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| 1 | Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages显示文摘OBJECTIVE: This study aimed to evaluate whether Hwangryunhaedoktang(HHT), a herbal compound, has an inhibitory effect on lipopolysaccharide(LPS)-induced inflammation in RAW264.7 macrophages.METHODS: The effects of HHT were evaluated by confirming nitric oxide(NO) production and expression of inducible NO synthase(iN OS) and mitogen-activated protein kinases(MAPKs) in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB(NF-κB). The secretion and expression of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were determined via enzyme-linked immunosorbent assay and Western blot analyses.RESULTS: HHT suppressed LPS-induced NO production and expression of iN OS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT.CONCLUSION: HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation. | Byung Hyuk Han Yun Jung Lee Jung Joo Yoon Eun Sik Choi Seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee | 2017 | Journal of Integrative Medicine2017，15，4： | 5 |
| 2 | Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells显示文摘OBJECTIVE: To define the effects of Xanthoceras sorbifolia(EXS) on vascular inflammation and the mechanisms in endothelial cells.METHODS: Vascular protective effects of an ethanol extract of seeds from EXS(1-50 μg/mL) against tumor necrosis factor-α(TNF-α)-induced vascularinflammation were examined in human umbilical vein endothelial cells(HUVECs).RESULTS: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin,in a dose-dependent manner. Pre-treatment with EXS significantly inhibited translocation and transcriptional activity of nuclear factor-κB(NF-κB) increased by TNF-α. EXS also significantly inhibited formation of intracellular reactive oxygen species(ROS). Moreover, the vascular protective effects of EXS were linked to up-regulation of heme oxygenase-1(HO-1) and nuclear factor E2-related factor-2(Nrf-2) expression. EXS-induced HO-1 expression was significantly decreased in SnPP(HO-1 inhibitor)-and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX(CoPP)(HO-1 inducer)-treated cells. In addition, pretreatment with EXS increased HO-1 and Nrf-2 expression under TNF-α stimulation with or without N-acetyl-L-cysteine. Furthermore, the inhibitory effects of EXS on TNF-α-induced vascular inflammation were partially reversed in SnPP-and of HO-1siRNA-treated cells but increased by CoPP.CONCLUSION: These results suggest that EXS may have important implications for prevention of vascular complications associated with vascular inflammation by inhibition of the NF-κB/ROS pathway and activation of the Nrf-2/HO-1 pathway. | Jung Joo Yoon Byung Hyuk Han Eun Sik Choi Seung Namgung Da Hye Jeong Song Nan Jin Yun Jung Lee Dae Gill Kang Ho Sub Lee | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 3 | Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve显示文摘瞄准:Hominis 胎盘(HP ) 的摘录作为一个代理人在东方药被使用了改进生理的功能。现在的学习被进行调查在一个试验性的臀部的神经损害动物模型的 HP 处理是否在在损害以后改革周围神经纤维上生产支持生长的效果。方法:在 HP 被注入一个臀部的神经损害地点以后,在蛋白质层次的变化被西方的弄污和染色分析的免疫荧光在再生神经区域分析。为对轴索新生的量的评价,一种后退的跟踪技术被用来识别相应于改革轴突的神经元细胞体,并且在有教养的背侧根的神经突长出的程度轧了感觉神经元从经历了一处臀部的神经挤压伤的动物准备了的神经胶质( DRG )在神经原收集前的 7 d 被分析。结果:在受伤臀部的神经的轴索的联系生长的蛋白质(GAP-43 ) 的正式就职层次被 HP 处理提高。HP 处理(Cdc2 ) 也,在调整两极分裂周期 2 上面,蛋白质在受伤臀部的神经的远侧的树桩铺平。导致的 Cdc2 蛋白质在 Schwann 房间被检测,建议那项 Cdc2 激酶活动可以涉及改革经由 Schwann 房间增长的轴突的支持生长的活动。由后退的跟踪的房间身体测量显示 HP 治疗在改革马达轴突产生了重要增加。最后,有教养的 DRG 感觉神经元的 HP 处理显著地增加了神经突树枝状和延伸。结论:HP 支持受伤臀部的轴突的新生由在调整象 GAP-43 和 Cdc2 那样的新生相关的蛋白质因素的合成上面。 | Tae-beom SEO In-sun HAN Jin-hwan YOON In-chan SEOL Yun-sik RIM Hyun-kyung JO Joung-jo AN Kwon-eui HONG Young-bae SEO Dong-hee KIM Seung-kiel PARK Deok-chun YANG Uk NAMGUNG | 2006 | Acta Pharmacologica Sinica2006，27，1： | 2 |
