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| 1 | 平寨水库荧光溶解性有机质的来源、特征及其动态转化显示文摘利用三维激发发射矩阵光谱(3?D EEM)和平行因子分析,研究了三岔河流域平寨水库溶解有机质的来源、组成和转化情况。在平寨水库的入库水、表层水(0~5 m)、深层水(10~60 m)和出库水中,检测到了几种荧光溶解有机质组分,分别为陆源类腐殖质、自源类腐殖质和浮游植物源的类蛋白质(或类色氨酸或类酪氨酸)。陆源类腐殖质的荧光强度在入库水中略高于出库水,表明陆源类腐殖质在水库系统中相对稳定,大坝截流对其影响不大。自源类腐殖质的荧光强度在库区明显高于入库水和出库水,表明自源类腐殖质既由自源有机物分解产生,又在光化学、微生物和大坝物理拦截过程的影响下发生分解;其他荧光组分中也检测到相似的结果。水温、pH、溶解氧和有色溶解有机质表现出相似的季节变化,光化学和微生物以及大坝拦截是引起水库入库水、库区表层水、库区深层水和出库水中荧光溶解有机质时空动态变化的主要原因。 | 刘奕君 原杰 王宝利 Khan Md Golam Mostofa | 2019 | 地球与环境2019，47，6： | 7 |
| 2 | New insights into estrogenic regulation of O^6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O^6-benzylguanine indicates fresh avenues for therapy显示文摘Endocrine therapy using estrogen receptor-α(ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers.To exploit any DNA repair deficiencies associated with endocrine therapy,we investigated the functional and physical interactions of ER-α with O^6-methylguanine DNA methyltransferase(MGMT),a unique DNA repair protein that confers tumor resistance to various anticancer alkylating agents.The ER-α-positive breast cancer cell lines(MCF-7,T47D) and ER- negative cell lines(MDAMB-468,MDAMB-231),and established inhibitors of ER-α and MGMT,namely,ICI-182,780(Faslodex) and O^6-benzylguanine,respectively,were used to study MGMT- ER interactions.The MGMT gene promoter was found to harbor one full and two half estrogen-responsive elements(EREs) and two antioxidant-responsive elements(AREs).MGMT expression was upregulated by estrogen,downregulated by tamoxifen in Western blot and promoter-linked reporter assays.Similarly,both transient and stable transfections of Nrf-2(nuclear factor-erythroid 2-related factor-2)increased the levels of MGMT protein and activity 3 to 4-fold reflecting novel regulatory nodes for this drugresistance determinant.Of the different ER-α antagonists tested,the pure anti-estrogen fulvestrant was most potent in inhibiting the MGMT activity in a dose,time and ER-α dependent manner,similar to O^6-benzylguanine.Interestingly,fulvestrant exposure led to a degradation of both ER-α and MGMT proteins and O^6-benzylguanine also induced a specific loss of ER-α and MGMT proteins in MCF-7 and T47 D breast cancer cells with similar kinetics.Immunoprecipitation revealed a specific association of ER-α and MGMT proteins in breast cancer cells.Furthermore,silencing of MGMT gene expression triggered a decrease in the levels of both MGMT and ER-α proteins.The involvement of proteasome in the drug-induced degradation of both proteins was also demonstrated.Fulvestrant enhanced the cytotoxicity of MGMT-targeted alkylating agents,namely,temozolomide and BCNU by 3 to 4-fold in ER-α positive cells,but not in ER-negative cells.We conclude that MGMT and ER-α proteins exist as a complex and are co-targeted for ubiquitin-conjugation and subsequent proteasomal degradation.The findings offer a clear rationale for combining alkylating agents with endocrine therapy. | Ameya Paranjpe Nathan I. Bailes Santhi Konduri George C. Bobustuc Francis Ali-Osman Mohd. A. Yusuf Surendra R. Punganuru Hanumantha Rao Madal Debasish Basak AGM Mostofa Kalkunte S. Srivenugopa | 2016 | The Journal of Biomedical Research2016，30，5： | 5 |
