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228篇 您的检索式：作者名="Michell J H"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘	Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel	2012	Cancer Causes & Control2012，，8：	2
3	Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘	Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran	2012	Lancet Neurology2012，，2：	2
4	Reducing probability of decision error using stochastic resonance 显示文摘	S kay J Michels H Chen P Varshney	2006	IEEE Signal Processing letter2006，13，11：	1
5	Safety of telmisartan in patients with arterial hypertension: an own-label observational study 显示文摘	Michel MC Bohner H Koster J	2004	Drug Saf2004，27，5：	1
6	Effect of surfactant addition on phenanthrene biodegradation in sediments显示文摘	Harry J T Joseph B H Michelle T J	1995	Environ Toxicol Chem1995，14，6：	1
7	Safety of telmisartan in patients with arterial hypertension:an open-label observational study显示文摘	MICHEL MC BOHNER H K(O)STER J	2004	Drug Saf2004，27，5：	1
8	A pro-drug of thegreen tea polyphenol(-)-epigallocatechin-3-gallate(EGCG)ester deriv-atives:Effect of alkyl chain length显示文摘	CHAO J F LAU WAY KWOK-WAI MICHELLE J H	2008	Bioorganic&Medicine ChemistryLetters2008，18，14：	1
9	Individual singlewall carbon nanotubes as quantum wires显示文摘	Tans S J Michel H D Dai Hongjie	1997	Nature1997，386，6624：	1
10	A versatile route to functionalized dilactones as monomers for the synthesis of poly (α-hydroxy)acids显示文摘	Leemhuis M van Steenis Jan H van Uxem Michelle J	2003	European Journal of Organic Chemistry2003，2003，：	1
11	Adaptive CFAR detection for clutter-edge heterogeneity using Bayesian inference 显示文摘	Biao C Varshney P K and Michels J H	2003	IEEE Transactions on Aerospace and Electronic Systems2003，39，4：	1
12	CD137 induces proliferation and endomitosis in monocytes显示文摘	Langstein J Michel J Schwarz H	1999	Blood1999，94，：	1
13	Lower cardiac troponin T levels in patients undergoing cardiopulmonary bypass and receiving high-dose aprotinin therapy indicate reduction of perioperative myocardial damage显示文摘	Michel J Heller W Wendel H P	1995	J Thorac Cardiovasc Surg1995，109，6：	1
14	The crystral structure of the light-harvesting II (B800-850) from Rhodospirillum molischianum 显示文摘	Koepke J Hu X Munke C Schulten K Michel H	1989	Structure1989，4，：	1
15	Oxiliplatin combined to 5-FU and folinic acid (5-FU/FA) as second-third-line treatment in patients with advanced colorectal cancer显示文摘	Greread B Bleiberg H Michel J	1997	Proc Ann Meet Am Soc Clin Oncol1997，16，：	1
16	Decomposition of laser altimeter waveforms 显示文摘	Michelle A H Jean B M Bryan J	2000	IEEE Transaction on Geoseienee and Remote Sensing2000，38，4：	1
17	显示文摘	Michel J Schwarz H	2002	Cytokine2002，12，6：	1
18	Growth and characterization of InAs/GaSb photoconductors for long wavelength infrared range 显示文摘	MOHSENI H MICHEL E SANDOEN J	1997	Appl Phys Lett1997，71，10：	1
19	Inactivation of Influenza A Virus on Copper Versus Stainless Steel Surfaces显示文摘	Noyce J O Michels H Keevil C W	2007	App Environ Microbiol2007，73，8：	1
20	Root distribution of two tree species under a heterogeneous nutrient environment显示文摘	MOU P MICHELL R J JONES R H	1997	J Appl Ecol1997，34，：	1

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