 1 |
| 15 | Quantification of N20 fluxes from soil-plant systems may be biased by the applied gas ehromatograph methodology显示文摘 | Zheng X H Mei B L Wang Y H | 2008 | Plant and Soil2008，311，1： | 1 |
| 16 | Simultaneous tracking and clas- sification: a modularized scheme 显示文摘 | Mei W Shan G L Li X R | 2007 | IEEE Trans on AES2007，43，2： | 1 |
| 17 | Model for predicting displacement-dependent lateral earth pressure显示文摘 | MEI G X CHEN Q M SONG L H | 2009 | Canadian Geotechnical Journal2009，46，： | 1 |
| 18 | Aspisol inhibits tumor growth and induces apoptosis in breast cancer 显示文摘 | Zhu X G Tao L Mei Z R | 2008 | Exp Oncol2008，30，4： | 1 |
| 19 | Investigation of Ni3Al-matrix Composites Strengthened by TiC显示文摘 | Mei B C Yuan R Z Duan X L | 1993 | J Mater Res1993，8，： | 1 |
| 20 | Strong blue emission from anodic alumina membranes with ordered nanopore array显示文摘 | Huang G S Wu X L Mei Y F | 2003 | Journal of Applied Physics2003，93，1： | 1 |
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