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| 1 | Creep parameters in a die-cast Mg-A1- Ca alloy显示文摘 | Yoshihiro T Naoya I Tatsuo S | 2007 | Materials Transactions2007，48，9： | 1 |
| 2 | Design of humanized antibodies: from anti-Tac to Zenapax显示文摘 | Naoya T Paul RH Shankar K | 2005 | Methods2005，36，1： | 1 |
| 3 | Design technigues to reduce power consumption for ARM946E-S core显示文摘 | NAOYA S MASAKAZU U YASUHIRO T | 2005 | Oki Tekunikaru Rebyu2005，72，3： | 1 |
| 4 | Development of a micro total analysis system incorporating chemilumines- cence detection 'and application to detection of cancer markers显示文摘 | KAZUHIKO T NAOYA J RIICHIRO N | 2005 | Anal Chem2005，77，： | 1 |
| 5 | Purification and characterization of an acid trehalase from Acidobacterium capsulatum 显示文摘 | Kenji I Naoya U Takashi T | 2001 | J Biosci Bioeng2001，91，2： | 1 |
| 6 | Sequential evaluation of continuous deformation field of semi-crystalline polymers during tensile deformation accompanied by neck propagation显示文摘 | Makoto U Naoya T | 2011 | International Journal of Plasticity2011，27，12： | 1 |
| 7 | Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo显示文摘AIM:To generate an adenoviral vector specifically targeting the EphA2 receptor(EphA2R) highly expressed on pancreatic cancer cells in vivo.METHODS:YSA,a small peptide ligand that binds the EphA2R with high affinity,was inserted into the HI loop of the adenovirus serotype 5 fiber knob.To further increase the specificity of this vector,binding sites for native adenoviral receptors,the coxsackie and adenovirus receptor(CAR) and integrin,were ablated from the viral capsid.The ablated retargeted adenoviral vector was produced on 293T cells.Specifi c targeting of this novel adenoviral vector to pancreatic cancer was investigated on established human pancreatic cancer cell lines.Upon demonstrating specifi c in vitro targeting,in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.RESULTS:Ablation of native cellular binding sites reduced adenoviral transduction at least 100-fold.Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor.YSA-mediated transduction was inhibited by addition of synthetic YSA peptide.The transduction specificity of the ablated retargeted vector towards human pancreatic cancer cells was enhanced almost 10-fold in vitro.In a subsequent in vivo study in a nude(nu/nu) mouse model however,no increased adenoviral targeting to subcutaneously growing human pancreas cancer nodules was seen upon injection into the tail vein,nor upon injection into the peritoneum.CONCLUSION:Targeting the EphA2 receptor increases specificity of adenoviral transduction of human pancreatic cancer cells in vitro but fails to enhance pancreatic cancer transduction in vivo. | Michael A van Geer Conny T Bakker Naoya Koizumi Hiroyuki Mizuguchi John G Wesseling Ronald PJ Oude Elferink Piter J Bosma | 2009 | World Journal of Gastroenterology2009，15，22： | 1 |
| 8 | Ten-user truly asynchronous gigabit OCDMA transmission experiment with a 511-chip SSFBG en/decoder显示文摘 | HAMANAKA T WANG Xu NAOYA Wada | 2006 | Journal of Lightwave Technology2006，24，1： | 1 |
| 9 | Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin 显示文摘 | Naoya T Masashi K Satoru I | 2006 | Am J Respir Cell Mol Biol2006，35，： | 1 |
| 10 | Purification and character- ization of an acid trehalase from Acidobacterium capsulatum 显示文摘 | KENJI I Naoya U Takashi T | 2001 | Journal of Bioscience and Bioengineering2001，91，2： | 1 |
| 11 | Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin显示文摘 | KITAMURA T ASAI Naoya ENOMOTO A | 2008 | Nature Cell Biology2008，10，3： | 1 |
| 12 | Design techniques to reduce power consumption for ARM946E-S core显示文摘 | Naoya S Masakazu U Yasuhiro T | 2005 | Oki Tekunikaru Rebyu2005，72，3： | 1 |
| 13 | Fabrication and characterization of chemically crosslinked keratin films 显示文摘 | Toshizumi T Naoya O Kiyoshi Y | 2004 | Materials Science and Engineering: C2004，24，3： | 1 |
| 14 | Electromechanical properties of Nd-doped Bi4Ti3O12 films:a candidate for lead-free thin-film piezoelectrics显示文摘 | Hiroshi M Naoya I Daichi T | 2003 | Appl Phys Lett2003，82，11： | 1 |
| 15 | Excimer UV processing of (Bi,Nd)4Ti3O12 ferroelectric thin films by chemical solution deposition method显示文摘 | Takashi H Naoya I Daichi T | 2003 | Jpn J Appl Phys2003，42，9： | 1 |
| 16 | Compositional design of Pb(Zr, Ti)O3 for highly reliable ferroelectric memories显示文摘 | Naoya I Tsuneo T Yoshihiro H | 2002 | IEEE Trans Electron Devices2002，49，： | 1 |
| 17 | Novel technique to control inner and outer diameter of calcium-alginate hydrogel hollow microfibers, and immobilization of mammalian cells 显示文摘 | Takayuki T Naoya K Shinji S Koei K | 2010 | Biochemical Engineering Journal2010，49，1： | 1 |
| 18 | Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia 显示文摘 | YOSHINOR! T NAOYA M NAOKI I | 2002 | J Urol2002，167，6： | 1 |
| 19 | Studies on biological effects of ion beams on lethality,molecular nature of mutation,mutation rate,and spectrum of mutation phenotype for mutation breeding in higher plants显示文摘 | Atsushi T Naoya S Yoshihiro H | 2010 | J Radiat Res2010，51，3： | 1 |
| 20 | Relationship between Periodon- titis- Related Antibody and Frequent Exacerbations in Chronic Ob- structive Pulmonary Disease显示文摘 | Tamaki T Shigeo M Naoya T | 2012 | Plosone2012，7，7： | 1 |
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