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| 1 | Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis显示文摘AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis. | Ichiro Hirata Shingo Yasumoto Ken Toshina Takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu | 2007 | World Journal of Gastroenterology2007，13，11： | 20 |
| 2 | BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy显示文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed 'reduced volume method'(group A) with the 'conventional volume method'(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method. | Yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri | 2012 | World Journal of Gastroenterology2012，18，17： | 8 |
| 3 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 4 | Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases显示文摘AIM:To evaluate prospectively usefulness of fecal lactoferrin(Lf)and fecal hemoglobin(Hb)in the diagnosis of colorectal diseases.METHODS:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal endoscopy.RESULTS:Lf was positive in 18(50%)of 36 patients with colorectal cancer,25(15.9%)of 157 with colorectal polyps,29(46.8%)of 62 with ulcerative colitis,and 25(62.5%)of 40(62.5%)with Crohn's disease.The Hb-positive rates were 50%,12.1%,41.9% and 32.5%,respectively.Of the 318 patients free of abnormalities by colorectal endoscopy,Lf was positive in 29(9.1%)and Hb was positive in 15(4.7%).Among patients with Crohn's disease,the Lf-positive rate was significantly higher than the Hb-positive rate.If either high Lf or Hb levels were considered positive,the positive rates rose to 61.1%,51.6%,and 67.5% in the colorectal cancer group,ulcerative colitis group,and Crohn's disease group,respectively.If both high Lf and Hb levels were rated positive,the positive predictive values(PPV)were 21% for colorectal cancer,33% for ulcerative colitis,and 17% for Crohn's disease,and PPV of high Hb level alone was 18%,25% and 13%,respectively.CONCLUSION:Fecal Lf and Hb were found useful in the detection of colorectal diseases,and the combination of the two measurements appears to increase the sensitivity and efficacy of diagnosis. | Ichiro Hirata Masahiro Hoshimoto Osamu Saito Masanobu Kayazawa Takashi Nishikawa Mitsuyuki Murano Ken Toshina Fang-Yu Wang Ryoichi Matsuse | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 5 | Serum-free culture of H pylori intensifies cytotoxicity显示文摘AIM: To perform a long culture passage of H pylori without serum, taking into account its cytotoxicity and the presence of the probable new cytotoxic factor. METHODS: One sample of H pylori 60190 (ATCC 49503) was grown on Brain Heart Infusion (BHI) agar containing 0.5% 2,6-di-O-methyl-β-cyclodextrin without any serum, being passaged 70-100 times every 3-4 d for approximately 2 h, while another sample of H pylori contained 70 mL/L fetal calf serum without 2,6-di-O- methyl-β-cyclodextrin. Their supernatant and extract after 16 h in culture were evaluated for changes in cell morphology and for cell viability using HeLa cells. Furthermore, the characteristics of the probable cytotoxic factor in the extract were examined on partial purification studies and its cytotoxicity was evaluated in various human cells. RESULTS: The supernatant and the extract of the bacterium grown on serum-free medium had strong cytotoxicity compared with those grown on serum- containing medium. They irreversibly damaged HeLa cells without vacuolation that was altogether different from that of the bacterium when grown with serum. Their cytotoxicity was easily measured by cell viability assay. The probable cytotoxic factor partially purified and detected by chromatography had characteristics difference from that of vacuolating toxin and a broad cytotoxicity toward various cell lines. CONCLUSION: Serum-free long culture method of H pylori makes its supernatant and its extract cytotoxic enough to be easily measured by cell viability assay. The probable cytotoxic factor has a unique characteristic and might be a new cytotoxin. | Hiroyuki Ohno Akiyuki Murano | 2007 | World Journal of Gastroenterology2007，13，4： | 2 |
| 6 | Modulation of proand antifibrinolyticproperties of human peritoneal mesotheial cells by transforming growth factor betal, tumor necrosis factor alpha and IL-1beta显示文摘 | Tietze L Elbrecht A Murano G | 1998 | Thromb Haemost1998，79，2： | 1 |
| 7 | Interaction of endothelial cells and triglyceride-rich lipoproteins with apoliprotein E (Arg-》Cys) from a patient with lipoprotein glomerulopathy显示文摘 | Murano T Matsumura R Misawa Y | 2002 | Metabolism2002，51，： | 1 |
| 8 | Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC显示文摘 | Rubio-Cabezas 0 Puri V Murano I Saudek V Semple RK Dash S | 2009 | Emho Mol Med2009，，5： | 1 |
| 9 | Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice显示文摘 | Murano I Barbatelli G Parisani V | | J Lipid Res0，49，7： | 1 |
| 10 | Electricity generation from cysteine in a microbial fuel cell显示文摘 | Logan BE Murano C Scott K | 2005 | Water Res2005，39，5： | 1 |
| 11 | Identification of a marine agarolytic Pseudoalteromonas isolate and characterization of its extracellular agarase显示文摘 | Vera J Alvarez R Murano E | 1998 | Applied and Enviromental Microbiology1998，64，11： | 1 |
| 12 | Monophasic epithelial synovial sarcoma arising in the temporomandibular joint显示文摘 | Bukawa H Kawabata A Murano A | 2007 | Int J Oral Maxillofac Surg2007，36，8： | 1 |
| 13 | Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS) -induced colitis 显示文摘 | Murano M Maemura K Hirata I | 2000 | Clin Exp Immunol2000，120，1： | 1 |
| 14 | Prevalence of Salmonella and Campylobacter in Beef cattle from transport to slaughter显示文摘 | Beach JC Murano EA Acuff GR | 2002 | J Food Prot2002，65，： | 1 |
| 15 | Therapeutic effect of intracolonically administered nuclear factor kappa B(p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis显示文摘 | MURANO M MAEMURA K HIRATA l | 2000 | Cli n Exp Immunol2000，120，1： | 1 |
| 16 | Simvastatin attenu- ates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis 显示文摘 | Abe Y Murano M Murano N | 2012 | Dig Dis Sci2012，57，： | 1 |
| 17 | Electricity gener- ation from cysteine in a microbial fuel cell 显示文摘 | Logan B E Murano C Scott K | 2005 | Water Res2005，39，： | 1 |
| 18 | Electricity genera- tion from cysteine in a microbial fuel cell显示文摘 | Logan B E Murano C Scott K | 2005 | Water Res2005，39，： | 1 |
| 19 | Identification of a Marine Agarolytic Pseuddoalteromonas Isolate and Characterization of Its Extracellular Agarase显示文摘 | VERA J ALVAREZ R MURANO E | | 0，，01： | 1 |
| 20 | Prevalence of Salmonella and campylobacter in beef cattle from transport to slaughter 显示文摘 | Beach JC Murano EA Acuff GR | 2002 | J Food Prot2002，65，： | 1 |
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