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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | Bovine lactofemn supplementation supports immune and antioxidant status in healthy human males显示文摘 | MULDER A M CONNELLAN P A OLIVER C J | 2008 | Nutrition Research2008，28，： | 1 |
| 4 | Maternal segregation of the Dutch preeclampsia locus at lOq22 with a new member of the winged helix gene family显示文摘 | van Dijk M Mulders 1 Poutsma A | 2005 | Nat Genet2005，37，5： | 1 |
| 5 | Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification显示文摘 | Frijters C T M J Eikelboom D H Mulder A | 1997 | Water Science Technology1997，36，1： | 1 |
| 6 | Multifunctional gold nanoparticles for diagnosis and therapy of disease显示文摘 | MIESZAWSKA A J MULDER W J M FAYAD Z A | 2013 | Molecular pharmaceutics2013，10，3： | 1 |
| 7 | Design of a haptic gas pedal for active car-fol- lowing support显示文摘 | MULDER M ABBINK D A VAN PAASSEN M M | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，1： | 1 |
| 8 | Analysing container flows in Caribbean 显示文摘 | VEENSTRA A W MULDER H M | 2005 | Journal of Transport Geography2005，13，： | 1 |
| 9 | Pulmonary vein anatomy and long-term outcome after multi-electrode pulmonary vein isolation with phased radiofrequency energy for paroxysmal atrial fibril ation显示文摘 | Mulder A Wijffels M Wever E | | 0，，11： | 1 |
| 10 | Cardiopulmonary resuscitation:Errors- made by prehospital emergency medical personnel显示文摘 | Liberman M Lavoie A Mulder D | 1999 | Resuscitation1999，42，1： | 1 |
| 11 | Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification显示文摘 | Eikelboom D H Mulder A | 1997 | Water Science and Technology1997，36，： | 1 |
| 12 | Raman Analysis of the Initial Stages of the Hydrolysis and Polymerization of Tetrae thylorthosilicate显示文摘 | Mulder C A M Damen A A J M | 1987 | Journal of Non-crystalline Solids1987，93，1： | 1 |
| 13 | Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family显示文摘 | Van Dijk M Mulders J Poutsma A | 2005 | Nat Genet2005，37，5： | 1 |
| 14 | Evaluating the Performance of an Integrated Navigation System显示文摘 | Lorga J F M Chu Q P Mulder J A | 2005 | 2005，，： | 1 |
| 15 | Treatment of municipal wastewater in a circox airlift reactor with integrated denitrification 显示文摘 | FRIJTERS C T M J EIKELBOOM D H MULDER A | 1997 | Water Science Technology1997，36，1： | 1 |
| 16 | Advances in the application of remote sensing and GIS for surveying mountainous land显示文摘 | MULDERS M A | 2001 | International Journal of Applied Earth Observation and Geo-information2001，3，1： | 1 |
| 17 | Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV显示文摘 | COOPER M MULDER J VAN RHIJN A | 2005 | Food Additives and Contaminants2005，，22： | 1 |
| 18 | Separation of isomeric xylenes by pervaporation through cellulose ester membranes显示文摘 | Mulder M H V Kruitz F Smolders C A | 1982 | J Membr Sci1982，11，： | 1 |
| 19 | gE of PRV determines virulence and facilitates penetration of the virus into CNS of pigs显示文摘 | Jacobs L Mulder W A M Enquist LW | 1994 | Acta Vet Hung1994，42，23： | 1 |
| 20 | Dynamics of nitric oxide and nitrous oxide emission during full-scale reject water treatment 显示文摘 | Kampsehreur M J Vander W R L Wielders H A Mulder J W Jetten M S M van Loosdrecht M C M | 2008 | Water Research2008，42，3： | 1 |
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