|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 2 | Exotic Newcastle disease eradiation program in the United States of America显示文摘 | Walker J W Heron B R Mixson M A | 1973 | Avian Dis1973，17，： | 1 |
| 3 | Use of surrogate antimicrobial agents to predict susceptibility to ertapenem显示文摘 | Isaacs R Mixson LA | 2002 | Diagn Microbiol Infect Dis2002，43，： | 1 |
| 4 | Identification of a novel mutation in the gene encoding the beta-triiodothyronine receptor in a patient with apparent selective pituitary resistance to thyroid hormone 显示文摘 | Mixson AJ Renault JC Ransom S | 1993 | Clin Endocrinol1993，38，3： | 1 |
| 5 | Modified branched peptides with a histidine - rich tail enhance in vitro gene transfection 显示文摘 | Q Leng and A J Mixson | 2005 | Nucleic Acids Research2005，33，4： | 1 |
| 6 | Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice 显示文摘 | Chen QR Kumar D Stass SA Mixson AJ | 1999 | Cancer Res1999，59，14： | 1 |
| 7 | Clinical evaluation of restored maxillary incisors : veneers vs PFM crowns显示文摘 | Pippin D J Mixson JM Soldanels AP | 1995 | Am Dent Assoc1995，126，： | 1 |
| 8 | Clinical evaluation of restored maxillary incisors:Veneers vs PFM crowns 显示文摘 | Pippin DJ Mixson JM Soldan-els AP | 1995 | J Am Dent Assoc1995，126，11： | 1 |
| 9 | Clinical evaluation of restored maxillary incisors: Veneers vs PFM crowns 显示文摘 | Pippin D J Mixson JM Soldan-Els AP | 1995 | Am Dent Assoc1995，126，11： | 1 |
| 10 | Clinical evaluation of restored maxillary incisors:Veneers vs PFM crowns显示文摘 | Pippin DJ Mixson JM Soldan-els AP | 1995 | J Am Dent Assoc1995，126，11： | 1 |
| 11 | In vitro activity of ertapenem against common clinical isolates in relation to human pharmacoki-netics 显示文摘 | Friedland I Mixson LA Majumdar A | 2002 | J Chemother2002，14，5： | 1 |
| 12 | Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo 显示文摘 | Zhang L Leng Q Mixson AJ | 2005 | J Gene Med2005，7，3： | 1 |
| 13 | Ertapenem:A Parenteral Long-acting Carbapenemp显示文摘 | Moty 1 M Mixson L Friedland I R | 2003 | Clin Chim Acta2003，25，12： | 1 |
| 14 | Noise transmission and control for a light twin-engine aircraft 显示文摘 | Barton CK Mixson JS | 1981 | Journal of aircraft1981，18，7： | 1 |
| 15 | Aheration in the IL-2 signal pep- tide 'affects secretion of proteins in vitro and in vivo 显示文摘 | Zhang L Leng Q Mixson AJ | 2005 | J Gene Med2005，7，3： | 1 |
| 16 | Inferring the population structure and demographic history of the tick, Amblyomma americanum Linnaerus 显示文摘 | Mixson TR Lydy SL Dasch GA | 2006 | J Vector Ecol2006，31，1： | 1 |
| 17 | Newcastle disease cradiation program in United States of America显示文摘 | Walker J W Heron B R Mixson M A | 1973 | Avian Dis1973，17，： | 1 |
| 18 | Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome 显示文摘 | Kartsonis N Killar J Mixson L | 2005 | Antimicrob Agents Chemother2005，49，9： | 1 |
| 19 | Suppression of in- terferon-a signaling by hepatitis E virus显示文摘 | Dong C Zafhllah M Mixson H T | 2012 | Hepatology2012，55，5： | 1 |
| 20 | 利用ITS1和Cyt b位点的DNA单链空间构型多样性研究黑脚硬蜱的种群结构(英文)显示文摘黑脚硬蜱 (Ixodesscapularis)是莱姆病的主要传毒媒介。本文利用从 12个不同地点采集的 85 3个样本 ,采用DNA单连构型多样性的分子技术 (DNAsinglestrandconformationpolymorphisms)对黑脚硬蜱的种群结构进行了分析。线粒体细胞色素b (Cytb)和核糖体rRNA基因的内部转录空间ITS1被用为种群目标分子标记位点。在Cytb位点上 ,总共发现 7个单倍基因型。在ITS1位点上 ,共发现 13个基因型。基因型频率分析结果显示 ,沿美国东海岸分布的黑脚硬蜱隶属于两个不同的南北种群 ,但是基因流在地理区域间频繁发生。尽管蜱自身的迁徙扩散能力有限 ,但地理区域内个体间的遗传变异程度仍然较大 ,这可能与黑脚硬蜱寄主动物的频繁迁移有关。另外 ,本研究资料显示 。 | Tonya R. MIXSON Quentin Q. FANG D. Kelly McLAIN James H. OLIVER Jr | 2004 | 动物学报2004，50，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员