|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Formation ages and source regions of the Palaeoproterozoic Gaofan, Hutuo and Dongjiao groups in the Wutai and Dongjiao areas of the North China Craton from SHRIMP U-Pb dating of detrital zircons: Resolution of debates over their stratigraphic relationships显示文摘这份报纸在北方中国 Craton 的 Wutai 和 Dongjiao 区域报导 Gaofan, Hutuo 和 Dongjiao 组的元沉积的岩石的由岩屑形成的锆石年龄分布。由岩屑形成的锆石一从 Gaofan 组的 quartzite 主要是在年龄的 2.5 Ga,与大约 2.7 Ga 并且更旧。A 石英岩从 Hutuo 组的基础集团企业的卵石在到 Gaofan 组的 quartzite 的由岩屑形成的锆石年龄分发是类似的。为从 Dongjiao 组的 meta-feldspar-quartz 沙岩,由岩屑形成的锆石的年龄主要在 2.5 Ga 被集中。比 2.6 Ga 旧的锆石都没被识别,但是在年龄与一些是 1.84 Ga 和 2.22.0 Ga。与更早的研究结合了,下列结论能被得出:(1 ) Gaofan 组是在年龄的早 Palaeoproterozoic 并且对迟了的 Neoarchaean Wutai 花岗石绿岩岩层年轻得多、无关,它 unconformably 躺它。因此, Gaofan 组是在诺思中国 Craton 的最旧的 Palaeoproterozoic 元沉积的单位之一。(2 ) Hutuo 组在一个大陆人地下室上在中间的 Palaeoproterozoic (2.14-2.09 Ga ) 被扔,在早 Palaeoproterozoic Gaofan 组后面。(3 ) Dongjiao 组在 1.84 Ga 以后被形成,并且可能属于 Changcheng 系统的更低的部分。(4 ) 从所有三个组的由岩屑形成的锆石显示出 2.5 Ga 的一座明显的年龄山峰,从在北方中国 Craton 在太古代的结束在强烈 tectono-magma-thermal 事件形成的火的岩石被采购。 | WAN YuSheng MIAO PeiSheng LIU DunYi YANG ChongHui WANG Wei WANG HuiChu WANG ZheJiu DONG ChunYan DU LiLin ZHOU HongYing | 2010 | Chinese Science Bulletin2010，55，13： | 32 |
| 2 | Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia显示文摘脉管的光滑的肌肉房间(VSMC ) 的增加的增长和移植是在动脉粥样硬化患者损害的开发的关键事件。Baicalin,导出植物的 flavonoid 混合物,以前被显示了通过多重小径在癌症房间导致 apoptosis 和生长抑制。然而,在 VSMC 增长和心血管的疾病的预防的规定的 baicalin 的潜在的角色仍然保持未经勘探。在这研究,我们证明有 baicalin 的那个预告的处理有一个剂量依赖者 PDGF-BB-stimulated VSMC 增长上的禁止的效果,与增殖的减小伴随了房间原子抗原(PCNA ) 表示。我们也证明导致 baicalin 的生长抑制在在 p27 的激活和增加在刺激 PDGF 的 VSMC 铺平的 cyclin E-CDK2 与减少被联系,它看起来是部分至少由 PDGF 受体尾的封锁调停了(PDGFR 尾) 发信号的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 。另外, baicalin 也被发现禁止 PDGF-BB 在 VSMC 导致的粘附分子表达式和房间移植。而且,使用一根动物颈动脉动脉的汽球损害模型,我们发现 baicalin 显著地禁止了 neointimal 增生。一起拿,我们的结果在导致生长揭示 baicalin 的新奇功能在汽球损害以后刺激 PDGF 的 VSMC 和压制的 neointimal 增生逮捕,并且建议内在的机制经由 PDGFR 尾 - 的封锁包含在 p27 累积的 cyclin E-CDK2 激活和增加的抑制 ERK1/2 发信号串联。 | Li-Hua Dong Jin-Kun Wen Sui-Bing Miao Zhenhua Jia Hai-Juan Hu Rong-Hua Sun Yiling Wu Mei Han | 2010 | Cell Research2010，20，11： | 30 |
| 3 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 4 | CD44v6 in peripheral blood and bone marrow of patients with gastric cancer as micro-metastasis显示文摘瞄准:为了检测 CD44 的表示,与能力相关在有胃的癌症并且到的病人的外部血和骨髓微转移推出它的临床的意义。方法:从有胃的癌症和 6 控制的 46 个病人的外科手术前的外部血和骨髓标本被 CD44v6mRNA 的半量的 RT-PCR 扩大学习。从有胃的癌症和 14 控制的 40 个病人的外科手术前、手术后的外部血标本被 CD44v6mRNA 的量的 RT-PCR 扩大在相应经期学习。结果:半量的 RT-PCR 扩大证明外部血和骨髓的那 CD44v6mRNA 表情在 39 是积极的(84.8%) 并且 40 (86.9%) 有胃的癌症的 46 个病人分别地。在外部血, CD44v6mRNA 表示为 diffuse 是积极的 32 个病人并且为 14 个病人的在 9 的肠的类型(64.3%) 的在 30 的类型(93.8%) 。在另一方面在骨髓, CD44v6mRNA 表示为 diffuse 是积极的 32 个病人并且为 14 个病人的在 10 的肠的类型(71.4%) 的在 31 的类型(96.9%) 。在弥漫的类型和肠的类型之间有有效差量。量的 RT-PCR 扩大证明 CD44v6mRNA 没在控制的外部血被表示, CD44v6mRNA 表示为在有胃的癌症的 40 个病人的外科手术前的外部血是积极的,从 4.9 x 10 的表示层次(8 )- 3.2 x 10 (11 ) copies/g RNA。在外部血的 CD44v6mRNA 的平均表示水平是 3.9 x 10 (10 ) copies/g RNA。在在在到 7.6 x 10 的从 5.5 x 10 增加的药品操作(6 )(9 ) 以后的胃的癌症病人的外部血的 CD44v6mRNA 的表示层次 copies/g RNA 和平均水平是 2.4 x 10 (8 ) copies/g RNA (图 3B )(P = 0.00496 ) 。在药品操作以后,表示水平显著地减少了。结论:为 CD44v6mRNA 的半量、量的 RT-PCR 扩大是为察觉的一个敏感、特定的方法在外部血和骨髓微转移,它可能被用作肿瘤负担和治疗学的效果的指示物。 | Dao-Rong Wang Guo-Yu Chen Xun-Liang Liu Yi Miao Jian-Guo Xia Lin-Hai Zhu Dong Tang | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 5 | Effect and Safety of Guanxinning Tablet(冠心宁片) for Stable Angina Pectoris Patients with Xin(Heart)-Blood Stagnation Syndrome:A Randomized,Multicenter,Placebo-Controlled Trial显示文摘Objective: To investigate the effect and safety of Guanxinning Tablet(冠心宁片, GXN) for the treatment of stable angina pectoris patients with Xin(Heart)-blood stagnation syndrome(XBSS). Methods: One hundred and sixty stable angina pectoris patients with XBSS were randomly assigned to receive GXN(80 cases) or placebo(80 cases, Guanxinning simulation tablets, mainly composed of lactose), 4 tablets(0.38 g/tablet), thrice daily for 12 weeks. After treatment, an exercise stress test(treadmill protocol), Chinese medicine(CM) syndrome score, electrocardiogram(ECG), and nitroglycerin withdrawal rate were evaluated and compared in the patients between the two groups. Meanwhile, adverse events(AEs) were evaluated during the whole clinical trial. Results: Compared with the control group, the time extension of exercise duration in the GXN group increased 29.28±17.67 s after treatment(P>0.05);moreover, the change of exercise duration in the GXN group increased 63.10±96.96 s in subgroup analysis(P<0.05). The effective rates of angina pectoris, CM syndrome and ECG as well as nitroglycerin withdrawal rate were 81.33%, 90.67%, 45.76%, and 70.73%, respectively in the GXN group, which were all significantly higher than those in the control group(40.58%, 75.36%, 26.92%, 28.21%, respectively, P<0.05). Conclusion: GXN was a safe and effective treatment for stable angina pectoris patients with XBSS at a dose of 4 tablets, thrice daily. | SUN Ming-yue MIAO Yang JIN Min DONG Yao-rong LIU Shu-rong WANG Mu-lan GAO Rui | 2019 | Chinese Journal of Integrative Medicine2019，25，9： | 22 |
| 6 | Tilted Fiber Bragg Gratings:Principle and Sensing Applications显示文摘In this paper,the mode coupling mechanism of tilted fiber Bragg gratings(TFBGs)is briefly introduced at first.And a general review on the fabrication,theoretical and experimental research development of TFBGs is presented from a worldwide perspective,followed by an introduction of our current research work on TFBGs at the Institute of Modern Optics,Nankai University(IMONK),including TFBG sensors for single-parameter measurements,temperature cross sensitivity of TFBG sensors,and TFBG-based interrogation technique.Finally,we would make a summary of the related key techniques and a remark on prospects of the research and applications of TFBGs. | Xiaoyi DONG Hao ZHANG Bo LIU Yinping MIAO | 2011 | Photonic Sensors2011，1，1： | 15 |
| 7 | Synthesis and characterization of Sb-doped SnO_2-(CeO_2-TiO_2) composite thin films deposited on glass substrates for antistatic electricity and UV-shielding显示文摘Sb-doped SnO2(ATO)-(CeO2-TiO2) thin Films were deposited on glass substrates using the mixed solution including CeO2-TiO2 precursor and ATO particles by sol-gel dip coating process.ATO particles were prepared using low-temperature hydrothermal process.The mixed molar ratio of ATO to(CeO2-TiO2) vs the properties of CeO2-TiO2 thin film was investigated.The optical properties of the films were characterized by UV-visible transmission and infrared reflection spectra,the sheet resistance of ATO particles and films were measured by rubber sheeter(MYI-50) and four-point probe(HisuperGroup Inc,SDY-5),the surface morphology and structure of