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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | 铁鞣新方法显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上呈的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，9： | 4 |
| 3 | 铁鞣新方法(续)显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上乘的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，11： | 2 |
| 4 | A study of platelet aggregation, thromboxane A2 and prostacyclin in central aortic and coronary sinus blood in ischemic heart disease显示文摘 | Bhargava B Chandra N | 1994 | Indian Heart J1994，46，4： | 1 |
| 5 | Chlamydia pneumoniae exposure and inflammatory markers in acaute coronary syndrome (CIMACS) 显示文摘 | Chandra HR CHoudhary N O' Neil C | 2001 | Am J Cardiol2001，88，3： | 1 |
| 6 | Crystal doping aided by rapid expansion of supercritical solutions 显示文摘 | Chandra V Matthew J M Thomas E N | 2002 | AAPS Pharm-SciTech2002，3，4： | 1 |
| 7 | A review of single-phase improved power quality AC-DC converters显示文摘 | Singh B Singh B N Chandra A | 2003 | IEEE Trans on Industrial Electronics2003，50，5： | 1 |
| 8 | A novel process for making radiopaque materials using bauxite-Red mud 显示文摘 | Amritphale S S Anshul A Chandra N | 2007 | Journal of the European Ceramic Society2007，27，4： | 1 |
| 9 | Gabapentin versus nortriptyline in post-herpetic neuralgia patients: a randomized, double-blind clinical trial-the GONIP Trial 显示文摘 | Chandra K Shafiq N Pandhi P | 2006 | Int J Clin Pharmaeol Ther2006，44，8： | 1 |
| 10 | Prospects of molecular markers in Fusarium species diversity显示文摘 | Chandra N S Wulff E G Udayashankar A C et ol | 2011 | Applied Microbiology and Bioteehnology2011，90，： | 1 |
| 11 | Chemistry and structural evaluation of dif-ferent phospholipase A2 inhibitors in arachidonic acidpathway mediated inflammation and snake venom toxicity显示文摘 | Narendra Sharath Chandra J N Ponnappa K C Sadashi-va C T | 2007 | Curr Top Med Chem2007，7，8： | 1 |
| 12 | Sol-gel synthesis of ZnO thin films显示文摘 | Kamalasanan M N Chandra S | 1996 | Thin Solid Films1996，，288： | 1 |
| 13 | Nitric oxide as a unique bioactive signaling messenger in physiology and pathophysi- ology 显示文摘 | TUTEJA N CHANDRA M TUTEJA R | 2004 | J Biomed Biotechnol2004，2004，4： | 1 |
| 14 | Sol-gel synthesis of ZnO thin films 显示文摘 | KAMALASANAN M N CHANDRA S | 2000 | Thin Solid Films2000，288，： | 1 |
| 15 | An in vitro injury model for SH-SY5Y neuroblastoma cells: effect of strain and strain rate 显示文摘 | Skotak M Wang F Chandra N | 2012 | J Neurosci Meth2012，205，1： | 1 |
| 16 | Analysis of Energy Balance when Using Cohesive Zone Models to Simulate fracture processes显示文摘 | Shet C Chandra N | 2002 | ASME Journal of Engineering Material and Technology2002，，124： | 1 |
| 17 | Differential display of genome subsets containing specific interspersed repeats显示文摘 | Broude N E Chandra A Smith C L | 1997 | Proceeding National Academy Sciences USA1997，94，： | 1 |
| 18 | Pressure induced structural transformation of pyrochlore Gd2Zr2O7 显示文摘 | Kumar n r Chandra n v Shekar c | 2008 | Solid State Commun2008，147，35： | 1 |
| 19 | Luminescence induced by elastic deformation of ZnS: Mn nanoparticles 显示文摘 | Chandra B P Xu C N Yamada H | 2010 | Journal of Luminescence2010，130，3： | 1 |
| 20 | A Review of Three-Phase Improved Power Quality AC-DC Converters 显示文摘 | Singh B Singh B N Chandra A | 2004 | IEEE Transac- tions on Industrial Electronics2004，51，3： | 1 |
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