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| 1 | CoolClot,a novel hemostatic agent for controlling life-threatening arterial bleeding显示文摘BACKGROUND:Uncontrolled bleeding is the first leading cause of preventable death in the battlefield and the 2nd cause of mortality in civil accidents.Incompressible hemorrhage control is among the interventions that drastically increase the survival rate in wound individuals.We have previously shown that a certain mixture of bentonite and zeolite minerals can significantly decrease the bleeding in rats.METHODS:In this study,nine healthy hybrid dogs were selected and after induction of anesthesia with ether,either arterial puncture by a needle or arteriotomy was performed on both groin regions of the dogs.For control arteries(either the right or left femoral artery),only pressure by sterilized gauze was performed,while for the femoral arteries of the opposite side,our invented hemostatic agent,namely CoolClot,was topically used before applying the pressure.In the second stage of the study,to assess the coagulation time,blood samples were collected from 10 volunteer students.RESULTS:CoolClot significantly decreased the bleeding time in animals whose femoral arteries were cut or punctured.In the human phase of the study,the mean coagulation time in control blood samples was 253.4+44.1 seconds,whereas it was 149.5+50.0,162.3±74.6 and 143.4±114.6seconds,respectively in blood samples treated with bentonite,zeolite and CoolClot(P<0.05).CONCLUSIONS:As controlling bleeding after a life-threatening arterial damage is critical for increasing the chance of survival,the results obtained in this study indicate the significant efficacy of CoolClot in shortening the bleeding time.Our experiments also indicate that CoolClot can significantly reduce the clotting time in human blood samples. | SMJ Mortazavi A Tavasoli M Atefi N Tanide N Radpey P Roshan-shomal H Moradi S Taeb | 2013 | World Journal of Emergency Medicine2013,4,2: | 2 |
| 2 | Spatial learning deficits and emotional impairment in pentylenetetrazole- kindled rats显示文摘 | Mortazavi F Ericson M Story D | 2005 | Epilepsy Behav2005,7,4: | 1 |
| 3 | Preparation and bioactivityevaluation of bone-like hydroxyapatite nan- opowder显示文摘 | FATHI M H HANIFI A MORTAZAVI V | 2008 | Materials Process Technology2008,202,13: | 1 |
| 4 | The principles of ultra high pressure technology and its application in food processing/preservation: A review of microbiological and quality aspects显示文摘 | Yaldagard M Mortazavi S A Tabatabaie F | 2008 | AfrJ Biotechnol2008,7,: | 1 |
| 5 | East and accurate timing characterization using functional information显示文摘 | YALCIN H MORTAZAVI M PALERMO R C | 2000 | IEEE Trans CAD2000,20,2: | 1 |
| 6 | The influence of systemic therapy on the serum levels of IL-6 and IL- 8 in pemphigus vulgaris 显示文摘 | Mortazavi H Babaeijandaghi F Akbarzadeh M | 2013 | J Eur Acad Dermatol Venereol2013,27,3: | 1 |
| 7 | In ritro evaluation of the effect of canal curvature on adaptation of gutta-percha in canals obtt, rated with HERO fill system by CBCT 显示文摘 | Zarei M Talati A Mortazavi M | 2011 | J Oral Sci2011,53,1: | 1 |
| 8 | Access recircu- lation in jugular venous catheter in regular and reversed lines 显示文摘 | Atapour A Mosakazemi M Mortazavi M | 2008 | Iran J Kidney Dis2008,2,2: | 1 |
| 9 | The sensing behaviour of metal oxides (ZnO,CuO and Sm2O3) dopedSnO2 for detection of low concentrations of chlorinated volatile organic compounds显示文摘 | Aliha H M Khodadadi A A Mortazavi Y | 2013 | Sensors Actuators B:Chem2013,181,: | 1 |
| 10 | Decreased serum total T3level in hepatitis B and C related cirrhosis by severity of liver damage显示文摘 | Mansour-Ghanaei F Mehrdad M Mortazavi S | 2012 | Ann Hepatol2012,11,5: | 1 |
| 11 | Second-harmonic generation and absorption studies of polymer-dye films oriented by corona-onset poling at elevated temperatures显示文摘 | Mortazavi M A Knoesen A Kowel S T | 1989 | J Opt Soc Am B1989,6,4: | 1 |
| 12 | Total hip arthroplasty after prior surgical treatment of hip fracture显示文摘 | Mortazavi S Greenky M Bican O | 2012 | Arthroplasty2012,27,1: | 1 |
| 13 | Genome-wide mapping of in vivo protein-DNA interactions 显示文摘 | Johnson D S Mortazavi A Myers R M | 2007 | Science2007,316,5830: | 1 |
| 14 | Dynamic modelling of milk ultrafiltration by artificial neural network 显示文摘 | Razavi M A Mortazavi A Mousavi M | 2003 | Journal of Membrane Science2003,220,1: | 1 |
| 15 | 查看详情显示文摘 | Ahmadjo S Arabi H Nekoomanesh M Zohuri G.H. Mortazavi M.M.Naderi G | | 0,,: | 1 |
| 16 | Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth显示文摘 | Mortazavi M Mesbahi M | 2004 | Int J Paediatr Dent2004,14,6: | 1 |
| 17 | A modified technique for carotid cannulation via the transfemoral approach, during angioplasty and stent placement 显示文摘 | Gupta K Biria M Mortazavi A | 2008 | Tex Heart lnst J2008,35,3: | 1 |
| 18 | Preparation and bioactivity evaluation of bone - like hydroxyapatite nanopowder 显示文摘 | Fathi M H Hanifi A Mortazavi V | 2008 | Journal of Materials Processing Technology2008,202,123: | 1 |
| 19 | Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats显示文摘 | Mortazavi F Ericson M Story D | 2005 | Epilepsy Behav2005,7,: | 1 |
| 20 | Male reproductive health under threat: short term exposure 1o radiofrequency radiations emitted by common mobilejammers显示文摘 | MortazaviS Parsanezhad M Kazempour M et a | 2013 | Journal of Human Reproductive Sciences2013,6,2: | 1 |