| 3 | In vitro callus induction and plantlet regeneration of Achyranthes aspera L.,a high value medicinal plant显示文摘Objective:To study callus induction from different explants(internode,leaf,root)and in vitro plantlets propagation from medicinally important plant Achyranthes aspera L.Methods:Sterilized explants were prepared by uning 0.1%HgCl_2 and 0.5%Bavistin and callus was obtained when cultured onto Murashige Skoog's(MS)medium by using different concentrations and combination of 2,4-D.NAA.BAP,IAA,IBA with 3%sucrose and 0.8%agar.Induced callus was immediately transferred to MS medium containing at different concentrations of phytohormones for shootlets and rootlets induction respectively.Results:Sterilization treatment of 0.1%HgCl_2.for 2-3 min and Bavistin 0.5%for 10-12 min showed the highest percentage of asepsis and survival rate.Maximum induction of callus was obtained from a combination of 2.0 mg/L 2,4-D and 0.5 mg/L NAA from leaf.Highest shootlets number(4.83±0.l7)and length(3.8±0.16)cm were observed on full strength MS medium when fortified with BAP 4.0 mg/L and KIN 0.5 mg/L.Concerted efforts of BAP 10 mg/L and NAA 0.5 mg/L on full strength MS medium showed highest leaf number(6.77±0.94).In vitro raised shoots were allowed to root on different strengths of MS medium fortified with IAA and IBA at different concentrations.Experimentally,3.0 mg/L IBA was enabled to induce maximum rootlets number(10.0±9.82)on full strength MS medium.Afterwards,regenerated shoots with well developed roots were successfully subjected to hardening process and were acclimatized.The survived plantlets showed 66.67%survival frequency without any morphological abnormality.Conclusions:The results demonstrated that different explants were good source of callus induction,morphology analysis as well as indirect plantlets regeneration. | Monokesh Kumer Sen Shamima Nasrin Shahedur Rahman Abu Hena Mostofa Jamal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 3 |
| 4 | 妊娠期基因-环境相互作用与母体砷甲基化效率显示文摘单核昔酸多态性(SNPs)主要是指在基因组水平上由单个核昔酸的变异所引起的DNA序列多态性,是人类可遗传的变异中最常见的一种,占所有已知多态性的80%以上。有研究表明,SNPs可能通过影响砷的甲基化效干扰砷代谢。而环境与基因的交互作用是否会影响孕期砷代谢目前尚不明确,因此,本研究分析SNP-砷的交互作用对砷甲基化效率的影响。 | Gao S Mostofa MG Quamruzzaman Q 李园园(编译) | 2019 | 中华预防医学杂志2019，53，5： | 2 |
| 5 | Strigolactones interact with other phytohormones to modulate plant root growth and development显示文摘Strigolactones(SLs),which are biosynthesized mainly in roots,modulate various aspects of plant growth and development.Here,we review recent research on the role of SLs and their cross-regulation with auxin,cytokinin,and ethylene in the modulation of root growth and development.Under nutrientsufficient conditions,SLs regulate the elongation of primary roots and inhibit adventitious root formation in eudicot plants.SLs promote the elongation of seminal roots and increase the number of adventitious roots in grass plants in the short term,while inhibiting lateral root development in both grass and eudicot plants.The effects of SLs on the elongation of root hairs are variable and depend on plant species,growth conditions,and SL concentration.Nitrogen or phosphate deficiency induces the accumulation of endogenous SLs,modulates root growth and development.Genetic analyses indicate cross-regulation of SLs with auxin,cytokinin,and ethylene in regulation of root growth and development.We discuss the implications of these studies and consider their potential for exploiting the components of SL signaling for the design of crop plants with more efficient soil-resource utilization. | Huwei Sun Weiqiang Li David J.Burritt Hongtao Tian Heng Zhang Xiaohan Liang Yuchen Miao Mohammad Golam Mostofa Lam-Son Phan Tran | 2022 | The Crop Journal2022，10，6： | 2 |
