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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | New serological markers in pediatric patients with inflammatory bowel disease显示文摘The spectrum of serological markers associated with inflammatory bowel disease(IBD)is rapidly growing.Due to frequently delayed or missed diagnoses,the application of non-invasive diagnostic tests for IBD,as well as differentiation between ulcerative colitis(UC)and Crohn’s disease(CD),would be useful in the pediatric population.In addition,the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody(pANCA)improved the sensitivity of serological markers in pediatric patients with CD and UC.Some studies suggested that age-associated differences in the patterns of antibodies may be present,particularly in the youngest children.In CD,most patients develop stricturing or perforating complications,and a significant numberof patients undergo surgery during the disease course.Based on recent knowledge,serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery.Pediatric UC is characterized by extensive colitis and a high rate of colectomy.In patients with UC,high levels of antiCBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis.Thus,serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression.In conclusion,identification of patients at an increased risk of rapid disease progression is of great interest,as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD,and reduce complications and hospitalizations. | Márta Kovács Katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 3 | Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the Southwest Region of Cameroon显示文摘Background:Tuberculosis(TB)remains a global health challenge and depression is a significant contributor to the global burden of disease.Current evidence suggests that there is an association between depressive symptoms and TB,lower adherence to treatment,and increased morbidity and mortality.However,there is paucity of data regarding these associations in Cameroon.This study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB(PTB)in the Southwest Region of Cameroon.Methods:A hospital-based cross-sectional study involving 265 patients with PTB was conducted from 2nd January to 31st March 2015 in the Limbe Regional Hospital and the Kumba District Hospital.Depression was diagnosed using the standard nine-item Patient Health Questionnaire,and classified as none,mild or moderate.Logistic regressions were used to investigate correlates of depression in these patients.Results:Of the 265 patients(mean age 36.9±10 years)studied,136(51.3%)were female.The prevalence of depression was 61.1%(95%CI:55.1–66.8),with a significant proportion(36.6%)having mild depression.Multivariable logistic regression analysis showed that being female(aOR=3.0,95%CI(1.7–5.5),P<0.001),having a family history of mental illness(aOR=2.5,95%CI:1.3–5.4,P>0.05),being on retreatment for TB(aOR=11.2,95%CI:5.2–31.1,P<0.001),having discontinued treatment(aOR=8.2,95%CI:1.1–23.3,P<0.05)and having a HIV/TB co-infection(aOR=2.5,95%CI:1.2–6.5,P<0.001)were factors associated with having a higher chance of being depressed.Conclusion:Our study suggests that there is a high prevalence of depression among PTB patients,with more than one in two patients affected.Multidisciplinary care for TB patients involving mental health practitioners is highly encouraged,especially for high-risk groups. | Jules Kehbila Cyril Jabea Ekabe Leopold Ndemnge Aminde Jean Jacques NNoubiap Peter Nde Fon Gottlieb Lobe Monekosso | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 4 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 5 | Impact of OSA on cardiovascular events after coronary artery bypass surgery显示文摘 | UCHOA C H DANZI-SOARES NDE J NUNES F S | 2015 | Chest2015，147，： | 1 |
| 6 | Primary ciliary dyskinesia:considerations regarding six cases of Kartagener syndrome显示文摘 | Ortega HA Vega Nde A Santos BQ | 2007 | JBras Pneumol2007，33，5： | 1 |
| 7 | Pharmacology of angiotensin Ⅱ recept-or in the kidney显示文摘 | Gasparo NDE Levens NR | 1994 | Kidney Int1994，46，： | 1 |
| 8 | Primary ciliary dyskinesia: considerations regarding six cases of Kartagener syndrome 显示文摘 | Ortega HA Vega Nde A Santos BG | 2007 | J Bras Pneumol2007，33，5： | 1 |
| 9 | Clinical, etiological and progression factors of hearing in sudden deafness显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 10 | Clinical, etiological and progression factors of hearing in sudden deafness 显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Braz J Otorhinolaryngol2005，71，5： | 1 |
| 11 | Limestone Filler Cement in Low w/c Concrete: Arational Use of Energy显示文摘 | Bonavetti V Donza H Mene'nde G | 2003 | Cement and Concrete Res2003，，33： | 1 |
| 12 | Clinical,etiological and progression factors of hearingin sudden deafness显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Rev Bras Otorrinolaringol2005，71，5： | 1 |
| 13 | Intracranial complications of otitis media:15 years of experiences in 33 patients显示文摘 | Penido Nde O Borin A Iha LC | 2005 | Otolaryngol Head Neck Surg2005，132，1： | 1 |
| 14 | Case for diagnosis 显示文摘 | Lima Lde A Haddad Nde C Lima RB | 2014 | An Bras Dermatol2014，89，3： | 1 |
| 15 | Clinical, etiological and progression factors of hearing in sudden deafness 显示文摘 | Penido Nde O Ramos HV Barros FA | 2005 | Rev Bras Otorrinolaringol2005，71，5： | 1 |
| 16 | P&thologic migration Spontaneous correction following periodont&l therapy: A case report显示文摘 | Singh J Deshp&nde R | 2002 | Quintessence Int2002，35，1： | 1 |
| 17 | Effect of N acetylcysteine on vasospasm in subarachnoid hemor rhage显示文摘 | Pereira Filho Nde A Pereira Filho Ade A Soares P | 2010 | Arq Neuroopsiquiatr2010，68，6： | 1 |
| 18 | Multiple sclerosis starting before the age of 18 years: the Brazilian experience 显示文摘 | FRAGOSO Y D FERREIRA M L MORALES NDE M | 2013 | Arq Neuropsiquiatr2013，71，10： | 1 |
| 19 | Chitosan as a growth stimulator in orchid tissue culture显示文摘 | Nde K L Nwea N Chandrkrachang S | 2006 | Plant Science2006，17，： | 1 |
| 20 | Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats显示文摘 | Ocarino Nde M Boeloni JN Jorqetti V | | 0，，06： | 1 |
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