| 4 | Successful Experiences of ABO-Incompatible Adult Living Donor Liver Transplantation In a Single Institute: No Immunological Failure in 10 Consecutive Cases显示文摘 | G.-W. Song S.-G. Lee S. Hwang C.-S. Ahn D.-B. Moon K.-H. Kim T.-Y. Ha D.-H. Jung G.-C. Park J.-M. Namgung C.-S. Park H.-W. Park Y.-H. Park | 2013 | Transplantation Proceedings2013，，1： | 2 |
| 5 | Multifunctional silicananotubes for dual-modality gene delivery and MR imaging 显示文摘 | Namgung R Zhang Y Fang QL | 2011 | Biomaterials2011，32，11： | 1 |
| 6 | Reduced serum osteocalcin andl, 25-dihydroxyvitamin D concentrations and low bone mineral content in small for gestational age infants: evidence of decreased bone formation rates显示文摘 | Namgung R Tsang R C Specker B L | 1993 | The Journal of Pediatrics1993，122，2： | 1 |
| 7 | Calcium-independent CaMKII activeity is involved in ginsenoside Rb1-mediated neuronal recovery after hypoxic damage显示文摘 | Park Jk Namgung U Lee CJ | 2005 | Life Sci2005，76，： | 1 |
| 8 | Long - term potentiation in vivo in the intact mouse hippocampus显示文摘 | Namgung UK Valcort E Routtenberg A | 1995 | Brain Research1995，689，1： | 1 |
| 9 | Controlling the growth and differentiation of human mesenchymal stem ceils by the arrangement of individual carbon nano tubes显示文摘 | NAMGUNG S BAIK K Y PARK J | 2011 | ACS Nano2011，5，： | 1 |
| 10 | A study on the social networks effectiveness to prevent the lonely death of the elderly who live alone显示文摘 | Kim Y S Lee C M Namgung S J | 2011 | Social Science Research2011，50，2： | 1 |
| 11 | Arsenic Induces Apoptosis in Rat Cerebellar'Neurons via Activation of JNK3 and p38 MAP Kinases显示文摘 | NAMGUNG U XIA Z | 2001 | Toxicol Appl Pharmacol2001，174，： | 1 |
| 12 | Correlation between KOH concentration and surface properties of AZ91 magnesium alloy coated by plasma electrolytic oxidation 显示文摘 | KO Y G NAMGUNG S SHIN D H | 2010 | Surface and Coatings Technology2010，205，7： | 1 |
| 13 | Graphene oxide- polyethylenimine nanoeonstruct as a gene delivery vector and bioimaging tool显示文摘 | Kim H Namgung R Singha K | 2011 | Bioeonjug Chem2011，22，12： | 1 |
| 14 | Mechanical and electrical re- sponses of nanostructured Cu-3 wt% Ag alloy fabricated by ECAP and cold rolling 显示文摘 | Ko Y G Namgung S Lee B U | 2010 | Journal of Alloys and Compounds2010，504，1： | 1 |
| 15 | Low total body bone mineral content and high bone resorption in Korean winter born versus summer bom newborn infants显示文摘 | Namgung R Tsang C Lee C | 1998 | J Pediatr1998，132，3： | 1 |
| 16 | Correlation between KOH concentration and surface properties of AZ91 magnesium alloy coated by plasma electrolytic oxidation显示文摘 | Ko Y G Namgung S Shin D H | 2010 | Surface and Coatings Technology2010，205，7： | 1 |
| 17 | The influence of thread geometry on implant osseointegration under immediate loading : a literature review 显示文摘 | Ryu HS Namgung C Lee JH | 2014 | J Adv Prosthodont2014，6，6： | 1 |
| 18 | Peritoneal metastatic goblet-(:ell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy 显示文摘 | YOUN SI NAMGUNG H YUN JS | 2015 | Ann Coluproetol2015，31，2： | 1 |
| 19 | Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogenactivated protein kinase显示文摘 | Namgung U Xia Z | 2000 | J Neurosci2000，20，17： | 1 |
| 20 | Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-Terminal proteins kinase3 and p38 mitogen-activated protein kinase 显示文摘 | Namgung UK Xia ZG | 2001 | J Neuros2001，20，7： | 1 |
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