|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris M C Chaloin L Mery J | 1999 | Nucleic Acids Res1999，27，17： | 1 |
| 3 | Isoelectric focusing a- nalysis of peroxidases in flax seedling hypocotyls grow in diffe- rent light conditions显示文摘 | BUREL C BERTHE T MERY J C | 1994 | Plant Physiology Biochemistry1994，32，： | 1 |
| 4 | Relationship between a his- tory of antecedent cancer and the probability of malignancy for a sol- itary pulmonary nodule显示文摘 | Mery C M Pappas A N Bueno R | 2004 | Chest2004，125，6： | 1 |
| 5 | A peptide carrier for the delivery of biologically active proteins into mammalian cells 显示文摘 | Morris M C Depollier J Mery J Heitz F Divita G | 2001 | Nat Biotechnol2001，19，： | 1 |
| 6 | Indexes of severity for osteoarthritis of the hip and knee显示文摘 | Leauesne M G Mery C | 1987 | Scand J Rheumatol Suppl1987，65，： | 1 |
| 7 | Fine-tuning in Ca^2+ homeostasis underlies progression of cardiomyopathy in myocytes derived from genetically modifled embryonic stem cells显示文摘 | Grey C Mery A Puceat M | 2005 | Hum Mol Genet2005，14，10： | 1 |
| 8 | Timing and magnitude of re- gional right ventricular function: a speckle tracking derived strain study of normal subjects and patients with right ventricular dys- function显示文摘 | Meris A Faletra F Conca C | 2010 | J Am Sec Echecardiogr2010，23，8： | 1 |
| 9 | Similar longterm survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance,epidemiology and end-results database显示文摘 | Mery C M Pappas A N Bueno R | 2005 | Chest2005，128，1： | 1 |
| 10 | Early histologic changes following polymethylmethacrylate injection(vertebroplasty) in rabbit lumbar vertebrae显示文摘 | Urrutia J Bono C M Mery P | 2008 | Spine2008，33，8： | 1 |
| 11 | A peptide carrier for thedelivery of biologically active proteins into mammalian cells显示文摘 | Morris M C Depollier J Mery J | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 12 | Comparison between theWOMAC and the Lequesne indices in patients with knee and hip os - teoarthritis显示文摘 | Lequesne MG Mery C Samson M | 1998 | Osteoarthritis Cartilage1998，6，6： | 1 |
| 13 | Dietary rice bran decreases plasma and whole-blood taurine in cats显示文摘 | Meri S P Robert C B Quinton R R | 2002 | J Nutr2002，132，： | 1 |
| 14 | Similar long-term survival of elderly patients with non-small cell lung cancer treated with Iobectomy or wedge resection within the surveillance, epidemiol- ogy, and end results database显示文摘 | Mery C M Pappas A N Bueno R | 2005 | CHEST Journal2005，128，1： | 1 |
| 15 | Timing and mag nitude of regional right ventricular function: a speckle trac- king derived strain study of normal subjects and patients with right ventricular dysfunction显示文摘 | MERIS A FALETRA F CONCA C | 2010 | Journal of the American So- ciety of Echocardiography: Official Publication of the Ameri- can Society of Echocardiography2010，23，8： | 1 |
| 16 | Overview of in-situ applicable nitrate removal processes显示文摘 | ROCCA C D BELGIORNO V MERI S | 2007 | Desalination2007，204，： | 1 |
| 17 | Maintenance of a physically active lifestyle after pulmonary rehabilitation in patients with COPD:a qualitative study toward motivational factors显示文摘 | Stewart KFJ Meris JJM Van de Bool C | 2014 | J Am Med Dir Assoc2014，15，9： | 1 |
| 18 | A peptide carrier for the delivery of biologically active proteins into mammalian cells 显示文摘 | MORRIS M C DEPOLLIER J MERY J | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 19 | A peptide carrier for the delivery of biologically active proteins into mammalian cells 显示文摘 | Morris M C Depollier J Mery J | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 20 | Indexes of Severity for Osteoarthritis of the Hip and Knee: Validation-Value in Compari- son with Other Assessment Tests显示文摘 | Lequesne MG Mery C Samson M | 1987 | Scand J Rheumatol1987，65，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员