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| 1 | β内酰胺类抗生素与对非典型病原体有效的抗生素在非重症社区获得性肺炎中的疗效比较:汇总分析显示文摘目的对于社区获得性肺炎,将β内酰胺类抗生素与对非典型病原体有效的抗生素进行全面系统的疗效比较。资料来源Medline、Embase、Cochrane登记注册的对照试验、国际性会议的会议纪录、药品注册机构以及制药公司。评价方法通过总结双盲、随机、对照、单一给药疗法试验,对β内酰胺类抗生素与对非典型病原体有效的抗生素在成人社区获得性肺炎的疗效方面进行比较。主要结局指标是未达到临床治愈或好转。结果18项临床试验共纳入6749例受试者,其中大多数患者有轻至中度社区获得性肺炎。对各种原因引起的社区获得性肺炎治疗失败的相对危险度进行分析,结果显示对非典型病原体有效的抗生素并不优于β内酰胺类抗生素(0.97,95%可信区间0.87~1.07)。对于有特异性非典型病原体感染诊断的患者进行亚组分析,我们发现应用对非典型病原体有效的抗生素治疗军团菌属感染的肺炎患者,其治疗无效率明显的低一些(0.40,0.19~0.85)。而在肺炎支原体(0.60,0.31~1.17)和肺炎衣原体(2.32,0.67~8.03)感染的肺炎患者中二者的疗效相似。结论应用对非典型病原体有效的抗生素治疗由各种原因引起的非重症社区获得性肺炎,而使临床疗效得到提高的证据是不足的。尽管此类抗生素在对稍后介绍的军团菌感染相关性肺炎的治疗方面显示出明显的优势,但已纳入研究范围内的肺炎病例很少是由这种病原体引起的。β内酰胺类制剂应该继续作为成人非重症社ResInfe区获得性肺炎治疗的首选抗生素。 | Graham D Mills Michael R Oehley Bruce Arrol 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 2 |
| 2 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 3 | Experimental investigation on cavity flows显示文摘 | Mills R D | 1965 | Jourmal of Radar and Aeronautics1965，69，： | 1 |
| 4 | Effects of Exposure to Objectified Male and Female Media Images on Men,s Psychological Well-Being显示文摘 | Johnson P J McCreary D R Mills J S | 2007 | Psychology of Men & Mascu- linity2007，8，2： | 1 |
| 5 | Theory of electron-avalanche breakdown in solid显示文摘 | Sparks M Mills D L Holstein R W T | 1981 | Phys Rev B1981，24，6： | 1 |
| 6 | Effect of polymerization on particle morphology in heterogeneous systems显示文摘 | MILLS M F GIBERT R G NAPPER D H | 1990 | Macromolecules1990，，23： | 1 |
| 7 | Elevated procalcitonin as a diagnostic marker in meningococcal disease显示文摘 | MILLS G D LALA H M OEHLEY M R | 2006 | Eur J Clin Micro- biol Infect Dis2006，25，： | 1 |
| 8 | Compact linear fresnel reflector solar thermal power plants显示文摘 | MILLS D R MORRISON G L | 2000 | Solar Energy2000，68，3： | 1 |
| 9 | Effectiveness of beta lactam antibiotics compared with antibiotics active against atypical pathogens in non-severe community acquired pneumonia:meta-analysis显示文摘 | Oehley M R Arrol B | 2005 | BMJ2005，330，： | 1 |
| 10 | Quantitative structure-activity relationship modeling of mosquito repellents using calculated descriptors 显示文摘 | NATATAJAN R BASAK S C MILLS D | 2008 | Croatica Chemica Acta2008，81，2： | 1 |
| 11 | Metabolic consequences of continent urinary diversion 显示文摘 | Mills R D Studer U E | 1999 | J Urol1999，161，4： | 1 |
| 12 | Midcourse space experiment: introduction to the spacecraft, instruments, and scientific objectives 显示文摘 | Mill J D O'Neil R R Price S | 1994 | Journal of Spacecraft and Rockets1994，31，5： | 1 |
| 13 | Cooling of photovoltaic cells under concentrated illumination: a critical review 显示文摘 | ROYNE A DEY C J MILLS D R | 2005 | Solar Energy Materials and Solar Cells2005，86，： | 1 |
| 14 | Water Purification by semiconductor photocatalysis 显示文摘 | MILLS A DAVID R H WORSLEY D | 1993 | Chem Soc Review1993，23，2： | 1 |
| 15 | Species specificity of social rein- statement in Japanese quail ( Coturnix japonica ) genetically selected for high of low levels of social reinstatement behaviour显示文摘 | Mills A D Jones R B Faure J M | 1995 | Behavioural Processes1995，34，： | 1 |
| 16 | Multichannel analysis of surface waves显示文摘 | Park C B Mille R D Xia J | 1999 | Geophysics1999，64，3： | 1 |
| 17 | Metabolic consequences of continent urinary diversion显示文摘 | MILLS R D STUDER U E | 1999 | J Urol1999，161，4： | 1 |
| 18 | Theory of electron-avalanche breakdown in solids显示文摘 | SPARKS M MILLS D L WARREN R | 1981 | Phys Rev B1981，24，6： | 1 |
| 19 | Relationship between Reproductive Success and Male Plasma Vitellogenin Concentrations in Cunner, Tautogolabrus adspersus显示文摘 | MILLS L J GUTJAHR-GOBELL R E HOROWITZ D B | 2003 | Environmental Health Perspective2003，111，1： | 1 |
| 20 | Spectral beam splitting technolo- gy for increased conversion efficiency in solar concentra- ting systems-A review 显示文摘 | Imenes A G Mills D R | 2004 | Solar Energy Materials & Solar Cells2004，84，14： | 1 |
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