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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A:Statistical Mechanics and its Applications1998，261，3： | 1 |
| 3 | Ectopic preg- nancies in a caesarean scar: review of the medical approach to an iatrogenic complication显示文摘 | Mayrnon R Halperin R Mend|ovic S eta| | 2004 | Hum Reprod Update2004，10，： | 1 |
| 4 | Obstruction of pipelines due to paraffin deposition during the flow of crude oils显示文摘 | Ribeiro F S Mendes P R S Braga S L | 1997 | International Journal of Heat Mass Transfer1997，18，1： | 1 |
| 5 | Modeling and ride-through control of doubly fed induction generators during symmetrical voltage sags显示文摘 | Mendes V F de Sousa C V Silva S R | 2011 | IEEE Transactions on Energy Conversion2011，26，4： | 1 |
| 6 | Free and Conjugated Biogenic Amines in Green and Roasted Coffee Beans显示文摘 | Casal S Mendes E Alves M R | 2004 | Journal of Agricul- tural and Food Chemistry2004，，20： | 1 |
| 7 | Membrane ultrafiltration of crude soybean oil显示文摘 | Alicieo T V R Mendes E S | 2002 | Desalination2002，，148： | 1 |
| 8 | Gas displacement of viscoplastic liquids in capillary tubes 显示文摘 | De Souza MENDES P R DUTRA E S S SIFFERT J R R | 2007 | Journal of Non-Newtonian Fluid Mechanics2007，145，1： | 1 |
| 9 | Liquid displacement during oil well cementing operations 显示文摘 | Dutra E S S Naccache M F Mendes P R S | 2004 | Annual Transactions of the Nordic Rheology Society2004，12，1： | 1 |
| 10 | A method for staining nematode secretions and structure 显示文摘 | PREMACHANDREM D MENDE N V HUSSEY R S | 1988 | Journal of Nematology1988，20，1： | 1 |
| 11 | Organic dye for highly efficient solid-state dye-sensitized solar cells显示文摘 | MENDE L S BACH U BAKER R H | 2005 | Adv Mater2005，17，7： | 1 |
| 12 | q-Exponential,Weibull,and q-Weibull Distributions:An Empirical Analysis显示文摘 | MENDES R S MALACARNE L C | 2003 | Physica A2003，324，34： | 1 |
| 13 | Biocompatibility testing of novel starch-based materials with potential ap- plication in orthopaedic surgery:a preliminary study 显示文摘 | Mendes S C Reis R L Bovell Y P | 2001 | Biomaterials2001，22，14： | 1 |
| 14 | Fractionalorder control and simulation of wind energy systems with PMSG/full-power converter topology显示文摘 | Melício R Mendes V M F Catal觔o J P S | 2010 | Energy Conversion and Management2010，51，： | 1 |
| 15 | Liquiddisplacement during oil well cementing operations显示文摘 | DUTRA E S S NACCACHE M F MENDES P R S | 2004 | Annual transactions of the Nordic Rheology Society2004，12，1： | 1 |
| 16 | Power converter topologies for wind energy conversion systems:Integrated modeling,control strategy and performance simulation显示文摘 | Mel cio R Mendes V M F Catal o J P S | 2010 | Renewable Energy2010，35，10： | 1 |
| 17 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A1998，261，3： | 1 |
| 18 | Resistive force of wax deposits during pigging operations显示文摘 | MENDES P R S BRAGA A M B AZEVEDO L F A | 1999 | J Energy Resour-ASME1999，121，3： | 1 |
| 19 | Evaluation of lasting effects of heat stress on sperm profile and oxidative status of ram semen and epididymal sperm显示文摘 | HAMILTON T R MENDES C M DE CASTRO L S | 2016 | Oxid Med Cell Longev2016，2016，16： | 1 |
| 20 | DynDE: A differential evolution for dynamic optimization problems显示文摘 | Mendes R Mohais A S | 2005 | Proceedings of the Congress on Evolutionary Computation Edinburgh UK2005，3，： | 1 |
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