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| 1 | Electroacupuncture on PC6 Prevents Opioid-Induced Nausea and Vomiting after Laparoscopic Surgery显示文摘Objective:To investigate the treatment time dependence of electroacupuncture(EA) on Neiguan (PC6) for preventing postoperative nausea and vomiting(PONV).Methods:One hundred and seventy-eight patients,who had received intravenous patient-controlled analgesia(PCA) with Fentanyl,were assigned randomly to three groups using random numbers:a pre-operative EA group(PrEA),a post-operative EA group(PoEA),and a non-acupuncture control group(NC).An anesthetist evaluated the incidence and severity of nausea and vomiting for 48 h after surgery blindly.The main outcomes were severity and freguency of PONV,which were measured with a self-reported questionnaire and a confirmation from the anesthetist.The data were analyzed with ANOVA and Z-test.Results:The incidence of nausea and vomiting was significantly lower in the PrEA group than the NC group during 48 h after surgery(P<0.01,P<0.05).The incidence of vomiting was also significantly lower in the PrEA group than the PoEA group(P<0.05).The PoEA subjects evidenced no significant differences compared with the NC subjects in terms of the incidence of nausea and vomiting(P<0.05).The severity of nausea was significantly lower in the PrEA group than in the NC and PoEA groups(P<0.05).Conclusions:EA on PC6 is effective in the prevention of PONV,and pre-operative acupuncture is more effective than post-operative acupuncture. | Siwoo Lee Myeong Soo Lee Deok Hwa Choi Su Kyung Lee | 2013 | Chinese Journal of Integrative Medicine2013，19，4： | 32 |
| 2 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 3 | BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis显示文摘有气孔的运动在为在植物纸巾和空气之间的光合作用和水平衡调整煤气的交换是批评的。植物荷尔蒙 abscisic 酸(骆驼毛的织物) 戏在在各种各样的不能生活的压力下面调整有气孔的闭合给角色调音。在这研究,我们在警卫房间骆驼毛的织物发信号揭示了 BAK1 的一个新奇角色。我们发现表明变异的 bak1 的 brassinosteroid (BR ) 比野类型的植物失去了更多的水并且在有气孔的闭合显示出骆驼毛的织物 insensitivity。导致骆驼毛的织物的 OST1 表示和生产也是的反应的氧种类(ROS ) 在 bak1 损害了。有 H 2 OST1 的 O 2, overexpression 完全没救 bak1 的 insensitivity 到骆驼毛的织物。我们证明 BAK1 在血浆膜附近与 OST1 形成建筑群并且 BAK1/OST1 建筑群在 planta 响应骆驼毛的织物被增加。Brassinolide,最活跃的 BR,在 BAK1/OST1 建筑群和 OST1 表示的导致骆驼毛的织物的形成上施加了否定效果。而且,我们发现 BAK1 和 ABI1 相对地调整 OST1 phosphorylation invitro,和那 ABI1 与 BAK1 交往并且禁止 BAK1 和 OST1 的相互作用。一起拿,我们的结果建议 BAK1 在警卫房间调整导致骆驼毛的织物的有气孔的闭合。 | Yun Shang Changbo Dai Myeong Min Lee June M. Kwak Kyoung Hee Nam | 2016 | Molecular Plant2016，9，3： | 13 |
| 4 | Acupuncture for Pain:An Overview of Cochrane Reviews显示文摘Objective:Cochrane reviews have the reputation for being more transparent and rigorous than other reviews.The aim of this overview was to evaluate and summarize Cochrane reviews of acupuncture for the treatment of any type of pain.Methods:We searched the Cochrane Database and evaluated the Cochrane reviews that were concerned specifically with the effectiveness of acupuncture for pain.Data were extracted according to pre-defined inclusion criteria by two independent reviewers.Results:Eight Cochrane reviews were included.They were all of high methodological quality.They related to a wide range of pain syndromes.Four reviews concluded that acupuncture is effective for migraines,neck disorders,tensiontype headaches,and peripheral joint osteoarthritis;one review failed to demonstrate the effectiveness of acupuncture for rheumatoid arthritis;and three reviews were inconclusive for shoulder pain,lateral elbow pain,and low back pain.Conclusion:Several Cochrane reviews of acupuncture for a wide range of pain conditions have recently been published.All of these reviews were of high quality.Their results suggest that acupuncture is effective for some but not all types of pain. | Myeong Soo Lee Edzard Ernst | 2011 | Chinese Journal of Integrative Medicine2011，17，2： | 12 |
