|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 3 | Clear cell sarcoma of ten-dons and aponeuroses: a review 显示文摘 | Dim D C Cooley L D Miranda R N | 2007 | Arch Pathol Lab Med2007，131，： | 1 |
| 4 | Evaluating the efficacy of dra ma therapy in teaching social skills to children with autism spec trum disorders显示文摘 | Miranda D A Corinne L Stephen S | 2015 | Drama Therapy Review2015，1，1： | 1 |
| 5 | Chromosomal location of Pm35, a novel Aegilops tauschii derived powdery mildew resistance gene introgressed into common wheat显示文摘 | Miranda L M Murphy J P Marshall D S | 2007 | Theoretical and Applied Genet-ics2007，114，8： | 1 |
| 6 | The relationship between early childhood blood lead levels and performance on end- of- grade tests 显示文摘 | MIRANDA M L KIM D GALEANO M A | 2007 | Envion Health Perspect2007，115，8： | 1 |
| 7 | Influence of shielding gases and process parameters on metal transfer and bead shape in MIG brazed joints of the thin zinc coated steel plates显示文摘 | QUINTINO L MIRANDA R | 2006 | Materials & Design2006，27，5： | 1 |
| 8 | Synthesis of spiroindolenine derivatives by a tandem radical-oxidation process显示文摘 | Zuleta-Prada H Miranda L D | | 0，，： | 1 |
| 9 | Cor- relation of the P300 evoked potential in depressive and cogni- tive aspects of aging 显示文摘 | MIRANDA E C PINHEIRO M M PEREIRA L D | 2012 | Braz J Otorhinolaryngol2012，78，5： | 1 |
| 10 | Online posture rec- ognition from pose kernel learning and decision forests 显示文摘 | MIRANDA L VIEIRA T MARTINEZ D | 2014 | Pattern Recogn Lett2014，39，1： | 1 |
| 11 | Importance of roasted sulphide concentrates characterization in the hydrometallurgical extraction of zinc显示文摘 | BALARINI J C LUDMILA de O P MIRANDA T L S CASTRO R M Z d SALUM A | 2008 | Minerals Engineering2008，21，1： | 1 |
| 12 | A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons 显示文摘 | Jimenez F P Miranda J L Pinillos M D | 2001 | Diabetologia2001，44，11： | 1 |
| 13 | Effect of con- sumption of milk from goats fed Senecio jacobaea on hepatic drug metabolizing enzyme activities in rats显示文摘 | Miranda C L Cheeke P R Goeger D E | 1981 | Toxicol Lett1981，8，： | 1 |
| 14 | Differentiation between women with vulvovaginal ymptoms who are positive or negative for Candida species by culture显示文摘 | Witkin S S Miranda S D | 2001 | Infect Dis Obstet Gynecol2001，9，4： | 1 |
| 15 | Channel catfish liver monooxygenases:immunological characterization of constitutive cytochromes P450 and the absence of active flavin-containing monooxygenases显示文摘 | Schlenk D Ronis M J J Miranda C L | 1993 | Biochem Pharmacol1993，45，1： | 1 |
| 16 | Effects of 2-methylisoborneol(MIB),and ethanol on the expression and activity of cytochrome P450s from the channel catfish显示文摘 | Schlenk D Ronis M J J Miranda C L | 1995 | J Fish Bio1995，46，2： | 1 |
| 17 | Welding with high power fiber lasers-A preliminary study显示文摘 | QUINTINO L COSTA A MIRANDA R YAPP D KUMAR V KONG C J | 2007 | Mater Design2007，28，： | 1 |
| 18 | Pm34: a new powdery mildew resistance gene transferred fromAegilops tausehiiCoss to common wheat ( Triticum aestivum L) 显示文摘 | Miranda L M Murphy J P Marshall D | 2006 | Theor Appl Genet2006，113，8： | 1 |
| 19 | Candida parapsilosis candidaemia in a neonatal unit over 7 years : a case se- ries study显示文摘 | MIRANDA L D RODRIGUES E C COSTA S F | 2012 | BMJ Open2012，2，00： | 1 |
| 20 | Rare-earth doped low silica calcium aluminosilicate glasses for near and mid infrared applications显示文摘 | Baesso M L Bento A C Miranda L C M de Souza D F Sampaio J A Nunes L A O | | 0，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员