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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 3 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 4 | Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity显示文摘 | Shinichi Takayama Takaaki Sato Stanislaw Krajewski Kristine Kochel Shinji Irie Juan A Milian John C Reed | 1995 | Cell1995，，2： | 2 |
| 5 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 6 | Psychological distress,depressive symptoms,and cellular immunity among healthy individuals:a 1-year prospective study显示文摘 | Nakata A Irie M Takahashi M | | 0，，03： | 1 |
| 7 | Uncertain analgetic efficacy of intraurethral instillation of anesthetic jelly in rigid cystoseopy for men显示文摘 | Matsuda D Irie A Shimura S | 2005 | Nippon Hinyokika Gakkai Zasshi2005，96，6： | 1 |
| 8 | Specific binding of glycyrrhetinic acid to the rat liver membrane显示文摘 | Negishi M Irie A Nagata N | 1991 | Biochim Biophys Acta1991，1066，1： | 1 |
| 9 | Preference toward a T-helper 1 response in patients with coronary spastic angina显示文摘 | Irie A Miyamoto S | 2003 | Circulation2003，107，： | 1 |
| 10 | Evaluation of genotoxic and antigenotoxic effects of hydroalcoholic extracts of Zuccagnia punctata Cav.显示文摘 | Iris Catiana Zampini Milena Villarini Massimo Moretti Luca Dominici María Inés Isla | 2007 | Journal of Ethnopharmacology2007，，2： | 1 |
| 11 | A pillow-shaped respiration monitor显示文摘 | Yamakose H Kuno H Nambu M Irie T Higuchi M Sahashi A Tamura T | 2001 | Life Support2001，，13： | 1 |
| 12 | Rational Design of Mn-salen Epoxidation Catalysts:Preliminary Results显示文摘 | Hosoya N Hatayama A Irie R | 1994 | Tetrahedron1994，50，15： | 1 |
| 13 | Endogenous fungal endophthalmitis:risk factors,clinical course,and visual outcome in 13 patients显示文摘AIM:To analyze the risk factors,ophthalmological features,treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis(EFE).METHODS:Data retrieved from the medical files included age at presentation to the uveitis clinic,gender,ocular symptoms and their duration before presentation,history of fever,eye affected,anatomical diagnosis and laboratory evidence of fungal infection.Medical therapy recorded included systemic antifungal therapy and its duration,use of intravitreal antifungal agents and use of oral/intravitreal steroids.Surgical procedures and the data of ophthalmologic examination at presentation and at last follow-up were also collected.RESULTS:Included were 13 patients(20 eyes,mean age 58 y).Ten patients presented after gastrointestinal or urological interventions and two presented after organ transplantation.In one patient,there was no history of previous intervention.Diagnostic vitrectomy was performed in 16 eyes(80%)and vitreous cultures were positive in 10 of the vitrectomized eyes(62.5%).In only 4 patients(31%),blood cultures were positive.All patients received systemic antifungal therapy.Sixteen eyes(80%)received intravitreal antifungal agent with voriconazole being the most commonly used.Visual acuity(VA)improved from 0.9±0.9 at initial exam to 0.5±0.8 logMAR at last followup(P=0.03).A trend of greater visual improvement was noted in favor of eyes treated with oral steroids(±intravitreal dexamethasone)than eyes that were not treated with steroids.The most common complication was maculopathy.Twelve eyes(60%)showed no ocular complications.CONCLUSION:High index of suspicion in patients with inciting risk factors is essential because of the low yield of blood cultures and the good general condition of patients at presentation.Visual prognosis is improved with the prompt institution of systemic and intravitreal pharmacotherapy and the immediate surgical intervention.Oral±local steroids could be considered in cases of prolonged or marked inflammatory responses in order to hasten control of inflammation and limit ocular complications. | Jamel Corredores Itzhak Hemo Tareq Jaouni Zohar Habot-Wilner Michal Kramer Shiri Shulman Haneen Jabaly-Habib Ala'a Al-Talbishi Michael Halpert Edward Averbukh Jaime Levy Iris Deitch-Harel Radgonde Amer | 2021 | International Journal of Ophthalmology(English edition)2021，14，1： | 1 |
| 14 | Simultaneous determination of thickness and optical constants of thin films显示文摘 | Forouhi A R Iris Bloomer | 1995 | SPIE1995，2439，： | 1 |
| 15 | TiO2 photocatalysis: a his- torical overview and future prospects显示文摘 | Hashimoto K Irie H Fujishima A | 2005 | Japanese Journal of Applied Physics2005，44，12： | 1 |
| 16 | 显示文摘 | Hashimoto K Irie H Fujishima A | 2005 | Appl Phys2005，44，12： | 1 |
| 17 | Preference toward a T-helper type 1 response in patients with coronary spastic angina显示文摘 | SOEJIMA H IRIE A MIYAMOTO S | 2003 | Circulation2003，107，： | 1 |
| 18 | Severe osteo-porosis in mice lacking osteoclastogenesis inhibitoryfactor/osteoprotegerin 显示文摘 | Mizuno A Amizuka N Irie K | 1998 | Biochem Biophys ResCommun1998，247，3： | 1 |
| 19 | p53 Mutation in bladder cancer patients in Japan and inhibition of growth by in vitro edanovirusmediated wild-type p53 transduction in bladder cancer cells显示文摘 | Uchida T Ishida H | 2001 | Mol Urol2001，5，2： | 1 |
| 20 | Synthesis and phorbol ester binding of the eysteinerich domains of diaeylglyeerol kinase (DGK) isozymes显示文摘 | Shindo M Irie K Masuda A | 2003 | J Bio Chem2003，278，18： | 1 |
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