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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSⅡ) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade显示文摘 | Wu F N Mueller L A Crouzillat D Petiard V Tanksley S D | 2006 | Genetics2006，174，： | 1 |
| 3 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
| 4 | Regulation of vascular endothelial growth factor(VEGF) gene transcription by estrogen receptors alpha and beta显示文摘 | MUELLER M D VIGNE J L MINCHENKO A | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 5 | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor显示文摘 | Villeneuve D L Mueller N D Martinovic D | 2009 | Environ Health Perspect2009，117，62： | 1 |
| 6 | Mu- tation of a new gene encoding a putative pyrin-like protein cau- ses familial cold autoinflammatory syndrome and Muckle- Wells syndrome显示文摘 | HOFFMAN H M MUELLER J L BROIDE D H | 2001 | Nat Genet2001，29，3： | 1 |
| 7 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 8 | Novel placental and nonplacental serum markers in ectopic versus normal intrauterine pregnancy 显示文摘 | Mueller M D Raio L Spoerri S | 2004 | Fertil Steril2004，81，4： | 1 |
| 9 | Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants显示文摘 | Sattler S.E Mene-Saffrane L Farmer E.E Krischke M Mueller M.J and DellaPenna D | | 0，，： | 1 |
| 10 | Phenotypic enhancement of longevity by environmental urea in Drosophila melanogaste显示文摘 | JOSHI A S J MUELLER L D | 1996 | Experimental Gerontology1996，31，： | 1 |
| 11 | Histopathology of 30 non- operated acoustic schwannomas 显示文摘 | Eckermeier L Pirsig W Mueller D | 1979 | Eur Arch Olo Rhino Laryngol1979，222，1： | 1 |
| 12 | Practical application of pheromone traps in food and tobacco industry显示文摘 | Mueller D Pierce L Benezet H | 1990 | J Kansas Entomol1990，63，： | 1 |
| 13 | A snapshot of the emerging tomato genome sequence显示文摘 | Mueller L A Lankhorst R K Tanksley S D | 2009 | Plant Genome2009，2，： | 1 |
| 14 | Hyperbaric oxygen treatment for carbon monoxide poisoning in pregnancy:a case report显示文摘 | Brown D B Mueller G L Golich F C | | 0，，11： | 1 |
| 15 | Use of soybean hulls with or with-out corn by-product protein sources in feedlot backgrounding diets显示文摘 | Mueller C J Boggs D L | | 0，，03： | 1 |
| 16 | Coding of sweet, bitter, and umami tastes : different receptor cells sharing similar signaling pathways显示文摘 | Zhang Y Hoon M A Chandrashekar J Mueller K L Cook B Wu D | 2003 | Cell2003，112，： | 1 |
| 17 | Three-dimensional vector radiative transfer in a semi-infinite, Rayleigh scattering medium exposed to spatially varying polarized radiation: generalized reflection matrix 显示文摘 | MUELLER Jr D W CROSBIE A L | 2002 | J of Quantitative Spectroscopy and Radiative Transfer2002，75，： | 1 |
| 18 | The Role of Rural-Urban Migration in the Structural Transformation of Sub-Saharan Africa 显示文摘 | Brauw A D Mueller V Lee H L | 2013 | Economic Transformation in Afric2013，10，13： | 1 |
| 19 | Effects of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition 显示文摘 | ZELTINGER J SHEERWOOD J K GRAHAM D M MUELLER R GRIFFITH L G | 2001 | Tissue Eng2001，7，5： | 1 |
| 20 | Critical discussion of the results from different corrosion studies of Mgand Mg alloys for biomaterial applications 显示文摘 | Mueller W D Nascimento M L Mele M F L | 2010 | Acta Biomaterialia2010，6，5： | 1 |
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