the films were analyzed using 3D Digitale Mikroskop and X-ray diffraction(XRD),respectively.The results showed that the ATO precursor solution lost weight completely at about 500 oC,and the ATO particles was obtained,which indicated the same rutile lattice structure as SnO2.The glass substrates coated with ATO-(CeO2-TiO2) thin films showed better properties in antistatic electricity(104-106 Ω/),shielding UV(almost 100%),visible light transmission(70%) and infrared reflection(>30%). | WU Shuo1,ZHAO Qingnan1,MIAO Dengkui1,DONG Yuhong2(1.Key Laboratory for Silicate Materials Science and Engineering of Ministry of Education,Wuhan University of Technology,Wuhan 430070,China 2.Jiangsu Xiuqiang Glasswork CO.,Ltd.,Suqian 223800,China) | 2010 | Journal of Rare Earths2010，28，S1： | 14 |
| 8 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
| 9 | A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo显示文摘 | Chao Jiang Miao Mei Bin Li Xiurui Zhu Wenhong Zu Yujie Tian Qiannan Wang Yong GUO Yizhou Dong Xu Tan | 2017 | Cell Research2017，27，3： | 12 |
| 10 | Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model显示文摘选择是最可能的发展的卵母细胞是关键的为在 vitrofertilization 并且动物克隆。染色的灿烂的 cresyl 蓝色(BCB ) 在大型家畜被用于卵母细胞选举,但是它的更宽的用途需要推进评估。我们再划分进染色的那些(BCB+) 和那些的老鼠卵母细胞未沾污(BCB-) 根据他们的 ooplasm BCBcoloration。染色质配置,积云房间 apoptosis,细胞质的成熟和发展胜任在 BCB+ 和 BCB- 卵母细胞之间被比较。BCB+ 卵母细胞的胜任上的卵母细胞直径,性成熟和 gonadotropin 刺激的效果也被分析。在thelarge尺寸和中等尺寸的组,BCB+卵母细胞更大并且显示出更多的包围 nucleoli ( SN )染色质配置和早闭锁的更高的频率,并且他们也获得了更好细胞质的成熟(象细胞内部的 GSH 水平和 mitochondrialdistribution 的模式坚定)并且在试管内成熟( IVM )以后的更高发展的潜力比BCB卵母细胞。当没与 PMSG 告知时,成年老鼠比 prepubertal 老鼠与更高的胜任生产了更多的 BCB+ 卵母细胞。PMSG priming 增加了比例和 BCB+oocytes 的发展力量。在大尺寸的组的 BCB+ 卵母细胞在 medium-sizegroup 比他们的对应物显示出更多的 SN 染色质配置,更好细胞质的成熟和更高发展的潜力。染色的 BCB 能为卵母细胞选择被用作一个有效方法,这被结束,但是 BCB+ 卵母细胞的胜任可以与卵母细胞直径,动物性成熟和 gonadotropin 刺激变化。总起来说,这里描述的标准的系列将更好允许在为更好的开发选择卵母细胞的选择。 | Yan-Guang Wu Yong Liu Ping Zhou Guo-Cheng Lan Dong Han De-Qiang Miao Jing-He Tan | 2007 | Cell Research2007，17，8： | 11 |
| 11 | Reviews on Transformer Oil-based Nanofluids显示文摘目前纳米改性变压器油由于其高散热性和独特的电气性能,正受到越来越广泛的关注。以近年来纳米改性变压器油的相关研究成果为基础,分析了纳米改性变压器油在导热、击穿、老化、抗水分影响以及改性油-纸相互作用等方面的特点,并介绍了目前常用的3种用于解释绝缘油介质中纳米颗粒改性机理的理论模型,最后提出了纳米改性变压器油领域后续研究需要关注的问题,即纳米颗粒材料体系的选择、高稳定性改性变压器油的制备工艺以及纳米颗粒对变压器油的改性机理。 | Miao Jin Dong Ming Wu Xuezhou Shen Liangping Wang Hao | 2013 | 中国电机工程学报2013，33，9： | 11 |
| 12 | Prevalence and Genotypes of Rotavirus A and Human Adenovirus among Hospitalized Children with Acute Gastroenteritis in Fujian, China, 2009-2017显示文摘Gastroenteritis is an infectious diarrhea that has been considered as an important cause of hospitalizations and death in children aged < 5 years, particularly in developing countries. Unsanitary water, contaminated food, poor hygiene, and inadequate disposal of waste and feces are all risk factors for gastroenteritis, resulting in the higher incidence in developing countries. Gastroenteritis is generally caused by viral infections, among which rotavirus (RV) infections have been reported to be the most common, especially among young children aged < 5 years with acute gastroenteritis in Asia and Africa[1]. Other viruses associated with acute gastroenteritis include human Adenovirus (HAdV), Norovirus, Sapovirus (SaV), human Astrovirus (HAstV), and Aichi virus. Recent research has reported that adenovirus types 40 and 41, belonging to species F, cause gastroenteritis and were therefore termed as enteric adenoviruses. In addition, non-enteric HAdV species such as A, B, C, and D have been associated with diarrheal. | WU Bing Shan HUANG Zhi Miao WENG Yu Wei CHEN Feng Qin ZHANG Yun Lin LIN Wei Dong YU Ting Ting | 2019 | Biomedical and Environmental Sciences2019，32，3： | 10 |
