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| 1 | Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease显示文摘Gastro-esophageal reflux disease(GERD)is one of the most prevalent chronic diseases.Although proton pump inhibitors(PPIs)represent the mainstay of treatment both for healing erosive esophagitis and for symptom relief,several studies have shown that up to 40%of GERD patients reported either partial or complete lack of response of their symptoms to a standard PPI dose once daily.Several mechanisms have been proposed as involved in PPIs resistance,including ineffective control of gastric acid secretion,esophageal hypersensitivity,ultrastructural and functional changes in the esophageal epithelium.The diagnostic evaluation of a refractory GERD patients should include an accurate clinical evaluation,upper endoscopy,esophageal manometry and ambulatory pH-impedance monitoring,which allows to discriminate non-erosive reflux disease patients from those presenting esophageal hypersensitivity or functional heartburn.Treatment has been primarily based on doubling the PPI dose or switching to another PPI.Patients with proven disease,not responding to PPI twice daily,are eligible for anti-reflux surgery. | Michele Cicala Sara Emerenziani Michele Pier Luca Guarino Mentore Ribolsi | 2013 | World Journal of Gastroenterology2013，19，39： | 38 |
| 2 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 3 | SOC集成电路设计的新纪元显示文摘介绍了SOC集成电路设计的方法,过程。 | Mentor Graphiss | 2001 | 半导体技术2001，，7： | 7 |
| 4 | Antipsychoti-c-induced weight gain:a comprehensive research synthesis显示文摘 | ALISON DB MENTORE JL MOONSEONG H | | 0，，： | 1 |
| 5 | Antipsychotic- induced weight gain:a comprehensive research synthesis显示文摘 | ALLISON D B MENTORE J L HEO M | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 6 | Antipsychotic- induecd weight gain:a comprehensive research synthesis显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 7 | An tip sychotic - induced weight gain : a comprehensive research synthesis显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychiat ry1999，156，： | 1 |
| 8 | Antipsychotic-induced weight gain: A comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 9 | Antipsychotic-induced weight gain: a comprehensive research synthesis显示文摘 | Allison DB Mentore JL Moonseong H | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 10 | Antipsychotic-induced weight gain:a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychiatry1999，156，： | 1 |
| 11 | Antipsychotieinduced weight gain: A comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 2005 | Am J Psychiatry2005，156，11： | 1 |
| 12 | Antipsychotic -- induced weight gain a comprehensive research synthesis显示文摘 | Allison D B Mentore J L Heo M | 1999 | Am J Psychiat1999，156，11： | 1 |
| 13 | Antipschotic -induced weight gain; a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Moonseong H | 1999 | Am J Psychiatry1999，156，： | 1 |
| 14 | Study of the reuse of treat- ed wastewater on waste container washing vehicles 显示文摘 | Mentore V Francesca G | 2013 | Waste Management2013，33，2： | 1 |
| 15 | Antipsychotic-in- duced weight gain: a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychiatry1999，156，： | 1 |
| 16 | Antipsyehotic - induced weight gain : a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psychia- try1999，156，11： | 1 |
| 17 | Antipsyehotic-induced weight gain : a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Am J Psy- chiatry1999，156，11： | 1 |
| 18 | Antipsychotic-induced weight gain : a comprehensive research synthesis 显示文摘 | Allison DB Mentore JL Heo M | 1999 | Amer J Psychiatry1999，156，： | 1 |
| 19 | Antipsychotic-Induced Weight Gain,A Coprehensive Research Synthesis显示文摘 | Allison DB Mentore JM Heo M | 1999 | Am J Psychiatry1999，156，： | 1 |
| 20 | Antipsychotic induced weight gain: comprehensive research synthesis显示文摘 | Allison DB Mentore JL Heo M | 1999 | AM J Psychiatry1999，156，11： | 1 |
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