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| 1 | Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B_1-induced hepatotumorigenesis in mice显示文摘瞄准:估计黄麴毒素的结合的角色 B1 (AFB1 ) , cyanobacterial 毒素(cyanotoxins ) ,和肝炎 B (HBV ) 在 hepatotumorigenicity 的 x 基因。方法:( ip )带 HBV x 基因和他们的野类型的同窝出生的人的 One-week-old 动物 intraperitoneally 与也被注射单个剂量的 AFB1 [ 6 mg/kg 体重( bw )],重复剂量 cyanotoxins ( microcystin-LR 或在榴状, 10 microg/kg bw 每周一次为 15 wk ), DMSO (车辆控制)独自一个,或 AFB1 一个星期以后由 cyanotoxins 列在后面,并且在 24 和 52 wk 被牺牲处理以后。结果:AFB1 在 29 中的 13 个导致了肝肿瘤(44.8%) 在 52 wk 的转基因的老鼠处理以后,显著地比在野类型的老鼠(13.3%) 更经常。这有效差量没在 24-wk 学习被显示出。与 AFB1 暴露相比独自一个, MC-LR 并且在榴状在导致的 AFB (1 ) 的发生产出近似 3 褶层和 6 褶层增加在在 24 wk 的野类型的动物的肝肿瘤分别地。HBV x 基因进一步没提高与合作暴露联系到 AFB1 和 cyanotoxins 的风险。与一个 MC-LR-dosed 野类型的鼠标的异常,没有肝肿瘤在在 24 wk 独自与 cyanotoxins 对待的鼠标被观察。既不对待 DMSO 的转基因的老鼠也不他们的野类型的同窝出生的人在甚至多达 52 wk 有与 hepatotumorigenesis 相关的病理学的改变。结论:HBV x 基因并且在榴状支持导致的 AFB (1 ) 的发展肝肿瘤。到 AFB1 和 MC-LR 的合作暴露趋于相对暴露在 24 wk 提高肝肿瘤的风险到他们之一。hepatotumorigenesis 上的 AFB1, cyanotoxins 和 HBVx 的结合的效果在 24 wk 是弱的。 | Min Lian Ying Liu Shun-Zhang Yu Geng-Sun Qian Shu-Guang Wan Kenneth R Dixon | 2006 | World Journal of Gastroenterology2006，12，19： | 14 |
| 2 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 3 | Subseasonal features of the Asian summer monsoon in the NCEP climate forecast system显示文摘The operational climate forecast system(CFS)of the US National Centers for Environmental Prediction provides climate predictions over the world,and CFS products are becoming an important source of information for regional climate predictions in many Asian countries where monsoon climate dominates.Recent studies have shown that,on monthly-to-seasonal time-scales,the CFS is highly skillful in simulating and predicting the variability of the Asian monsoon.The higher-frequency variability of the Asian summer monsoon in the CFS is analyzed,using output from a version with a spectral triangular truncation of 126 waves in horizontal and 64 sigma layers in vertical,focusing on synoptic,quasi-biweekly,and intraseasonal time-scales.The onset processes of different regional monsoon components were investigated within Asia.Although the CFS generally overestimates variability of monsoon on these time-scales,it successfully captures many major features of the variance patterns,especially for the synoptic time-scale.The CFS also captures the timing of summer monsoon onsets over India and the Indo-China Peninsula.However,it encounters difficulties in simulating the onset of the South China Sea monsoon.The success and failure of the CFS in simulating the onset of monsoon precipitation can also be seen from the associated features of simulated atmospheric circulation processes.Overall,the CFS is capable of simulating the synoptic-to-intraseasonal variability of the Asian summer monsoon with skills.As for seasonal-to-interannual time-scales shown previously,the model is expected to possess a potential for skillful predictions of the high-frequency variability of the Asian monsoon. | Song YANG WEN Min R Wayne HIGGINS | 2008 | Acta Oceanologica Sinica2008，27，3： | 3 |
| 4 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 5 | The Maturation and Senescence in Relation to Ca^2+,CaMContent and Ca^2+-ATPase Activity and Active OxygenMetabolism in Strawberry Fruits显示文摘The changes in content of Ca2 + and CaM, Ca2 + -ATPase activity and active oxygen metabolism during strawberry (Fragaria ananassa Duch. cv. Chunxing) fruits maturation and senescence were investigated in this study. The results showed that the soluble Ca2 + content and SOD activity in fruits tended to decline and O2.-production rate to increase, the Ca2+ -ATPase activity peaked at first and then declined during fruits maturation and senescence. There were the highest CaM content at white stage in preharvest fruits and at marked senescence stage in postharvest ones. The above biochemical changes in fruits stored at low temperature (4℃) were slower than those stored at normal temperature(25℃ ). Thus, it indicated that the stimulation of calcium messenger system and accumulation of active oxygen free radical were closely related to fruits maturation and senescence. | GUAN Jun-feng, GAO Min, FAN Xiu-cai, GU Cai-qin, LI Guang-min and ZHANG Ji-shu(Institute of Agro-Physics , Plant Physiology and Biochemistry , Hebei Academy of Agricultural and Forestry Sciences ,Shijiazhuang 050051 , P. R . China College of Life Sciences , Northwestern Science and Technology Universityof Agriculture and Forestry, Yangling 712100 , P.R.China) | 2002 | Agricultural Sciences in China2002，1，10： | 3 |