| 13 | Prognostic significance of neutrophil to lymphocyte ratio in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization显示文摘 | Xu Xinsen Chen Wei Zhang Lingqiang Miao Runchen Zhou Yanyan Wan Yong Dong Yafeng Liu Chang | 2014 | Chinese Medical Journal2014，，24： | 10 |
| 14 | Architecture design for reliable and reconfigurable FPGA-based GNC computer for deep space exploration显示文摘SRAM(static random access memory)-based FPGA(field programmable gate array), owing to its large capacity, high performance, and dynamical reconfiguration, has become an attractive platform for So PC(system on programmable chip) development. However, as the configuration memory and logic memory of the SRAM-based FPGA are highly susceptible to SEUs(single-event upsets) in deep space, it is a challenge to design and implement a highly reliable FPGA-based system for spacecraft, and no practical architecture has been proposed. In this paper, a new architecture for a reliable and reconfigurable FPGAbased computer in a highly critical GNC(guidance navigation and control) system is proposed. To mitigate the effect of an SEU on the system, multi-layer reconfiguration and multi-layer TMR(triple module redundancy) techniques are proposed, with a reliable reconfigurable real-time operating system(Space OS) managing the system level fault tolerance of the computer in the architecture. The proposed architecture for the reconfigurable FPGA-based computer has been implemented with COTS(commercial off the shelf) FPGA and has firstly been applied to the GNC system of a circumlunar return and reentry flight vehicle. The in-orbit results show that the proposed architecture is capable of meeting the requirements of high reliability and high availability, and can provide the expressive varying functionality and runtime flexibility for an FPGA-based GNC computer in deep space. | YANG MengFei LIU Bo GONG Jian LIU HongJin HU HongKai DONG YangYang SHI Lei ZHAO YunFu MIAO ZhiFu | 2016 | Science China(Technological Sciences)2016，59，2： | 10 |
| 15 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress显示文摘Objective Anesthetic isoflurane plus surgery has been reported to induce cognitive impairment. The underlying mechanism and targeted intervention remain largely to be determined. Ginsenoside Rb1 was reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rb1 can attenuate isoflurane/surgery-induced cognitive dysfunction via inhibiting neuroinflammation and oxidative stress. Methods Five-months-old C57BL/6J female mice were treated with 1.4% isoflurane plus abdominal surgery for two hours. Sixty mg/kg ginsenoside Rb1 were given intraperitoneally from 7 days before surgery. Cognition of the mice were assessed by Barnes Maze. Levels of postsynaptic density-95 and synaptophysin in mice hippocampus were measured by Western blot. Levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in mice hippocampus were measured by ELISA. Results Here we show for the first time that the ginsenoside Rb1 treatment attenuated the isoflurane/surgery-induced