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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Potential habitat modeling for reintroduction of three native plant species in central Iran显示文摘Potential habitat modeling of endemic species is an appropriate method to maintain biodiversity,ecosystem function and rehabilitation of rangeland ecosystems.Astragalus caragana,A.cyclophyllon and A.podolobus are endemic in Iran's rangelands and some neighboring countries.The three native species could endure environmental stresses due to their distinctive ecophysiological characteristics.They play important roles in sustainable pastures production,recreation and improvement.They suffer severe threat from many factors including;grazing,agriculture and invasive exotic species.We analyzed the potential habitat of three native plant species in central Iran basing on the grid map with the resolution of 1-km.We used inventory records from field surveys,herbarium collections and 22 environmental factors to explore the environmental influences on given species distribution by Maximum entropy(Maxent) model.Maxent is a species distribution model that uses species occurrence and environmental data for predicting potential species.The results of our study indicated species occurrence has strong correlation with environmental factors such as mean temperature of wettest season,elevation and precipitation of coldest season.We evaluated the model accuracy by AUC(area under the receiver operating characteristic curve) based on an independent test data set.AUC values indicated the high power of Maxent to create potential habitat map(AUCA.caragana=0.988,AUCA.cyclophyllon=0.927,AUCA.podolobus=0.923).It is important to consider that AUC values tend to be lower for species that have broad distribution scope,such as A.podolobus distribution.Most suitable potential habitat distributions of the three species were predicted in the western and southwestern parts of rangelands in Isfahan province.Visual comparisons of the actual distribution map of the three species with produced Maxent maps represent a good agreement.In general,the model demonstrated that the occurrence of the given species is highly probable when the elevation is between 2,200 and 3,000 m and mean temperature of wettest season less than 3°C.This model,therefore,can be applied to recognize potential sites for rangeland reclamation projects. | Elham G ARDESTANI Mostafa TARKESH Mehdi BASSIRI Mohammad R VAHABI | 2015 | Journal of Arid Land2015，7，3： | 5 |
| 3 | Experimental study of radiation and free convection in an enclosure with under-floor heating system 显示文摘 | MOSTAFA R AMIR S | 2011 | Energy Convection and Managemen2011，52，： | 1 |
| 4 | Prestressed Concrete Piles in J0intless Bridges 显示文摘 | Kamel M R Benak J V Tadros M K Mostafa J | 1996 | PCI Journal1996，41，2： | 1 |
| 5 | Synthesis and characterization of (poly (N-vinyl formamide)--pregelled starch- graft copolymer 显示文摘 | Mostafa K M Samarkandy A R E1-Sanabary A A | 2010 | J Polym Res2010，17，： | 1 |
| 6 | City Develop- ment strategies (CDS) and sustainable urbanization in develo- ping world 显示文摘 | MOSTAFA S R NURWATI B MASTURA J | 2012 | Social and Behavioral Sciences2012，，36： | 1 |
| 7 | Modelling of tornado and microburst-induced wind loading and failure of a lattice transmission tower显示文摘 | Savory Eric Parke Gerard A R Zeinoddini Mostafa | 2001 | Engineering Structures2001，23，： | 1 |
| 8 | An Experi- mental Investigation on the Fabrication of W-Cu Composite through Hot-press 显示文摘 | MOSTAFA R HAMIDREZA B HOSSEIN A | 2012 | International Journal of Industrial Chemistry2012，3，1： | 1 |
| 9 | Geochemical significance of fatty acids in crude oils and related source rocks from Egypt显示文摘 | Barakat A O EI-Gayar M Sh Mostafa A R | 2000 | Petroleum Science and Technology2000，18，56： | 1 |
| 10 | Modification of polyethylene by radiation-induced graft copolymerization of N-phenylmaleimide and p-hydroxy N-phenylmaleimide显示文摘 | Aly R O Mostafa T B Mokhtar S M | 2002 | Polym Test2002，21，： | 1 |
| 11 | A novel hybrid multi-objective shuffled frog-leaping algorithm for a bicriteria permutation flow shop scheduling problem显示文摘 | ALIREZA R V MOSTAFA D HAMED R | 2009 | International Journal of Advanced Manufacturing Technology2009，41，1112： | 1 |
| 12 | Space/time characteristics of pressure fluctuations in separation regions 显示文摘 | Mostafa N H Hajj M R Zeiger M D | 2002 | Journal of Wind Engineering and Industrial Aerodynamics2002，90，： | 1 |
| 13 | Effect of different starter cultures on the biogenic amines production as a critical control point in fresh fermented sausages 显示文摘 | Mokhtar S Mostafa G Taha R | 2012 | Eu- ropeam Food Researoh and Technology2012，235，3： | 1 |
| 14 | Challenges in the diagnosis and management of interstitial and cornual ectopic pregnancies显示文摘 | Botros R Candice PH Mostafa A | 2013 | Middle East Fertil Soc J2013，18，4： | 1 |
| 15 | Multielement determination by flame atomic absorption of road dust samples in Delta Region, Egypt显示文摘 | KHAIRY M A BARAKAT A O MOSTAFA A R | 2011 | Microchemical Journal2011，97，2： | 1 |
| 16 | A Microwave Scattering Model for Layered Vegetation 显示文摘 | Mostafa A Karam R H L | 1992 | IEEE Trans Geoscience and Remote Sensing1992，30，4： | 1 |
| 17 | Reconstructive tomography and applications to ultrasonics显示文摘 | Muller R K Mostafa K Wade G | 1979 | Proceeding of IEEE1979，67，4： | 1 |
| 18 | Novel benzimidazole-pyrimidine conjugates as potent antitumor agents显示文摘 | Beba T A ti Fatma A F R Mostafa ti R | 2010 | Eur J tied Chem2010，45，： | 1 |
| 19 | Modelling of tornado and microburst-induced wind loading and failure of a lattice transmission tower 显示文摘 | Savory Eric Parke Gerard A R Zeinoddini Mostafa | 2001 | Engineering Structures2001，23，4： | 1 |
| 20 | Adsorption of mercury lead and cadmium ions on modified activated carbons显示文摘 | MOSTAFA M R | 1997 | Adsor Sci Technol1997，15，8： | 1 |
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