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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A:Statistical Mechanics and its Applications1998，261，3： | 1 |
| 3 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 4 | Numerical simulation of reactive transfers in spouted beds at high temperature:application to coal gasification显示文摘 | Mendes A Dollet A Ablitzer C | 2008 | Journal of Analytical and Applied Pyrolysis2008，82，1： | 1 |
| 5 | Effects of the glyphosate-resistance gene and herbicides on soybean: Field trials monitoring biological nitrogen fixation and yield显示文摘 | Hungria M Mendes I C Nakatani A S | 2014 | Field Crops Research2014，158，： | 1 |
| 6 | Nano- composite acrylic paint with self-cleaning action显示文摘 | CARNEIRO C VIEIRA R MENDES A M | 2012 | Jour- nal of Coatings Technology and Research2012，9，6： | 1 |
| 7 | Prediction of success in external cephalic version under toco- lysis: still a challenge显示文摘 | VAZ DE MACEDO C CLODE N MENDES DA GRA A L | 2015 | Acta Medica Portuguesa2015，28，5： | 1 |
| 8 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 9 | Using immunology principles for fault detection显示文摘 | BRANCO P J C DENTE J A MENDES R V | 2003 | IEEE Transactions on Industrial Electronics2003，50，2： | 1 |
| 10 | Oxygen separation from air by PSA: modelling and experimental results part I: isothermal operation 显示文摘 | MENDES A M M COSTA C A V RODRIGUES A E | 2001 | Separation and Purification Technology2001，24，： | 1 |
| 11 | Failure modes and effects analysis in the prescription, validation and dispensing process显示文摘 | Delgado Silveira E Alvarez Di az A P6 rez Mend ndez-Conde C et al | 2012 | Farm Hosp2012，36，1： | 1 |
| 12 | Removal of acetone, ethyl acetate and ethanol vapors from air using a hollow fiber PDMS membrane module 显示文摘 | Gales G Mendes A Costa C | 2002 | J Membr Sci2002，197，： | 1 |
| 13 | Growth and fermentation patterns of Saccharomyces cerevisiae under different ammonium concentrations and its implications in winemaking industry显示文摘 | Mendes F A Mendes F A Leito C | 2004 | Journal of Applied Microbiology2004，97，3： | 1 |
| 14 | Paraquat(PQ)-pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats显示文摘 | Lacerda A C Rodrigues-Machado Mda G Mendes P L | 2009 | J Toxicol Sci2009，34，6： | 1 |
| 15 | A Numerical Study of the Stability of One-Dimensional Laminar Premixed Flames in Inert Porous Media 显示文摘 | Mendes M A A Pereira J M C Pereira J C F | 2008 | Combustion and Flame2008，153，52： | 1 |
| 16 | Microbial biomass and activities in soil aggregates affected by winter cover crops 显示文摘 | MENDES I C BANDICK A K DICK R P | 1999 | Soil Science Society of America Journal1999，63，4： | 1 |
| 17 | Microbial biomass and activities in soil aggregates by winter cover crops显示文摘 | Mendes C Bandick A K Dick R P | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 18 | Antimicrobial in vitro activity of quinupristin/dalfopristin against Gram-positive cocci isolated from 5 Brazilian centers: results from the Local SMART (LSMART) surveillance study 显示文摘 | MENDES C S1NTO S HSIUNG A | 2002 | J Bras Patol Med Lab2002，38，3： | 1 |
| 19 | The MADS box genes SEEDSTICK and ARABIDOPSIS Bsister play a ma- ternal role in fertilization and seed development 显示文摘 | Mizzotti C Mendes M A Caporali E | 2012 | Plant J2012，70，3： | 1 |
| 20 | Quality characteristics of high pressure-induced hake (Merluccius capensis) protein gels with and without MTGase 显示文摘 | Cardoso C L Mendes R O Saraiva J A | 2010 | Journal of Aquatic Food Product Technology2010，19，34： | 1 |
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