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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | 面向6G物联网的分布式译码技术显示文摘随着5G商业化和标准化的逐步推进,对6G技术的研究也提上了日程。由于其在6G无线通信系统中的巨大应用前景,物联网(IoT)技术引起了人们广泛的兴趣。面向6G的物联网网络需要允许大量设备接入并支持海量数据传输,其鲁棒性和可扩展性至关重要。在物联网中,所述“事物”(用户)可以通过采用各种多功能无线传感器实时收集环境数据。通常来说,收集的数据将反馈到中央单元以进行进一步处理。但是这一机制依赖于中央单元的正常工作,鲁棒性较差。该文提出一种分布式译码算法,该算法通过让各用户之间互相协作,交换信息来实现在各个用户处完成译码。利用分布式译码算法,每个用户可以得到与中心化处理相似的译码性能,从而提高了网络的鲁棒性和可扩展性。同时,相比传统分布式译码算法,该算法不需要每个用户了解网络的拓扑结构,因此为面向6G的高动态物联网提供了技术支撑。 | 袁伟杰 李双洋 种若汐 白宝明 D W K NG | 2021 | 电子与信息学报2021，43，1： | 7 |
| 3 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 4 | Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives显示文摘The novel severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and an ongoing severe pandemic.Curative drugs specific for COVID-19 are currently lacking.Chloroquine phosphate and its derivative hydroxychloroquine,which have been used in the treatment and prevention of malaria and autoimmune diseases for decades,were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.Therefore,chloroquine phosphate was first used in the treatment of COVID-19 in China.Later,under a limited emergencyuse authorizati on from the FDA,hydroxychloro quine in combi nation with azithromyci n was used to treat COVID-19 patie nts in the USA,although the mechanisms of the anti-COVID-19 effects remain unclear.Preliminary outcomes from clinical trials in several countries have gen erated con troversial results.The desperatio n to control the pan demic overrode the con cerns regardi ng the serious adverse effects of chloro quine derivatives and combi nation drugs,i ncluding lethal arrhythmias and cardiomyopathy.The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease.While respiratory symptoms are the major clin ical man ifestati ons,cardiovascular abno rmalities,in eluding arrhythmias,myocarditis,heart failure,and ischemic stroke,have been reported in a significant number of COVID-19 patients.Patients with preexisting cardiovascular conditions(hypertension,arrhythmias,etc.)are at increased risk of severe COVID-19 and death.From pharmacological and cardiovascular perspectives,therefore,the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated,and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. | Xiao-lei Zhang Zhuo-ming Li Jian-tao Ye Ji ng Lu Lingyu Linda Ye Chun-xiang Zhang Pei-qing Liu Dayue D Duan | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 5 | Dynamic balanced key tree management for secure multicast communications 显示文摘 | NG W H D HOWARTH M SUN Z | 2007 | IEEE Trans on Computers2007，56，5： | 1 |
| 6 | The 5 UTR negatively regulates quantitative and spatial expression from the ABI3 promoter显示文摘 | Ng D W Chandrasekharan M B Hall T C | 2004 | Plant Molecular Biology2004，54，1： | 1 |
| 7 | Composition and accumulation of secondary carotenoids in Chlorococcum sp显示文摘 | LEE Y K NG M L PHANG S M | 1997 | J Appl Phycol1997，9，： | 1 |
| 8 | Reexamining the stages of concern questionnaire: A test of alternative models显示文摘 | Cheung D Hattie J Ng D | 2001 | Journal of Educational Research2001，94，4： | 1 |
| 9 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 10 | Review of cases reported over the past twenty -five years 显示文摘 | Miguel G madariaga NG Sandra D polymyositis - like syn- drome in hypothyroidism | 2002 | Thyroid2002，12，： | 1 |
| 11 | Board level solder joint relia- bility modeling and testing of TFBGA packages for telecom- munication applications 显示文摘 | Tee T Y Ng H S Yap D | 2003 | Microelectronics Reliability2003，43，7： | 1 |
| 12 | Modelling of temperature and forces when orthogonally machining hardened steel 显示文摘 | Ng E-G Aspinwall D K Brazil D | 1999 | International Journal of Machine Tools and Manufacture1999，39，6： | 1 |
| 13 | Synthesis of crystallization-distillation hybrid separation process显示文摘 | BERRY D A NG K M | 1997 | AIChE J1997，43，： | 1 |
| 14 | High reflectivity and broad bandwidth AlN/GaN distributed Bragg reflectors grown by molecular-beam epitaxy 显示文摘 | H M Ng T D Moustakas S N G Chu | 2000 | Applied Physics Letters2000，76，20： | 1 |
| 15 | The effect of amifostine on the in vitro cytotoxicity of chemotherapeutic agents in three epithelial ovarian carcinoma cell lines 显示文摘 | NG T Y NGAN H Y CHENG D K | 1999 | Gynecol Oncol1999，75，2： | 1 |
| 16 | Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism 显示文摘 | Chan D C Watts G F Ng T W | 2005 | Clin Chem2005，51，： | 1 |
| 17 | Inhibition of Campylobacter coli and Campylobacter jejuni by antibio- tics used in selective growth media 显示文摘 | Ng L K Stiles M E Taylor D E | 1985 | Journal of Clinical Microbiology1985，22，4： | 1 |
| 18 | Numerical simulations of LNG vapor dispersion in brayton fire training field tests with ANSYS CFX显示文摘 | Qi R F Ng D Cormier B R | 2010 | Journal of Hazardous Materials2010，183，13： | 1 |
| 19 | Latent dirichlet allocation显示文摘 | Blei D Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 20 | Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population显示文摘 | Cascella NG Kryszak D Bhatti B | 2011 | Schizophr Bull2011，37，1： | 1 |
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