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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 4 | The CD200 receptor is a novel and potent regulator of murine and human mast cell function显示文摘 | MURPHY C A JOYCE B L | 2005 | J Immunol2005，174，： | 1 |
| 5 | The effects of sulfonate molecular weight and salt concentration on the interracial tension of oil-brine-surfactant systems显示文摘 | Nillson P M Murphy C L Foster W R | 1976 | SPE58121976，，： | 1 |
| 6 | Utility of SSRs for determining genetic similarities and relationships in maize using an agarose gel system显示文摘 | SENIOR M L MURPHY J P GOODMAN M M | 1998 | Crop Sci1998，38，： | 1 |
| 7 | Board of Director Performance Reporting显示文摘 | McIntyre M L Murphy S A | 2008 | Corporate Govemance2008，，8： | 1 |
| 8 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 9 | Association of vegetable, fruit, and grain intakes with colorectal cancer : the Multiethnic Cohort Study显示文摘 | Nomura A M Y Wilkens L R Murphy S P | 2008 | Am J Clin Nutr2008，88，： | 1 |
| 10 | Utility of SSRs for determining genetic similarities and relationships in maize using an agarose gel system显示文摘 | Senior M L Murphy J P Goodman M M | 1998 | Crop Science1998，38，： | 1 |
| 11 | Virus taxonomy, 6th Report of the International Committee on Taxonomy of Viruses (ICTV) 显示文摘 | Murphy F A Fauquet C M Bishop D H L | 1995 | Arch Virol1995，10，： | 1 |
| 12 | Utility of SSRs for determining genetiv simitarities and realationships in maize using an agarose get system显示文摘 | Senior M L Murphy J P Goodman M M | 1998 | Grop Sci1998，，38： | 1 |
| 13 | al,Regression of uterine leiomyomata in response to the anti-progesterone RU486显示文摘 | MURPHY A A KETTEL L M MORALES A J et | 1993 | J Clin Endoerinol Metab1993，76，： | 1 |
| 14 | Validation of an acceleratedsol-vent extraction liquid chromatography-tandem mass spectrometry methodfor Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neu-roblastoma assay显示文摘 | WU J J MAK Y L MURPHY M B | 2011 | Anal Bioanal Chem2011，400，9： | 1 |
| 15 | Proteomic analysis of multi- drug - resistance mechanisms in adriamycin - resistant variants of DLKP, a squamous lung cancer cell line 显示文摘 | Keenan J Murphy L Henry M | 2009 | Proteomics2009，9，6： | 1 |
| 16 | What's wrong with my mouse model?Advances and strategies in animal modeling of anxiety and depression显示文摘 | KALUEFF A V WHEATON M MURPHY D L | 2007 | Behav Brain Res2007，179，1： | 1 |
| 17 | Overview of biacore systems and their applications显示文摘 | Jason-Moiler L Murphy M Bruno J | 2006 | Curr Protoe Protein Sei2006，19，： | 1 |
| 18 | Sonoelectrochemistry:chlorine,hydrogen and oxygen evolution at platinised platinum显示文摘 | Walton D J Burke L D Murphy M M | 1996 | E lectrochimica Acta1996，41，17： | 1 |
| 19 | Clinical Outcome of congenital talipes equinonarus diagnosed antenatally by ultrasound显示文摘 | Tiller T L Fisk N M Murphy K | 2000 | J Bone Joint Surg2000，82，： | 1 |
| 20 | Changes in Relative Wages, 1963-1987: Supply and Demand Factors 显示文摘 | Katz L F Murphy M K | 1992 | The Quarterly Joumal of Economies1992，107，1： | 1 |
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