| 5 | Probiotic modulation of dendritic cells co-cultured with intestinal epithelial cells显示文摘AIM:To investigate cytokine production and cell surface phenotypes of dendritic cells (DC) in the presence of epithelial cells stimulated by probiotics.METHODS:Mouse DC were cultured alone or together with mouse epithelial cell monolayers in normal or inverted systems and were stimulated with heat-killed probiotic bacteria,Bifidobacterium lactis AD011 (BL),Bifidobacterium bifidum BGN4 (BB),Lactobacillus casei IBS041 (LC),and Lactobacillus acidophilus AD031 (LA),for 12 h.Cytokine levels in the culture supernatants were determined by enzyme-linked immunosorbent assay and phenotypic analysis of DC was investigated by flow cytometry.RESULTS:BB and LC in single-cultured DC increased the expression of I-Ad,CD86 and CD40 (I-Ad,18.51 vs 30.88,46.11;CD86,62.74 vs 92.7,104.12;CD40,0.67 vs 6.39,3.37,P < 0.05).All of the experimental probiot-ics increased the production of inflammatory cytokines,interleukin (IL)-6 and tumor necrosis factor (TNF)-α.However,in the normal co-culture systems,LC and LA decreased the expression of I-A d (39.46 vs 30.32,33.26,P < 0.05),and none of the experimental probiotics increased the levels of IL-6 or TNF-α.In the inverted coculture systems,LC decreased the expression of CD40 (1.36 vs-2.27,P < 0.05),and all of the experimental probiotics decreased the levels of IL-6.In addition,BL increased the production of IL-10 (103.8 vs 166.0,P < 0.05) and LC and LA increased transforming growth factor-β secretion (235.9 vs 618.9,607.6,P < 0.05).CONCLUSION:These results suggest that specific probiotic strains exert differential immune modulation mediated by the interaction of dendritic cells and epithelial cells in the homeostasis of gastrointestinal tract. | Ji Yeun Kim Myeong Soo Park Geun Eog Ji | 2012 | World Journal of Gastroenterology2012，18，12： | 10 |
| 6 | Scalp Acupuncture for Parkinson's Disease:A Systematic Review of Randomized Controlled Trials显示文摘Objective:To evaluate the effectiveness of scalp acupuncture(SA),a modern acupuncture technique specialized to neurological disorders,in managing motor function and symptoms for Parkinson’s disease(PD) patients.Methods:Two independent reviewers extracted data from all of the randomized clinical trials(RCTs) that assessed the efficacy of SA for PD compared with conventional therapies(CTs). Sixteen electronic databases were searched.The risk of bias was appraised with the Cochrane Collaboration tool,and the reporting of the included studies was evaluated by the Consolidated Standards of Reporting Trials(CONSORT) 2010 checklist and the revised Standards for Reporting Interventions in Clinical Trials of Acupuncture(STRICTA) guidelines.Results:In total,4 RCTs met the inclusion criteria.As assessed by the Unified PD Rating Scale(UPDRS),2 RCTs showed that SA combined with CTs proved superior to CTs alone [60 cases;weighted mean difference,-3.94;95%confidence interval(CI),-6.05 to -1.84,P=0.01;l^2=0%]. Based on the Webster scale,however,3 RCTs showed no superior effect of SA when combined with CTs with high heterogeneity(154 cases;risk ratio,1.29;95%CI,0.79 to 2.12,P=0.30;I^2=84%).The Cochrane risk of bias,adherence to the CONSORT and the STRICTA checklist showed that the quality of all the included RCTs was generally low.Conclusions:The result of our systematic review and meta-analysis suggested that the effectiveness of SA for PD is promising,however,the evidence is not convincing.A sham-controlled RCT design that adheres to the CONSORT and STRICTA guidelines to overcome methodological weakness and that includes a large sample size is strongly recommended to confirm the precise effect of SA on PD. | Hun-Soo Lee Hye-Lim Park Seung-Jin Lee Byung-Cheul Shin Jun-Yong Choi Myeong Soo Lee | 2013 | Chinese Journal of Integrative Medicine2013，19，4： | 10 |