cognitive impairment. Moreover, ginsenoside Rb1 attenuated the isoflurane/surgery-induced synapse dysfunction. Finally, ginsenoside Rb1 mitigated the isoflurane/surgery-induced elevation levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in the mice hippocampus. Conclusion These results suggest that ginsenoside Rb1 may attenuate the isoflurane/surgery-induced cognitive impairment by inhibiting neuroinflammation and oxidative stress pending future studies. | MIAO Hui Hui ZHANG Ye DING Guan Nan HONG Fang Xiao DONG Peng TIAN Ming | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 16 | Nia1 and Nia2 are Involved in Exogenous Salicylic Acid-induced Nitric Oxide Generation and Stomatal Closure in Arabidopsis显示文摘Phytohormone salicylic acid (SA) plays important roles in plant responses to environmental stress. However, knowledge about the molecular mechanisms for SA affecting the stomatal movements is limited. In this paper, we demonstrated that exogenous SA significantly induced stomatal closure and nitric oxide (NO) generation in Arabidopsis guard cells based on genetic and physiological data. These effects were significantly inhibited by the NO scavenger c-PTIO, NO synthase (NOS) inhibitor L-NAME or nitrate reductase suppressor tungstate respectively, implying that NOS and nitrate reductase (NR) participate in SA-evoked stomatal closing. Furthermore, the effects of SA promotion of stomatal closure and NO synthesis are significantly suppressed in NR single mutants of nia1, nia2 or double mutant nia1/nia2, compared with the wild type plants. This suggests that both Nia1 and Nia2 are involved in SA-stimulated stomatal closure. In addition, pharmacological experiments showed that protein kinases, cGMP and cADPR are involved in SA-mediated NO accumulation and stomatal closure induced by SA in Arabidopsis. | Fushun Hao Shiling Zhao Huan Dong Huan Zhang Lirong Sun Chen Miao | 2010 | Journal of Integrative Plant Biology2010，52，3： | 8 |
| 17 | Application of quantification theory in risk assessment of mine flooding显示文摘Hundreds of mine flooding accidents have occurred in China since the 1950s. These flooding accidents result in submerged working faces, even entire coal mines, leading to tremendous economic losses. It is reported that among 601 state-owned mines in China, 285 mines are exposed to water-inrush risks. The water pressure is becoming larger and larger with the increase of mining depth, leading to an increase of water-inrush hazards. Only when the risk of mine flooding is predicted in a reasonable manner, can we take timely and effective measures to prevent mine flooding from taking place. In our investigation quantifica- tion(II) theory is used to study the risk prediction problem about mine flooding. By investigating the main factors which affect mine flooding, eight risk assessment items have been identified. The extent of risk is classified into 4 grades. Given the data from different periods in the Feicheng mining area, a prediction model for the risk of mine flooding is established. The test analysis indicates a model correlation coefficient of 0.97 and the incidence of discrimination is as high as 97.37%, which implies that the effect of the model is quite satisfactory. With the help of computers, this method can be widely applied. | WANG Lian-guo MIAO Xie-xing DONG Xu WU Yu | 2008 | Journal of China University of Mining and Technology2008，18，1： | 8 |
