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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Increase biliary protein precedes gallstone formation显示文摘 | A Tames M Mohammad Z A Toel J R | 1994 | Digestive Diseases and Sciences1994，39，： | 1 |
| 3 | Emergy- based fuzzy optimization approach for water reuse in an eco-industrial park 显示文摘 | MOHAMMAD SADEGH TASKHIRI TAN R R CHIU A S F | 2011 | Resources Conservation and Recycling2011，55，： | 1 |
| 4 | Formation of a dense and continuous AI2O3 layer in nano thermal barrier coating systems for the suppression of spinel growth on the AI2O3 oxide scale during oxidation 显示文摘 | DAROONPARVAR M YAJ1D MUHAMAD A M YUSOF N M HUSSAIN MOHAMMAD S RAD HAMID R B | 2013 | Journal of Alloys and Compounds2013，571，： | 1 |
| 5 | A comprehensive study of the green hexafluorozirconicacid - based conversion coating 显示文摘 | Mohammadloo H E Sarabi A A Mohammad Hosseini R etal | 2014 | Progress in OrganicCoatings2014，77，2： | 1 |
| 6 | An investigation of modified couple stress theory in buckling analysis of micro composite laminated Euler-Bernoulli and Timoshenko beams显示文摘 | MOHAMMAD A M DANESHMEHR A R | 2014 | International Journal of Engineering Science2014，75，2： | 1 |
| 7 | A parameters design approach to improve product quality and equipment performance in hot rolling显示文摘 | Mohammad A Younes M Shahtout R | 2006 | Journal of Materials Processing Technology2006，171，1： | 1 |
| 8 | Brucella meningitis 显示文摘 | Hamed R A R Reza A Mohammad S | 2013 | Med J Islam Repub Iran2013，27，2： | 1 |
| 9 | An intriguing effect of lithium perchlorate dispersed on silica gel in the bromination of aromatic compounds by N-bromosuccinimide 显示文摘 | Mojtaba B Najmedin A Mohammad R S | 2005 | Canadian Journal of Chemistry2005，83，： | 1 |
| 10 | Small molecule inhibitors of Bcl-2 family proteins for pancreatic cancer therapy显示文摘 | MASOOD A AZMI A S MOHAMMAD R M | 2011 | Cancers(Basel)2011，3，2： | 1 |
| 11 | Natural convection in cavities with constant flux beating at the bottom wall and isothermal cooling from the side wall显示文摘 | Sharif M A R Mohammad T R | 2005 | Int Therm Sci2005，44，： | 1 |
| 12 | General harmonic balance solution of a cracked rotor-bearing-disk system for harmonic and sub-harmonic analysis: analytical and experimental approach 显示文摘 | MOHAMMAD A A-S BUTCHER E A STERN C R | 2010 | International Journal of Engineering Science2010，48，10： | 1 |
| 13 | High throughput screening of active phar-maceutical ingredients by UPLC显示文摘 | MOHAMMAD A A PANAGIOTA R VINCENT A | 2008 | Journal of Sepa- ration Science2008，31，12： | 1 |
| 14 | Capillary electrophoresis and its application in the clinical laboratory显示文摘 | Petersen J R Okorodudu A O Mohammad A | 2003 | Clinica Chimica Acta2003，330，12： | 1 |
| 15 | Preclinical studies of TW-37,a new nonpeptidic small-molecule inhibitor of Bcl-2,in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1显示文摘 | Mohammad R M Goustin A S Aboukameel A | | 0，，07： | 1 |
| 16 | Screening of inexpensive nitrogen sources for production of L-(+) lactic acid from starch by amylolytic Lactobacillus amylophilus GV6 in single step fermentation显示文摘 | MOHAMMAD A BASA J N GOPAL R | 2005 | Food Technol Biotechnol2005，43，： | 1 |
| 17 | Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer 显示文摘 | MOHAMMAD R GIRI A GOUSTIN AS | 2008 | Recent Patents Anticancer Drug Diseov2008，3，1： | 1 |
| 18 | Preparation of cinnamate esters from styrenes显示文摘 | Mohammad A Wayne F S Robert J R | 1997 | J Org Chem1997，62，5： | 1 |
| 19 | Multilevel zero-inflated negative binomial regres- sion modeling for over-dispersed count data with ex- tra zeros显示文摘 | Moghimbeigi A Eshraghian M R Mohammad K | 2008 | Journal of Applied Statistics2008，35，10： | 1 |
| 20 | Investigation of dimpled fins for heat transfer enhancement in compact heat exchangers 显示文摘 | Mohammad A E Ali R Daoesh K T | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
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