| 7 | 中草药对治疗癌症恶病质动物模型有效性的系统性回顾(英文)显示文摘本综述总结利用中草药治疗癌症恶病质的临床前研究及其潜在的机制,是首个针对中草药治疗癌症恶病质动物模型成效进行系统性回顾评价的研究。本文通过检索PubMed、EMBASE、Allied and Complementary Medicine Database以及Web of Science四大代表性的资料库(检索时间至2016年12月),就中草药治疗癌症恶病质的随机对照动物试验进行系统性回顾分析,并采用CAMARADE评分清单进行质量评价。分析结果显示:在十四项中草药及其化合物中,除了姜黄素外其他如黄连、黄连素、病得灵、清暑益气汤、黄芩、补中益气汤、六君子汤、橙皮苷、苍术呋喃烃、十全大补汤、小柴胡汤、知母及黄柏等都已被证实可以通过抗炎、调节神经内分泌途径、调节泛素蛋白酶体系统或蛋白质合成来改善癌症恶病质的症状。因此,利用中草药治疗癌症恶病质是一种有效的方法。然而该结论尚需要有更详细的分子机制和活性化合物的实验研究验证。 | Bongki PARK Sooseong YOU William C.S.CHO Jun-Yong CHOI Myeong Soo LEE | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，1： | 9 |
| 8 | Acupuncture for Bell's Palsy:A Systematic Review and Meta-analysis显示文摘Objective:To assess the clinical evidence for and against acupuncture as a treatment for Bell's palsy.Methods:We conducted a literature search of 15 databases from their inception to December 2010 without language restrictions.We included all randomized clinical trials(RCTs) regardless of their controls. Methodological quality was evaluated using the Cochrane risk of bias assessment tool.Results:Of the 3474 articles,only eight RCTs met our inclusion criteria.Four RCTs tested the effects of acupuncture against drug therapy on disease response rate.The meta-analysis of these data showed significant improvements in the acupuncture group[n=463,risk ratio(RR)=1.07,95%CI:1.02 to 1.13;P=0.006,l^2=0%].Six RCTs tested the effects of acupuncture plus drug therapy versus drug therapy alone.The meta-analysis of this set of RCTs also showed the favorable effects of acupuncture on disease response rate(n=512,RR=1.11,95%CI:1.05 to 1.17; P=0.001,l^2=13%).Conclusions:The evidence supporting the effectiveness of acupuncture for treating Bell's palsy is limited.The number and quality of trials are too low to form firm conclusions.Further rigorous RCTs are warranted but need to overcome the many limitations of the current evidence. | Jong-In Kim Myeong Soo Lee Tae-Young Choi Hyangsook Lee Hyo-Jung Kwon | 2012 | Chinese Journal of Integrative Medicine2012，18，1： | 8 |
| 9 | Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma显示文摘Myeong Jun Song,Si Hyun Bae,Chung-Hwa Park,Jeong Won Jang,Jong Young Choi,Seung Kew Yoon,Department of Internal Medicine,College of Medicine,The Catholic University of Korea,Seoul 137-040,South Korea Ie Ryung Yoo,Department of Nuclear,Medicine College of Medicine,The Catholic University of Korea,Seoul 137-040,South Korea Ho Jong Chun,Byung Gil Choi,Hae Giu Lee,Department of Radiology,College of Medicine,The Catholic University of Korea,Seoul 137-040,South | Myeong Jun Song Si Hyun Bae Ie Ryung Yoo Chung-Hwa Park Jeong Won Jang Ho Jong Chun Byung Gil Choi Hae Giu Lee Jong Young Choi Seung Kew Yoon | 2012 | World Journal of Gastroenterology2012，18，25： | 8 |
| 10 | Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B显示文摘AIM:To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS:A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows:(1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS:During the median follow-up period of 18.2 mo (range:5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range:1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range:4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION:Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consolidation treatment (≥ 15 mo) in younger patients is important for producing better prognosis in HBeAg positive chronic hepatitis B. | Myeong Jun Song Do Seon Song Hee Yeon Kim Sun Hong Yoo Si Hyun Bae Jong Young Choi Seung Kew Yoon Yong-Han Paik June Sung Lee Hyun Woong Lee Hyung Joon Kim | 2012 | World Journal of Gastroenterology2012，18，43： | 7 |
