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| 1 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 2 | 放射损伤对外源骨髓间充质干细胞迁徙定植的影响显示文摘【目的】研究机体中枢神经系统受放射损伤时骨髓间充质干细胞(MSCs)的迁徙定植特性的改变,从而为应用MSCs治疗中枢神经系统放射损伤提供理论和实验依据。【方法】用8周龄SD大鼠接受22GyX线照射制作枢神经系统放射损伤模型;从GFP鼠抽取骨髓,分离和扩增MSCs。中枢神经系统受放射损伤的SD大鼠4个月后予静脉输注GFP-MSCs。于移植后几个时间点取脑、骨髓、肝、脾等做冰冻切片,用双光子共聚焦红外脉冲激光显微镜检测GFP-MSCs。【结果】在最早24h内实验组和对照组的骨髓中检测到外源性GFP阳性细胞,至第7天后实验组骨髓中GFP阳性细胞显著多于对照组。脑内第1天未检测到外源性GFP阳性细胞,第4天后中枢神经系统受放射损伤的SD大鼠,脑组织检测到带绿色荧光的外源性GFP阳性细胞;而对照组脑内一直未检测到带绿色荧光的外源性MSCs。实验组和对照组脾脏在输注MSCs后第1天即检测到大量GFP阳性细胞,并持续存在,第21天实验组GFP阳性细胞较对照组减少。【结论】在放射损伤条件下外源性MSCs可透过血脑屏障到达脑组织,中枢神经系统放射损伤可诱导外源性MSCs向脑组织迁徙定植。 | 罗向阳 Mohi Rezvani 夏焱 岑丹阳 何展文 李栋方 Uday Tirlapur | 2008 | 中山大学学报(医学科学版)2008，29，5： | 4 |
| 3 | A survey on herbal management of hepatocellular carcinoma显示文摘In this review we outline the different mechanisms mediating hepatocarcinogenesis. We also discuss possible targets of bioactive herbal agents at different stages of hepatocarcinogenesis and highlight their role at each individual stage. We gathered information on the most common herbal prescriptions and extracts thought to be useful in prevention or sensitization for chemotherapy in management of hepatocellular carcinoma (HCC). The value of this topic may seem questionable compared to the promise offered for HCC management by chemotherapy and radiation. However, we would recommend the use of herbal preparations not as alternatives to common chemo /and or radiotherapy, but rather for prevention among atrisk individuals, given that drug/herb interactions are still in need of extensive clarification. The bioactive constituents of various herbs seem to be promising targets for isolation, cancer activity screening and clinical evaluation. Finally, herbal preparations may offer a cost effective protective alternative to individuals known to have a high risk for HCC and possibly other cancers, through maintaining cell integrity, reversingoxidative stress and modulating different molecular pathways in preventing carcinogenesis. | Nabil Mohie Abdel-Hamid Maiiada Hasan Nazmy Ahmed Wahid Mahmoud Michael Atef Fawzy Marco Youssof | 2011 | World Journal of Hepatology2011，3，7： | 3 |
| 4 | Critical role for Gab2 in transformation by BCR/ABL显示文摘 | Sattler M Mohi M G Pride Y B | | 0，，05： | 1 |
| 5 | Preventing hospital-acquired pressure ulcers:improving quality of outcomes by placing emphasis on the Braden subscale scores显示文摘 | MoHy M G | 2012 | J WOCN2012，39，3： | 1 |
| 6 | Role of transforming growth factor- 11 in serum and -509 C>T promoter gene polymor- phism in development of liver cirrhosis in Egyptian pa- tients 显示文摘 | Mohy A Fouad A | 2014 | Meta Gene2014，9，2： | 1 |
| 7 | Validated spectrofluorimetric method for the determination of atorvastatin in pharmaceutical preparations显示文摘A rapid,sensitive and simple spectrofluorimetric method was developed for the estimation of atorvastatin.In this method,the native fluorescence characteristics of atorvastatin have been studied in both acidic and basic media.High sensitivity was obtained with 5% acetic acid at 389 nm using 276 nm for excitation.Regression analysis showed a good correlation coefficient(r=0.9995) between fluorescence intensity and concentration over the range of 1.5-4 mg/mL with detection limit of 0.012 mg/mL.The proposed method was successfully applied to the analysis of atorvastatin in pure and pharmaceutical dosage forms with average recovery of 100.2970.47%.The results were compared favorably with those of the reported method. | Mohie M.K.Sharaf El-Din Fathy M.M.Salama Mohamed W.I.Nassar Khalid A.M.Attia Mohamed M.Y.Kaddah | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 1 |
| 8 | The role of Shp2 ( PTPN11 ) in cancer显示文摘 | M Golam Mohi Benjamin G Neel | 2007 | Current Opinion in Genetics & Development2007，，1： | 1 |
| 9 | Cyclodextrin: an overview显示文摘 | Nisar KA Mohi D | 2013 | International Jour- nal of Bioassays2013，2，6： | 1 |
| 10 | Role of transforming growth factor-β1in serum and-509 C>T promoter gene polymorphism in development of liver cirrhosis in Egyptian patients显示文摘 | Mohy A Fouad A | 2014 | Meta Gene2014，2，： | 1 |
| 11 | Tyrosine 201 is required for consti-tutive activation of JAK2V617F and efficient induction of myelopro-liferative disease in mice显示文摘 | Yan D Hutchison RE Mohi G | 2012 | Blood2012，120，9： | 1 |
| 12 | Prognostic,therapeutic,and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations显示文摘 | Mohi M G Williams I R Dearolf C R | | 0，，02： | 1 |
| 13 | Critical requirement for Star5 in a mouse mode] of polycythemia vera显示文摘 | Yan D Hutchison RE Mohi G | 2012 | Blood2012，119，15： | 1 |
| 14 | Characterization the activity of penicillin G acylase immobilized onto nylon membranes grafted with different acrylic monomers by means of γ-radiation显示文摘 | MOHY M S BENCIVENGA U ROSSI S | 2000 | Journal of Molecular Catalysis B:Enzymatic2000，8，46： | 1 |
| 15 | Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs显示文摘 | Mohi MG Boulton C Gu TI | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 16 | Characteriza- tion the activity of penicillin G acylase immobilized onto nylon membranes grafted with different acrylic monomers by means of γ - radiation 显示文摘 | Mohy M Y Bencivenga U Rossi S | 2000 | Journal of Molecular Ca- talysis B : Enzymatic2000，，： | 1 |
| 17 | Physically crosslinked poly (vinyl alcohol) -hydroxyethyl starch blend hydrogel membranes: Synthesis and characterizatinn for biomedical applications显示文摘 | E1- Refaie K Elbadawy A Mohamed S Mohy E Mahmoud A | 2014 | Arabian Journal of Chemistu2014，7，3： | 1 |
| 18 | Lumbar trans- pedicular implant failure:a clinical and surgical challenge and its radiological as- sessment显示文摘 | Mohi Eldin MM Ali AM | 2014 | Asian Spine J2014，8，3： | 1 |
| 19 | Characterization of the activity of penicillin G acylase immobilized onto nylon membranes grafted with different acrylic monomers by means of γ - radiation显示文摘 | Mohy Eldin M S Bencivenga U Rossi S | 2000 | J Mol Cat B:Enzymatic2000，，： | 1 |
| 20 | Differential biological activity of disease-associated JAK2 mutants显示文摘 | Zou H Yah D Mohi G | 2011 | FEBS Lett2011，585，7： | 1 |
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