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| 1 | Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas显示文摘Cutaneous malignant melanoma is the most aggressive form of skin cancer with an extremely poor survival rate for the patients diagnosed with locally invasive and metastatic disease states. Intensive research has led in last few years to an improvement of the early detection and curative treatment of primary cutaneous melanomas that are confined to the skin by tumor surgical resection. However, locally advanced and disseminated melanomas are generally resistant to conventional treatments, including ionizing radiation, systemic chemotherapy, immunotherapy and/or adjuvant stem cellbased therapies, and result in the death of patients. The rapid progression of primary melanomas to locally invasive and/or metastatic disease states remains a major obstacle for an early effective diagnosis and a curative therapeutic intervention for melanoma patients. Importantly, recent advances in the melanoma research have led to the identification of different gene products that are often implicated in the malignant transforma-tion of melanocytic cells into melanoma cells, including melanoma stem/progenitor cells, during melanoma initiation and progression to locally advanced and metastatic disease states. The frequent deregulated genes products encompass the oncogenic B-Raf V600 E and N-RasQ 61 R mutants, different receptor tyrosine kinases and developmental pathways such as epidermal growth factor receptor(EGFR), stem cell-like factor(SCF) receptor KIT, hedgehog, Wnt/β-catenin, Notch, stromal cell-derived factor-1(SDF-1)/CXC chemokine receptor-4(CXCR4) and vascular endothelial growth factor(VEGF)/VEGFR receptor. These growth factors can cooperate to activate distinct tumorigenic downstream signaling elements and epithelial-mesenchymal transition(EMT)-associated molecules, including phosphatidylinositol 3'-kinase(PI3K)/Akt/ molecular target of rapamycin(mT OR), nuclear factor-kappaB(NF-κB), macrophage inhibitory cytokine-1(MIC-1), vimentin, snail and twist. Of therapeutic relevance, these deregulated signal transduction components constitute new potential biomarkers and therapeutic targets of great clinical interest for improving the efficacy of current diagnostic and prognostic methods and management of patients diagnosed with locally advanced, metastatic and/or relapsed melanomas. | Murielle Mimeault Surinder K Batra | 2012 | World Journal of Clinical Oncology2012，3，3： | 5 |
| 2 | Recent advances in cancer stem/progenitor cell research:therapeutic implications for overcoming resistance to the most aggressive cancers 显示文摘 | Mimeault M Hauke R Mehta PP | 2007 | J Cell Mol Med2007，11，5： | 1 |
| 3 | Evaluation of insomnia: validity of 3 questionnaires显示文摘 | Blais FC Gendron L Mimeault V | 1997 | Encephale1997，23，6： | 1 |
| 4 | Successful smallbowel/liver transplantation显示文摘 | Grant D Wall W Mimeault R | 1990 | Lancet1990，335，2： | 1 |
| 5 | Recent progress on normal and malignant pancreatic stem/progenitor cell research:Therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer显示文摘 | MIMEAULT M BATRA SK | 2008 | Gut2008，57，： | 1 |
| 6 | Frequent deregulations in the hedge- hog signaling network and cross - talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies显示文摘 | MIMEAULT M BATRA S K | 2010 | Pharmacol Reviews2010，62，3： | 1 |
| 7 | Recent advances in cancer stem/progenitor cell research : therapeutic implications for overcoming resistance to the most aggressive cancers显示文摘 | M Mimeault R Hauke PP Mehta | 2007 | J Cell Mol Mad2007，11，5： | 1 |
| 8 | Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies 显示文摘 | Mimeault M Hauke R Batra SK | 2008 | Clin Pharmaeol Ther2008，83，5： | 1 |
| 9 | Recent insights into the molecular mechanisms involved in aging and the malignant transfor- mation of adult stem/progenitor eellg and their therapeu- tic implications显示文摘 | Mimeault M Batra SK | 2009 | Ageing Res Rev2009，8，2： | 1 |
| 10 | Divergent molecular mechanisms un- derlying the pleiotropic functions of macrophage inhibitory cy- tokine-1 in cancer显示文摘 | Mimeault M Batra SK | 2010 | J Cell Physiol2010，224，3： | 1 |
| 11 | Concise review:recent advances on the significance of stem cells in tissue regeneration and cancer therapies显示文摘 | MIMEAULT M BATRA S K | 2006 | Stem Cells2006，24，11： | 1 |
| 12 | Concise review:recent advances on the significance of stem cells in tissue regeneration and cancer therapies 显示文摘 | Mimeault M Batra SK | 2006 | Stem Cells2006，24，1： | 1 |
| 13 | Divergent molecular mechanismsunderlying the pleiotropic functions of macrophage inhibitory cyto-kine-1 in cancer显示文摘 | MIMEAULT M BATRA S K | 2010 | J Cell Physiol2010，224，3： | 1 |
| 14 | Recent advanc- es on the molecular mechanisms involved in the drug resis- tance of cancer cells and novel targeting therapies 显示文摘 | MIMEAULT M HAUKE R BATRA S K | 2008 | Clin Pharmacol Ther2008，83，： | 1 |
| 15 | Pathobiological implications of the expression of EGFR,pAkt,NF-κB and MIC-1 in prostate cancer stem cells and their progenies显示文摘 | Mimeault M Johansson SL Batra SK | 2012 | PLoS One2012，7，31： | 1 |
| 16 | Inhibition of hedgehog signaling improves the anti-carcinogenic effects of detaxel in pros- tate cancer 显示文摘 | Mimeault M Racimgani S Muniyan S | 2015 | Oncotarget2015，6，6： | 1 |
| 17 | Hypoxia-inducing factors as master reg-ulators of sternness properties and altered metabolism of cancer-and metastasis -initiating cells 显示文摘 | Mimeault M Surinder K | 2013 | J Cell Mol Med2013，17，1： | 1 |
| 18 | Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies显示文摘 | MIMEAULT M BATRA S K | 2006 | Stem Cells2006，24，11： | 1 |
| 19 | Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies显示文摘 | MIMEAULT M BATRA SK | 2006 | Carcinogenesis2006，27，： | 1 |
| 20 | Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancer 显示文摘 | Mimeault M Hauke R Mehta P P | 2007 | J Cell Mol Med2007，11，： | 1 |
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