| 11 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 12 | Outcome of transarterial chemoembolization-based multi-modal treatment in patients with unresectable hepatocellular carcinoma显示文摘AIM:To investigate the efficacy and safety of transarterial chemoembolization(TACE)-based multimodal treatment in patients with large hepatocellular carcinoma(HCC).METHODS:A total of 146 consecutive patients were included in the analysis,and their medical records and radiological data were reviewed retrospectively.RESULTS:In total,119 patients received TACE-based multi-modal treatments,and the remaining 27 received conservative management.Overall survival(P<0.001)and objective tumor response(P=0.003)were significantly better in the treatment group than in the conservative group.After subgroup analysis,survival benefits were observed not only in the multi-modal treatment group compared with the TACE-only group(P=0.002)but also in the surgical treatment group compared with the loco-regional treatment-only group(P<0.001).Multivariate analysis identified tumor stage(P<0.001)and tumor type(P=0.009)as two independent pre-treatment factors for survival.After adjusting for significant pre-treatment prognostic factors,objective response(P<0.001),surgical treatment(P=0.009),and multi-modal treatment(P=0.002)were identified as independent post-treatment prognostic factors.CONCLUSION:TACE-based multi-modal treatments were safe and more beneficial than conservative management.Salvage surgery after successful downstaging resultedin long-term survival in patients with large,unresectable HCC. | Do Seon Song Soon Woo Nam Si Hyun Bae Jin Dong Kim Jeong Won Jang Myeong Jun Song Sung Won Lee Hee Yeon Kim Young Joon Lee Ho Jong Chun Young Kyoung You Jong Young Choi Seung Kew Yoon | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 13 | Stretchable and colorless freestanding microwire arrays for transparent solar cells with flexibility显示文摘Transparent solar cells(TSCs)are emerging devices that combine the advantages of visible transparency and light-toelectricity conversion.Currently,existing TSCs are based predominantly on organics,dyes,and perovskites;however,the rigidity and color-tinted transparent nature of those devices strongly limit the utility of the resulting TSCs for realworld applications.Here,we demonstrate a flexible,color-neutral,and high-efficiency TSC based on a freestanding form of n-silicon microwires(SiMWs).Flat-tip SiMWs with controllable spacing are fabricated via deep-reactive ion etching and embedded in a freestanding transparent polymer matrix.The light transmittance can be tuned from ~10 to 55% by adjusting the spacing between the microwires.For TSCs,a heterojunction is formed with a p-type polymer in the top portion of the n-type flat-tip SiMWs.Ohmic contact with an indium-doped ZnO film occurs at the bottom,and the side surface has an Al2O3 passivation layer.Furthermore,slanted-tip SiMWs are developed by a novel solventassisted wet etching method to manipulate light absorption.Finite-difference time-domain simulation revealed that the reflected light from slanted-tip SiMWs helps light-matter interactions in adjacent microwires.The TSC based on the slanted-tip SiMWs demonstrates 8%efficiency at a visible transparency of 10% with flexibility.This