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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | 加拿大基层医疗改革的创新型及多元化策略显示文摘基层医疗卫生服务体系在世界各国的医疗卫生服务系统中均发挥着重要作用。在过去十年中,加拿大省及地方卫生系统运用了多种方法改善基层医疗卫生服务,改革方案涵盖了目标医疗组织架构、医疗服务者薪酬、医疗服务者数量、医疗服务质量及安全性等方面,改革成果大大提升了家庭医学这个专业实践领域的吸引力,家庭医学吸引了越来越多的医学应届毕业生。这对我国健全基层医疗卫生服务体系具有重要借鉴意义。为此,本刊特别翻译和报道了加拿大基层医疗改革的创新型及多元化策略,敬请关注! | Erin Strumpf Jean-Frédéric Levesque Natalie Coyle Brian Hutchison Marsha Barnes Robert J.Wedel 魏亚萌 | 2015 | 中国全科医学2015，18，31： | 4 |
| 4 | Human disease modeling with induced pluripotent stem cells显示文摘 | Alan Trounson Kelly A Shepard Natalie D DeWitt | 2012 | Current Opinion in Genetics & Development2012，，5： | 2 |
| 5 | Insulin resistance of stress:sites and mechanism显示文摘 | Brandi LS Santoro D Natali A | 1993 | Clin Sci1993，85，5： | 1 |
| 6 | EPDM based heat shielding materials for solid rocket motors: A comparative study of different fibrous reinforcements 显示文摘 | Natali M Rallini M Puglia D | 2013 | Polymer Degra- dation and Stability2013，98，11： | 1 |
| 7 | Development of Organizational Commitment During the First Year of Employment: A Longitudinal Study of Pre - and Post - Entry Influ- ences 显示文摘 | JOHN P MEYER D RAMONA BOBOCEL NATALIE J ALLEN | 1991 | Journal of Management1991，17，： | 1 |
| 8 | Glutamine attenuates endotoxin-induced lung metabolic dysfunction:potential role of enhanced heat shock protein 70显示文摘 | Kristen D S Natalie S Anirban B | 2005 | Nutrition2005，21，： | 1 |
| 9 | AFC tracking algorithms显示文摘 | Natali F D | 1984 | IEEE Transactions on Communication1984，32，8： | 1 |
| 10 | The role of physical activity in the prevention of osteoporosis in postmenopausal women—An update显示文摘 | Natalie M. Schmitt Jochen Schmitt Martina D?ren | 2009 | Maturitas2009，，1： | 1 |
| 11 | AFC tracking algorithms 显示文摘 | Natali F D | 1984 | IEEE Transactions on Communications1984，32，8： | 1 |
| 12 | Thermo-dynamic properties of cubane显示文摘 | Kybett B D Carroll S Natalis P | 1966 | J Arh Chem Soc1966，88，3： | 1 |
| 13 | AFC Tracking Algorithms显示文摘 | Natali F D | 1984 | IEEE TransCommun1984，32，8： | 1 |
| 14 | The Stroma of Higher Plant Plastids Contain ClpP and ClpC,Functional Homologs of Escherichia coli ClpP and ClpA:An Archetypal Two-Component ATP-Dependent Protease显示文摘 | John S Natalie D John M | 1995 | The Plant Cell1995，7，： | 1 |
| 15 | AFC Tacking Algorithms显示文摘 | Francis D Natali | 1984 | IEEE transactions on communications1984，32，8： | 1 |
| 16 | High-temperature modal survey of a hot-structure control surface显示文摘 | Natalie D Spivey | 2011 | NASA/TM-2011-2159652011，21，： | 1 |
| 17 | Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase显示文摘 | Eike-Christin von Leitner Anna Klinke Dorothee Atzler Jessica L. Slocum Natalie Lund Jan T. Kielstein Renke Maas Robin Schmidt-Haupt Michaela Pekarova Olaf Hellwinkel Dimitrios Tsikas Louis G. D?Alecy Denise Lau Stephan Willems Lukas Kubala Heimo Ehmke Th | 2011 | Circulation2011，，24： | 1 |
| 18 | Long-term response to cal- cium-channel blockers in non-idiopathic pulmonary arterial hyper- tension 显示文摘 | Montani D Savale L Natali D | 2010 | Eur Heart J2010，31，15： | 1 |
| 19 | Initiation growth and cryopreservation of plant cell suspension cultures 显示文摘 | Natali R Ward D Frank V | 2011 | Na- ture Protocols2011，6，： | 1 |
| 20 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
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