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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 3 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 4 | Antiestrogenic properties of raloxifene显示文摘 | Michael W D David E F Julie A N | 1995 | Parmacology1995，50，： | 1 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Gold nanoparticle imaging and radiotherapy of brain tumors in mice显示文摘 | James F Hainfeld Henry M Smilowitz Michael J O&rsquor Connor Farrokh Avraham Dilmanian Daniel N Slatkin | 2013 | Nanomedicine2013，，10： | 1 |
| 7 | Carbon-cycle imbalances in the Sargasso Sea显示文摘 | Michaels A F Bates N R Buesseler K O | 1994 | Nature1994，372，： | 1 |
| 8 | Increase glutathione hiosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaecumulas显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 9 | Seasonal dynamics of colored dissolved material in the Sargasso Sea显示文摘 | NELSON N B SIEGEL D A MICHAELS A F | 1998 | Deep-Sea Re- search1998，45，： | 1 |
| 10 | Target costing operationalization during product development:Model and application显示文摘 | Tiago P F Francisco J K N Michael R D | 2009 | Int J Production Economics2009，，118： | 1 |
| 11 | Seasonal dynamics of colored dissolved organic material in the Sargasso Sea显示文摘 | Nelson N B Siegel D A Michaels A F | 1998 | Deep-Sea Res Pt I1998，45，： | 1 |
| 12 | An eestimate of the suspended particulate matter(SPM) transport in the southern North Sea using SeaWiFS images, in situ measurements and numerical model results 显示文摘 | Michael F Bouchra N Dries V E | 2007 | Conti- nental Shelf Research2007，27，： | 1 |
| 13 | A power system stabilizer for DFIG-based wind generation 显示文摘 | MICHAEL H F ANAYA-LARA O JENKINS N | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 14 | The Aerodynamics of free- flight maneuvers in drosophila 显示文摘 | Steven N F Rosalyn S Michael H D | 2003 | Science2003，300，： | 1 |
| 15 | Optimized ef? ciency and angular emission characteristics of white topemitting organic electroluminescent diodes显示文摘 | Michael T Robert N Mauro F el al | 2009 | Appl Phys Lett2009，94，08： | 1 |
| 16 | Body mass index and risk of ovarian cancer显示文摘 | Michael F Corinna K Kim N | 2009 | Cancer2009，115，4： | 1 |
| 17 | Increased glutathione biosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaccumulators显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 18 | The Lateral Diffusion of Lipid Probes in the Surface Membrane of Schistosoma mansoni 显示文摘 | Michael F Andrew N Mac Gregor | 1986 | J Cell Biology1986，103，： | 1 |
| 19 | Reducing leaching of borowbased wood preservatives-A review of research 显示文摘 | Diana N Obanda Todd F Shupe H Michael Barnes | 2008 | Bioresource technology2008，99，15： | 1 |
| 20 | Macro thyrotropin-IgG, complex causes factitious increase in thyroid-stimulating hormone screening tests in a neonate and mother(letter) 显示文摘 | David J H Michael N F Hall S K | 2006 | Clin Chem2006，52，10： | 1 |
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