efficiency is the highest among Si-based TSCs and comparable with that of state-of-the-art neutral-color TSCs based on organic–inorganic hybrid perovskite and organics.Moreover,unlike others,the stretchable and transparent platform in this study is promising for future TSCs. | Sung Bum Kang Ji-Hwan Kim Myeong Hoon Jeong Amit Sanger Chan Ul Kim Chil-Min Kim Kyoung Jin Choi | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 14 | Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats显示文摘AIM: To investigate the protective effects of electroacupuncture (EA) pretreatment on acetylsalicylic acid (ASA)-induced ulceration in rats. METHODS: We randomly divided 72 rats into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured. RESULTS: The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group. CONCLUSION: These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components. | Hye Suk Hwang Kyung-Ju Han Yeon Hee Ryu Eun Jin Yang Yoo Sung Kim Sang Yong Jeong Young-Seop Lee Myeong Soo Lee Sung Tae Koo Sun-Mi Choi | 2009 | World Journal of Gastroenterology2009，15，8： | 7 |
| 15 | Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers worldwide. Surgery, percutaneous ablation and liver transplantation are the only curative treatment modalities for HCC. However, the majority of patients have unresectable disease at diagnosis. Therefore, effective treatment options for patients with advanced HCC are required. In advanced HCC, according to current international guidelines, sorafenib, a molecular targeted agent, is the standard treatment. However, alternative treatment modalities are required because of the low response rates and unsuitability of molecular agents in real practice. In various treatment modalities, mostly in Asia, hepatic arterial infusion chemotherapy(HAIC) has been applied to advanced HCC with a view to increasing the therapeutic efficacy. HAIC provides direct drug delivery into the tumor feeding vessels and also minimizes systemic toxicities through a greater first-pass effect in the liver. However, the sample sizes of studies on HAIC have been small and large randomized trials are still lacking. In this article, we describe the treatment efficacy of HAIC for advanced stage HCC and discuss future therapeutic possibilities. | Myeong Jun Song | 2015 | World Journal of Gastroenterology2015，21，13： | 7 |
| 16 | Conservation and Diversification of the SHR-SCR- SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots显示文摘部分地, Arabidopsis thaliana 根的功能的内皮的开发被 GRAS 抄写因素控制,也就是短根(SHR ) ,衣衫褴褛的人(SCR ) ,并且像衣衫褴褛的人 23 (SCL23 ) 。最近, SHR-SCR-SCL23 规章的模块为内皮的说明也是必要的,这被显示出(作为捆鞘知道) 在叶子。与在根对 SHR-SCR-SCL23 规章的网络的角色被知道的相比,不过, SHR, SCR,和 SCL23 的分子的相互作用更不在射击被理解。这里,我们证明 SHR 与 SCL23 形成蛋白质建筑群在射击调整 SCL23 的抄写,类似于 SCR 的规定模式表示。我们的结果显示 SHR 充当主人管理者直接激活 SCR 和 SCL23 的表示。在 SHR-SCR-SCL23 网络,我们发现了一以前 SCL23 调制 SHR 的否定反馈循环铺平的 uncharacterized。通过分子、基因、生理、词法的分析,我们也表明 SHR-SCR-SCL23 模块在内皮的形成起一个关键作用(作为淀粉鞘知道) 在胚轴。一起拿,我们的结果在根和射击在内皮开发提供新卓见进 SHR-SCR-SCL23 网络的规章的角色。 | Eun Kyung Yoon Souvik Dhar Mi-Hyun Lee Jae Hyo Song Shin Ae Lee Gyuree Kim Sejeong Jang Ji Won Choi Jeong-Eun Choe Jeong Hoe Kim Myeong Min Lee Jun Lim | 2016 | Molecular Plant2016，9，8： | 6 |
