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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Molecular detection of circulating solid carcinoma cells in peripheral blood:the concept of early systemic disease显示文摘 | Mori M Minori K Ueo H | 1996 | Int J Cancer1996，68，3： | 1 |
| 3 | Spectrophotometrie method for the determination of an anionic surfactant without liquid-liquid extraction显示文摘 | MINORI KAMAYA YOKO TOMIZAWA KUNIO NAGASHIMA | 1998 | AnalyLica Chimica Acta1998，362，： | 1 |
| 4 | HIF -I a induces cell cycle arrest by functionally counteracting Myc 显示文摘 | Minori K Yuiko K Erin AP | 2004 | EMBO2004，23，9： | 1 |
| 5 | Spectrophotometric method for the determination of an anionic surfactant without liquid±liquid extraction显示文摘 | Minori Kamaya Yoko Tomizawa Kunio Nagashima | 1998 | Analytica Chimica Acta1998，362，： | 1 |
| 6 | Chronic L - NAME induced hypertension 显示文摘 | Tozef B Ellen OW Minori T | 2000 | Circulation2000，101，4： | 1 |
| 7 | Autoantibodies to calpastatin can be endogenous inhibitor for calcium dependent neutral protease (calpain), in systemic rheumatic disease显示文摘 | Minori T Suganuma K Tanami Y | 1995 | Proc Acad Sci USA1995，92，16： | 1 |
| 8 | Simple method for spectrophotometer determination of cationic surfactants without liquid-liquid extraction显示文摘 | MINORI KAMAY YOKO KANEKO KUNIO NAGASHIMA | 1999 | Analytica Chimica Acta1999，，384： | 1 |
| 9 | The application of avariable-pressure scanning electron microscope with energy dispersive X-ray microanalyser to the diagnosis of electrocution:a case report显示文摘 | Hiroshi Kinoshita Minori Nishiguchi Harumi Ouchi | 2004 | Legal Medicine2004，6，： | 1 |
| 10 | Cigarette smoking,proteinuria,and renal function in middle-aged Japanese men from an occupational population显示文摘 | Yuka Noborisaka Masao Ishizaki Minori Nakata | 2011 | Environmental Health and Preventive Medicine2011，10，2： | 1 |
| 11 | ExperimentalStudy on Grinding Fluids for Abrasive Belt Grinding of Stainless Steel显示文摘 | Minori N Mamoru K | 1985 | Journal of Japan Society of Lubrication Engineers1985，6，5： | 1 |
| 12 | Primary structures of two hemagglutinins from the marine red alga, Hypnea japonica显示文摘 | Kanji Hori Ki minori Matsubara Keisuke Miyazawa | 2000 | Biochimica et Biophysica Acta2000，1474，： | 1 |
| 13 | Human Behavior in Downtown Public Spaces during Cooling Periods in Winter Cities显示文摘 | Minori Kusaka Tsuyoshi Setoguchi Norihiro Watanabe Zhiming Guo Anasutasiia Paukaeva | 2018 | Journal of Civil Engineering and Architecture2018，12，1： | 1 |
| 14 | Biolog- ically active gibberellins and abscisic acid in fruit of two late-maturing Japanese pear cultivars with con- trasting fruit size 显示文摘 | Zhang Caixi Tanabe Kenji Mori Minori | 2007 | Journal of the American Society for Horticultural Science2007，132，4： | 1 |
| 15 | Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2)显示文摘 | Minori K Hiromitsu T Takashi N | 2006 | Biomaterials2006，27，9： | 1 |
| 16 | Experimental Study on Grinding Fluids for Abrasive Belt Grinding of Stainless Steel显示文摘 | Minori Nakayama Mamoru Kudo | 1985 | Journal of Japan Society of Lubrication Engineers1985，6，5： | 1 |
| 17 | Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcriptionpolymerase chain reaction in patients with gastrointestinal or breast carcinoma显示文摘 | Mori M Minori k Ueo H | 1998 | J Clin Oncol1998，16，1： | 1 |
| 18 | Solving tangled cases of work-related musculoskeletal disorders by international scientific cooperation显示文摘 | Nakata Minori Ahlgren Christina From Carin Lindberg Per | 2007 | New Solutions2007，，6： | 1 |
| 19 | Immobilization of heavy metal ions(CuⅡ,CdⅡ,NiⅡ,and PbⅡ)by broiler litter-derived biochars in water and soil显示文摘 | Minori U Isabel M Lima K | 2010 | Journal of Agricultural and Food Chemistry2010，58，： | 1 |
| 20 | Dowling determination of rhodamine 123 in cell lysate by HPLC with visible wavelength detection显示文摘 | TAHIRA I MINORI K THOMAS C | 2005 | J Chrom B2005，814，2： | 1 |
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