| 18 | Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis显示文摘AIM: To determine the prognostic value of alkaline phosphatase(ALP) and γ-glutamyltransferase(GGT) for hepatocellular carcinoma(HCC).METHODS: We analyzed the outcome of 172 HCC patients who underwent liver resection. Receiver operating characteristic(ROC) curve analysis was performed to determine the cut-off value of ALP and GGT. Then, preoperative risk factors for survival were evaluated by multivariate analysis. Based on the significant factors, aprognostic score model was established.RESULTS: By ROC curve analysis, ALP > 120 U/L and GGT > 115 U/L were considered elevated. Overall survival(OS) and tumor-free survival(TFS) for patients with elevated ALP and GGT were significantly worse than for patients with ALP and GGT within the normal range. Multivariate analysis showed that the elevated levels of ALP, GGT and tumor size were independent prognostic factors. Giving each positive factor as a score of 1, we established a preoperative prognostic score model. The 5-year OS for patients with a score of 0, 1, 2 and 3 were 84.0%, 45.9%, 44.1% and 0%, respectively, while the TFS was 80.6%, 40.0%, 38.8% and 0%, respectively. When combining patients with scores of 1 and 2 into the middle risk group, and patients with scores of 0 and 3 into the low-risk and highrisk groups, respectively, different outcomes would be significantly distinguished by the risk groups.CONCLUSION: Elevated ALP and GGT levels were risk predictors in HCC patients. Our prognostic model might vary the outcomes of patients from different risk groups. | Xin-Sen Xu Yong Wan Si-Dong Song Wei Chen Run-Chen Miao Yan-Yan Zhou Ling-Qiang Zhang Kai Qu Si-Nan Liu Yue-Lang Zhang Ya-Feng Dong Chang Liu | 2014 | World Journal of Gastroenterology2014，20，31： | 8 |
| 19 | Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period显示文摘Background:Early pregnancy failure has a profound impact on both human reproductive health and animal production.2/3 pregnancy failures occur during the peri-implantation period;however,the underlying mechanism(s)remains unclear.Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy.Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.Result:In this study,using well-managed recipient ewes that received embryo transfer as model,we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period.After embryo transfer,recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy.By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes,we identified 94 and 257 differentially expressed proteins(DEPs) in the endometrial caruncular and intercaruncular areas,respectively.Functional analysis showed that the DEPs were mainly associated with immune response,nutrient transport and utilization,as well as proteasome-mediated proteolysis.Conclusion:These analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss.In addition,many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes.These proteins,as potential candidates,may contribute to early pregnancy loss. | Haichao Zhao Linlin Sui Kai Miao Lei An Dong Wang Zhuocheng Hou Rui Wang Min Guo Zhilong Wang Jiqiang Xu Zhonghong Wu Jianhui Tian | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 8 |
| 20 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员