| 17 | Acupuncture for Treating Attention Deficit Hyperactivity Disorder:A Systematic Review and Meta-Analysis显示文摘Objective:To assess the effectiveness of acupuncture as a treatment option for attention deficit hyperactivity disorder(ADHD).Methods:The literatures were searched using 15 databases,including MEDLINE, AMED,CINAHL,EMBASE,Psyclnfo,the Cochrane Central Register of Controlled Trials,the Cochrane Database of Systematic Reviews,six Korean medical databases and two Chinese databases without language restritions.Prospective controlled clinical studies of any type of acupuncture therapy for ADHD autistic patients were included.Trials in which acupuncture was part of a complex intervention were also included.All articles were read by two independent reviewers,who extracted data from the articles according to predefined criteria. Risk of bias was assessed using the Cochrane risk of bias tool.Results:Of 114 articles,only three randomized clinical trials(RCTs) met our inclusion criteria.One RCT found that electroacupuncture(EA) plus behavioural treatment was superior to sham EA plus behavioural treatment.Two RCTs reported a significant benefit of acupuncture or auricular acupuncture over conventional drug therapies.Conclusions:Limited evidence exists for the effectiveness of acupuncture as a symptomatic treatment of ADHD.Given that the risk of bias of the included studies was high,firm conclusions cannot be drawn. | Myeong Soo Lee Tae-Young Choi Jong-In Kim Lakhyung Kim Edzard Ernst | 2011 | Chinese Journal of Integrative Medicine2011，17，4： | 6 |
| 18 | Moxibustion for Managing Type 2 Diabetes Mellitus:A Systematic Review显示文摘客观艾灸当前被使用在东方亚洲国家把糖尿病 mellitus (DM ) 当作非药干预。这系统的评论试图为管理类型 2 DM 病人的症状评估艾灸的有效性。 | Tae-Hun Kim Tae-Yong Choi Byung-Cheul Shin Myeong Soo Lee | 2011 | Chinese Journal of Integrative Medicine2011，17，8： | 6 |
| 19 | Red Ginseng for Type 2 Diabetes Mellitus:A Systematic Review of Randomized Controlled Trials显示文摘客观红人参(RG,人参属人参 C ·迈耶) 是为对待类型 2 糖尿病 mellitus (DM ) 的广泛地使用的植物之一。然而,为类型 2 DM 的 RG 的有效性的系统的评论都不是可得到的。这系统的评论试图与类型 2 DM 在病人为 RG 的有效性评估当前的证据。 | Sina Kim Byung-Cheul Shin Myeong Soo Lee Hyangsook Lee Edzard Ernst | 2011 | Chinese Journal of Integrative Medicine2011，17，12： | 5 |
| 20 | Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis显示文摘AIM: To evaluate the prognostic factors and efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis. METHODS: Fifty hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) were treated using hepatic arterial infusion chemotherapy (HAIC) via a subcutaneously implanted port. The epirubicin-cisplatin-5-fluorouracil (ECF) chemotherapeutic regimen consisted of 35 mg/m 2 epirubicin on day 1, 60 mg/m 2 cisplatin for 2 h on day 2, and 500 mg/m 2 5-fluorouracil for 5 h on days 1-3. The treatments were repeated every 3 or 4 wk. RESULTS: Three (6%) of the 50 patients achieved a complete response (CR), 13 (26%) showed partial responses (PR), and 22 (44%) had stable disease (SD).The median survival and time to progression were 7 and 2 mo, respectively. After 2 cycles of HAIC, CR was achieved in 1 patient (2%), PR in 10 patients (20%) and SD in 26 patients (52%). Significant pre-treatment prognostic factors were a tumor volume of < 400 cm 3 (P = 0.01) and normal levels of protein induced by vitamin K absence or antagonist (PIVKA)-Ⅱ (P = 0.022). After 2 cycles of treatment, disease control (CR + PR + SD) (P = 0.001), PVTT response (P = 0.003) and α-fetoprotein reduction of over 50% (P = 0.02) were independent factors for survival. Objective response (CR + PR), disease control, PVTT response, and combination therapy during the HAIC were also significant prognostic factors. Adverse events were tolerable and successfully managed. CONCLUSION: HAIC may be an effective treatment modality for advanced HCC with PVTT in patients with tumors < 400 cm 3 and good prognostic factors. | Do Seon Song Si Hyun Bae Myeong Jun Song Sung Won Lee Hee Yeon Kim Young Joon Lee Jung Suk Oh Ho Jong Chun Hae Giu Lee Jong Young Choi Seung Kew Yoon | 2013 | World Journal of Gastroenterology2013，19，29： | 5 |
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