| 6 | Rare case of Helicobacter pylori-positive multiorgan Ig G4-related disease and gastric cancer显示文摘A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension,pruritus and jaundice.Laboratory testing revealed an elevated serum Ig G4 level.A computed tomography scan showed a typical feature of autoimmune pancreatitis(AIP) and cholecystocholangitis.Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration(EUSFNA) of the pancreas was carried out.The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy.Helicobacter pylori(H.pylori) and Ig G4-positive plasmacytes were detected in gastric cancer tissue,pancreatic EUSFNA sample and resected gallbladder specimen by immunohistochemistry.The patient was diagnosed with H.pylori-positive Ig G4-related AIP and sclerosing cholecystocholangitis as well as H.pylori-positive gastric cancer.He responded well to steroid therapy and remains healthy with no signs of recurrence at one year follow-up.We speculate that H.pylori might act as a trigger via direct or indirect action in the initiation of onset of gastric cancer and multiorgan Ig G4-related disease. | Min Li Qiang Zhou Kun Yang David R Brigstock Lu Zhang Ming Xiu Li Sun Run-Ping Gao | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 7 | Influence of Coal Nature and Structure on Ash Size Formation Characteristic and Related Pollutant Emissions During CFB Combustion显示文摘The size distribution of coal particles in a Circulating Fluidized Bed (CFB) boiler plays a crucial role in the complicated combustion, heat exchange and pollutant emissions in such a plat. Therefore, it is fundamental to study the different factors having influence on the size distribution of coal particles. Above all, the coal itself and in particular, the coal combination phenomenon is a very influent factor. In the frame of this work, the coal nature (elementary composition) and coal internal structure (mineral components) are studied in detail. At this intermediary stage, experiments on three typical Chinese coals on a l.5 MWt CFBC pilot plant have been made. Some primary fragmentation tests have also been made in a small lab scale fluidized bed reactor. The results from the hot pilot test show i) the variation of coal ash distributions and other CFB performance data due to the cyclone and the coal characteristics and ii) the variation of desulfurization efficiency with limestone. Whereas the bench scale primary fragmentation test, likely linked to the caking propriety of a coal, does not seem to change considerably the char size distribution. | Min QIAN Arnaud BOELLE Philippe JAUD ( Electricite de France Division R&D, 6 quai Watier B.P.49 78401 Chatou, France ) Yongjie NA Qinggang LU Shaolin BAO ding CUI Weihong JIAO Huanming ZHAO (Institute of Engineering Thermophysics, Chinese Academ | 2000 | Journal of Thermal Science2000，9，3： | 2 |
| 8 | Electricity generation from swine wastewater using microbialfuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Res2005，39，20： | 1 |
| 9 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | MIN B KIM J R OH S E | 2005 | Water Research2005，39，20： | 1 |
| 10 | Systematic review: the lower gas- trointestinal adverse effects of non-steroidal anti-inflammatory drugs 显示文摘 | Laine L Smith R Min K | 2006 | Aliment Pharmacol Ther2006，24，5： | 1 |
| 11 | Experimental models for the investigation of female sexual function and dysfunction显示文摘 | Min K O'Connell L Munarriz R | 2001 | Int J Impot Res2001，13，3： | 1 |
| 12 | Structure of 55-atom bimetallic clusters 显示文摘 | ZHANG Min FOURNIER R | 2006 | J Mol Stru : Theochem2006，762，： | 1 |
| 13 | Coal use,stove improvement,and adult pneumonia mortality in Xuanwei,China :a retrospective cohort study显示文摘 | SHEN Min CHAPMAN R S VERMEULEN R | 2009 | Environmental HealthPerspectives2009，117，2： | 1 |
| 14 | A New approach to wastewater remediation based on bifunc-tional electrodes显示文摘 | Asmussen R M Tian Min Chen Aicheng | 2009 | Environ Sci Technol2009，43，： | 1 |
| 15 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Research2005，39，20： | 1 |
| 16 | Excretion of Phosphate and Soluble Organic Phosphorous Compounds by Zooplankton 显示文摘 | POMEROY L R MATHEWS H M MIN H S | 1963 | Limnol Oceanogr1963，，8： | 1 |
| 17 | Inhibitory effects of hydrolysable tannins on Ca2+-activate hyaluronidase显示文摘 | LEE J LEE S H MIN K R | 1993 | Plant Medica1993，59，4： | 1 |
| 18 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 19 | Application of biotechno-logical tools for cooccidian vaccine development显示文摘 | Min W Dalloul R A Lillehoj H S | 2004 | Vet Sci2004，5，： | 1 |
| 20 | Kidney Toxicity In- duced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats 显示文摘 | Jeong M Kim Y W Min J R | 2012 | Toxieol Res2012，28，3： | 1 |
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