| 6 | Solving the multidimensional multiple-choice knap- sack problem by constructing convex hulls 显示文摘 | MOSTOFA A M SOHEL R M KAYKOBAD M | 2006 | Com- puters and Operations Research2006，33，5： | 1 |
| 7 | Characterization ofNanming River ( southwestern China ) sewerage-impactedpollution using an excitation-emission matrix and PARAFAC显示文摘 | Mostofa K M G Wu F C Liu C Q | 2010 | Limnology2010，11，3： | 1 |
| 8 | Possible underly- ing mechanisms responsible for aldosterone and mineraloeor- ticoid receptor-dependent renal injury显示文摘 | Kiyomoto H Rafig K Mostofa M | 2008 | J Phannacol Sci2008，108，4： | 1 |
| 9 | Characterization of Nanming River (southwestern China ) sewerage-impacted pollution using an excitation-emission matrix and PARAFAC 显示文摘 | Mostofa K M G Wu F Liu C Q | 2010 | Limnology2010，11，3： | 1 |
| 10 | Possible underlying mechanisms responsible for aldostemne and mineralocorti- coid receptor-dependent rehal injury显示文摘 | Kiyomoto H Rafiq K Mostofa M | 2008 | J Pharmaeol Sci2008，108，4： | 1 |
| 11 | Solving the multi-dimensional multiple-choice knapsack problem by constructing convex hulls显示文摘 | Md Mostofa Akbar Rahman M S Kaykobad M | 2006 | Computers and Operations Research2006，33，： | 1 |
| 12 | Dynamics and characteristics of flu- orescent dissolved organic matter in the groundwater, river and lake wa- ter显示文摘 | MOSTOFA K M G YOSHIOKA T | 2007 | Water Air Soil Pollution2007，184，： | 1 |
| 13 | Modeling of Minimum Uncut chip Thickness in Micro Machining of Aluminum显示文摘 | MALEKIAN M MOSTOFA M G JUN M B G | 2012 | Journal of Materials Processing Technology2012，212，： | 1 |
| 14 | Modeling of minimum uncut chip thickness in micro machining of alumi- num 显示文摘 | Malekian M Mostofa M G Park S S | 2012 | Journal of Materials Processing Technology2012，212，3： | 1 |
| 15 | Possible underlying mechanisms responsible for aldosterone and mineralocorticoid re- ceptor~tependent renal injury显示文摘 | Kiyomoto H Rafiq K Mostofa M | 2008 | J Pharmacol Sci2008，108，4： | 1 |
| 16 | Studies on the anti-nematodal ef- fects of medicatedurea-molasses-mineral blocks against gastroin- testinal nematodiasis in indigenous dairy cows of Bangladesh显示文摘 | Rafiq K Mostofa M Saiful M | 2004 | Pakistan Journal of Biological Sciences2004，7，1： | 1 |
| 17 | Arsenic poisoning of in groundwater: Health risk and geochemical sources in bangladesh 显示文摘 | Anawar H M Akai J Mostofa K M G | 2002 | Environment International2002，27，7： | 1 |
| 18 | 饮用水中砷减少与皮肤损害改善:孟加拉国的后续研究显示文摘摘要:[背景]慢性砷暴露与皮肤损害相关。然而,尚不知道减少砷暴露是否会改善皮肤损害。[目的]评估随时间的推移,砷暴露减少与皮肤损害恢复之间的关联。[方法]在2001-2003年间孟加拉国登记的基线皮肤损害病例(n=900)的基础上,于2009-2011年随访研究550名患者。确定基线及随访时饮用水和脚趾甲中的砷与皮肤损伤的状态及严重程度。 | Wei Jie Seow Wen-Chi Pan Molly L.Kile Andrea A.Baccarelli Quazi Quamruzzaman Mahmuder Rahman Golam Mahiuddin Golam Mostofa Xihong Lin David C.Christiani | 2013 | 环境与职业医学2013，30，3： | 1 |
| 19 | Therapeutic competence of dried garlic powder (Al-lium sativum) on biochemical parameters in lead(Pb) exposed broiler chickens 显示文摘 | HOSSAIN M A AKANDA M R MOSTOFA M etal | 2014 | Journal of Ad-vanced Veterinary and Animal Research2014，1，4： | 1 |
| 20 | Spatial and temporal variations and factors controlling the concentrations of hydrogen peroxide and organic peroxides in rivers 显示文摘 | MOSTOFA K M G SAKUGAWA H | 2009 | Environmental Chemistry2009，6，6： | 1 |
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